Granted Patent
B2
US 9,884,832 · App. 14/363,116 · Granted Feb 6, 2018
Inhibitors targeting drug-resistant influenza A
Inventors:
William F. DeGrado (San Francisco, CA); Jizhou Wang (Eagleville, PA); Jun Wang (Philadelphia, PA); Hyunil Jo (Bryn Mawr, PA); Belgin Canturk (Burlington, NJ)
C07D271/06A61K31/137A61K31/15A61K31/155A61K31/26A61K31/27A61K31/41A61K31/417A61K31/4245A61K31/4402A61K31/505A61K31/5377A61K45/06C07C211/27C07C211/38C07C211/49C07C215/50C07C217/58C07C219/28C07C233/43C07C235/20C07C237/30C07C255/24C07C255/58C07C271/28C07C317/32C07C323/32C07D207/335C07D213/38C07D233/88C07D257/04C07D261/08A61K31/422C07C2601/02C07C2603/74C07D413/04
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Abstract
Provided are compounds according to formula (Ia) or (Ib) as described herein, that are capable of modulating the activity of influenza viruses (e.g., influenza A virus), for example, via interaction with the M2 transmembrane protein, and other similar viroporins. Also provided are methods for treating an influenza A-affected disease state or infection comprising administering a composition comprising one or more compounds according to according to formulas (Ia′) or (Ib), as described herein.
Claims (2)
1. A compound that is selected from
or a stereoisomer, isotopically substituted analogue, or pharmaceutically acceptable salt thereof.
Assignments (2)
CONFIRMATORY LICENSE
Recorded Oct 16, 2014
From: UNIVERSITY OF PENNSYLVANIA
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 034012/0333 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jun 5, 2014
From: DEGRADO, WILLIAM F.; WANG, JIZHOU; WANG, JUN; JO, HYUNIL; CANTURK, BELGIN
To: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
Reel/Frame 033039/0423 →
Continuity (3)
Provisional Application
61567328
· Dec 6, 2011
Provisional Application
61705310
· Sep 25, 2012