System and atraumatic mandrel for creating graft devices

1. A system for applying a fiber matrix onto a tubular conduit, the system comprising:

a tubular conduit comprising an inner surface and an outer surface;

a mandrel comprising an elongate shaft and a rolling membrane; and

a fiber matrix delivery assembly, wherein the fiber matrix delivery assembly is constructed and arranged to receive the mandrel and to apply a fiber matrix to the outer surface of the tubular conduit.

2. The system of claim 1 wherein the mandrel is constructed and arranged such that advancement of the elongate shaft causes the rolling membrane to engage with the tubular conduit inner surface.

3. The system of claim 1 wherein the mandrel is constructed and arranged such that advancement of the elongate shaft causes the rolling membrane to fold over onto itself.

4. The system of claim 3 wherein the elongate shaft comprises an expandable shaft and wherein the mandrel is constructed and arranged such that expansion of the elongate shaft causes the rolling membrane to engage with the tubular conduit inner surface.

5. The system of claim 1 wherein the mandrel is constructed and arranged such that retraction of the elongate shaft disengages the rolling membrane with the inner surface of the tubular conduit.

6. The system of claim 1 wherein the mandrel comprises a relatively straight mandrel.

7. The system of claim 1 wherein the mandrel comprises at least one curved portion.

8. The system of claim 1 wherein the mandrel comprises a lumen.

9. The system of claim 1 wherein the mandrel comprises a distal end and a guidewire extending from said distal end.

10. The system of claim 1 wherein the rolling membrane comprises a material selected from the group consisting of: polyester, polyamide, polyethylene terephthalate, crosslinked polyethylene, polyurethane, polyvinylchloride, polytetrafluoroethylene, nylon, polyether block amides, silicone, polyether, and any combinations thereof.

11. The system of claim 1 further comprising at least one axial stiffener positioned on and/or within the rolling membrane.

12. The system of claim 11 wherein the at least one axial stiffener is constructed and arranged to reduce a motion of the rolling membrane selected from the group consisting of: twisting; folding; collapsing; and combinations thereof.

13. The system of claim 1 further comprising a pressurization assembly comprising a pressurization area, said pressurization area constructed and arranged to provide axial support to the rolling membrane as the rolling membrane folds over onto itself.

14. The system of claim 1 wherein the rolling membrane comprises a conductive membrane.

15. The system of claim 1 wherein the rolling membrane comprises at least one porous portion.

16. The system of claim 15 , further comprising a fluid delivered to the tubular conduit via the rolling membrane and arranged to perform a function selected from the group consisting of: hydrate the tubular conduit;

deliver one or more drugs, cells or other agents to the tubular conduit; modify the tubular conduit; cool or warm the tubular conduit; and combinations thereof.

17. The system of claim 1 wherein the elongate shaft comprises an expandable shaft.

18. The system of claim 1 wherein the elongate shaft comprises at least one tapered end.

19. The system of claim 1 wherein the fiber matrix delivery assembly comprises a device selected from the group consisting of: electrospinning unit; misting assembly; sipping assembly; sprayer; braiding device; micropatterning device; injection device; and combinations thereof.

20. The system of claim 1 wherein the tubular conduit comprises a living tissue selected from the group consisting of: vein; saphenous vein; artery; lymphatic duct; vas deferens; tear duct; intestine; esophagus; ureter; urethra; trachea; bronchi; duct tissue; Eustachian tube; fallopian tube; and combinations thereof.