Biodegradable vascular grafts
View Patent ↗Disclosed herein are biodegradable scaffolds for in situ tissue engineering. In some examples, biodegradable vascular grafts and methods of fabricating and uses of such are disclosed. In some examples, a vascular graft includes a biodegradable scaffold including a biodegradable polyester tubular core, a biodegradable polyester electrospun outer sheath surrounding the biodegradable polyester tubular core and/or a thromboresistant agent, such as heparin, coating the biodegradable scaffold. The disclosed vascular grafts can be used for forming a blood vessel of less than 6 mm, including, but not limited to a coronary or peripheral arterial.
1. A vascular graft, comprising:
a biodegradable scaffold comprising a biodegradable polyester tubular core of poly(glycerol sebacate) (PGS) having small pores of about 1 μm to about 500 μm and comprising an inner lumen surface and an outer surface; and
a biodegradable polyester electrospun outer sheath consisting essentially of poly(caprolactone) (PCL) having a thickness between 5 μm and 30 μm and surrounding the outer surface of the biodegradable polyester tubular core, thereby forming a vascular graft; and
wherein the vascular graft is cell-free.
2. The vascular graft of claim 1 , further comprising a thromboresistant agent coating the biodegradable scaffold.
3. The vascular graft of claim 2 , wherein the thromboresistant agent comprises heparin.
4. The vascular graft of claim 2 , wherein the thromboresistant agent coats the inner lumen surface of the biodegradable polyester tubular core.
5. The vascular graft of claim 1 , wherein at least 75% of the pores are interconnected.
6. The vascular graft of claim 1 , wherein at least 95% of the pores are interconnected.
7. The vascular graft of claim 1 , wherein at least 99% of the pores are interconnected.
8. The vascular graft of claim 1 , wherein the vascular graft has an inner diameter of between 700 μm to 5000 μm.
9. The vascular graft of claim 1 , wherein the vascular graft has a wall thickness between 100 μm and 500 μm, such as about 290 μm.
10. The vascular graft of claim 1 , wherein at least 95% of the vascular graft degrades within 90 days of implantation.
11. The vascular graft of claim 1 , wherein the vascular graft is used for forming a blood vessel with a diameter of less than 6 mm.
12. The vascular graft of claim 1 , wherein the vascular graft is used as a coronary or a peripheral arterial graft.
13. The vascular graft of claim 1 , wherein the biodegradable scaffold comprises a wall thickness of from 100 μM to 500 μM.
14. The vascular graft of claim 1 , wherein at least 90% of the vascular graft degrades within 12 weeks of implantation in a subject.
15. The vascular graft of claim 1 , wherein the vascular graft is used for forming a blood vessel with a diameter of less than 4 mm.