Biocompatible method of functionalizing substrates with inert surfaces
View Patent ↗Method of functionalizing microspheres comprising immersing the microspheres in an aqueous dispersion of a construct of the structure F-S-L; and then washing the microspheres with an aqueous vehicle to provide the functionalized microspheres. The construct is of the structure: where F is a functional moiety, M is a monovalent cation, R 1 and R 2 are independently a C 14-20 acyl, alkyl or alkenyl group, and S is a spacer selected to provide a construct that is dispersible in water.
1. A method of functionalising microspheres comprising the steps of:
immersing the microspheres in an aqueous dispersion of a construct of the structure F-S-L; and then
washing the microspheres with an aqueous vehicle to provide the functionalised microspheres,
where the construct is a construct of the structure:
where F is a functional moiety, M is a monovalent cation, R 1 and R 2 are independently a C 14-20 acyl, alkyl or alkenyl group, and S is a spacer selected to provide a construct that is dispersible in water; and where the microsphere is a polycarbonate microsphere.
2. The method of claim 1 where the construct is a construct of the structure:
where R 3 and R 4 are independently a C 13-19 alkyl or alkenyl group.
3. The method of claim 2 where R 3 and R 4 are independently a C 15-17 alkyl or alkenyl group.
4. The method of claim 3 where the construct is a construct of the structure: