Sample holder for electron microscopy for low-current, low-noise analysis
A novel specimen holder for insertion in electron microscopes, wherein the novel specimen holder is designed to minimize electrical noise so that signal integrity can be maintained during in situ electron microscopy.
1. An electron microscope specimen holder comprising a specimen tip, at least one electrical noise minimizer, a holder rod, a holder handle, at least one shielded cable running from the specimen tip down the length of the holder rod to the holder handle, wherein the at least one electrical noise minimizer comprises one of the following combinations,
(a) a low-noise power supply and at least one triaxial/coaxial connector;
(b) an amplifier/preamplifier in the holder handle;
(c) a low-noise power supply, at least one triaxial/coaxial connector, and an amplifier/preamplifier in the holder handle;
(d) an A/D and/or D/A signal converter in the holder handle;
(e) a low-noise power supply, at least one triaxial/coaxial connector, and an A/D and/or D/A signal converter in the holder handle;
(f) an amplifier/preamplifier and an A/D and/or D/A signal converter in the holder handle; or
(g) a low-noise power supply, at least one triaxial/coaxial connector, and an amplifier/preamplifier and an A/D and/or D/A signal converter in the holder handle.
2. The electron microscope specimen holder of claim 1 , comprising combination (a).
3. The electron microscope specimen holder of claim 1 , wherein the at least one shielded cable comprises internal wiring extending from an external connector to a region in proximity of the specimen tip.
4. The electron microscope specimen holder of claim 2 , further comprising the amplifier/preamplifier, the A/D and/or D/A signal converter, or both the amplifier/preamplifier and the A/D and/or D/A signal converter.
5. The electron microscope specimen holder of claim 1 , wherein a specimen device can interface with the specimen tip.
6. A method of minimizing electrical noise in an electron microscopy specimen holder, said method comprising incorporating at least one electrical noise minimizer in said electron microscopy specimen holder, wherein said holder comprises a specimen tip, a holder rod, a holder handle, at least one shielded cable running from the specimen tip down the length of the holder rod to the holder handle, wherein the at least one electrical noise minimizer comprises one of the following combinations,
(a) a low-noise power supply and at least one triaxial/coaxial connector;
(b) an amplifier/preamplifier in the holder handle;
(c) a low-noise power supply, at least one triaxial/coaxial connector, and an amplifier/preamplifier in the holder handle;
(d) an A/D and/or D/A signal converter in the holder handle;
(e) a low-noise power supply, at least one triaxial/coaxial connector, and an A/D and/or D/A signal converter in the holder handle;
(f) an amplifier/preamplifier and an A/D and/or D/A signal converter in the holder handle; or
(g) a low-noise power supply, at least one triaxial/coaxial connector, and an amplifier/preamplifier and an A/D and/or D/A signal converter in the holder handle.
7. The electron microscope specimen holder of claim 1 , wherein a membrane-based MEMS device is interfaced with the specimen tip.
8. The method of claim 6 , wherein the holder further comprises a membrane-based MEMS device interfaced with the specimen tip.