IP Library Granted Patent US 10,214,476
Granted Patent B2
US 10,214,476 · App. 14/369,674 · Granted Feb 26, 2019

Pain relief compounds

Inventors: Sylvie Ducki (Aubiere, FR); Khalil Bennis (Clermont Ferrand, FR); Alain Eschalier (Chamalieres, FR); Jérôme Busserolles (Saulzet, FR); Florian Lesage (Valbonne, FR); Nuno Rodrigues (Aubiere, FR); Delphine Vivier (Lempdes, FR)
Assignees: ECOLE NATIONALE SUPERIEURE DE CHIMIE DE CLERMONT FERRAND; UNIVERSITÉ CLERMONT AUVERGNE
C07C57/60C07C229/34C07C255/41C07D209/18C07D209/42C07D307/54C07F9/09C07F9/12C07C2601/14
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Quick Facts
Patent No.
US 10,214,476
App. No.
14/369,674
Granted
Feb 26, 2019
Kind
B2
Abstract

The present invention relates to the use of compounds for the treatment or prevention of pain in mammals, in particularly in human beings, and also to a process for preparing these compounds.

Claims (30)

1. A compound of formula (A1):

wherein:

R represents:

Q represents —CN;

X represents O, or —NH;

T represents:

a hydrogen atom;

a phenyl group;

a group

a cyclohexyl group;

Q 2 represents O, or NH;

or a pharmaceutically acceptable salt of said compound.

2. The compound according to claim 1 , wherein:

Q represents —CN;

Q 2 represents O, or NH

X represents O or NH

T represents:

a hydrogen atom;

a phenyl group;

a group

3. The compound according to claim 1 , wherein:

Q 2 represents O;

X represents O;

T represents H.

4. The compound according to claim 1 of formula (1b):

wherein Q 2 , Q, X and T are as defined in claim 1 .

5. A method for treatment of pain comprising administering to a patient, a composition comprising a compound according to claim 1 .

6. A method for treatment of pain comprising administering to a patient, a composition comprising a compound according to claim 2 .

7. A method for treatment of pain comprising administering to a patient, a composition comprising a compound according to claim 1 .

8. A method for treatment of pain comprising administering to a patient, a composition comprising a compound according to claim 3 .

Assignments (2)
MERGER AND CHANGE OF NAME Recorded Feb 9, 2018
From: UNIVERSITE D'AUVERGNE CLERMONT I; UNIVERSITÉ CLERMONT AUVERGNE
To: UNIVERSITÉ CLERMONT AUVERGNE
Reel/Frame 045301/0702 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 30, 2014
From: DUCKI, SYLVIE; BENNIS, KHALIL; ESCHALIER, ALAIN; BUSSEROLLES, JEROME; LESAGE, FLORIAN; RODRIGUES, NUNO; VIVIER, DELPHINE
To: ECOLE NATIONALE SUPERIEURE DE CHIMIE DE CLERMONT FERRAND; UNIVERSITE D'AUVERGNE CLERMONT I
Reel/Frame 033214/0750 →
Priority Claims (1)
FR 11 62564 · Dec 30, 2011 · national
Continuity (2)
Related Publication 20150038466A1 · Feb 5, 2015
Related Publication 20150274633A2 · Oct 1, 2015