Cell adhesion inhibitor
Provided is a cell adhesion inhibitor which exhibits low cytotoxicity and an excellent cell adhesion prevention effect; a tool and an apparatus each having a surface modified through application of the cell adhesion inhibitor thereto; a method for producing each of the surface-modified tool and apparatus; a biomedical structure and a production method therefor; and a microchannel device and a production method therefor. The invention provides a cell adhesion inhibitor comprising, as an active ingredient, a polymer comprising a repeating unit having a sulfinyl group in a side chain thereof.
1. A method for preventing a cell adhesion, the method comprising a step of using a polymer comprising a repeating unit having a sulfinyl group and a hydroxy group in a side chain thereof.
2. The method for preventing a cell adhesion according to claim 1 , wherein an object for preventing the cell adhesion is a substrate, a tool or an apparatus.
3. The method for preventing a cell adhesion according to claim 1 , wherein at least a portion of the substrate, the tool or the apparatus is coated with the polymer.
4. The method for preventing a cell adhesion according to claim 1 , wherein the repeating unit having a sulfinyl group in a side chain thereof is hydrophilic.
5. The method for preventing a cell adhesion according to claim 1 , wherein the repeating unit having a sulfinyl group in a side chain thereof is represented by the following formula (2):
wherein R 1 represents a hydrogen atom or a methyl group; R 2 represents —O—, *—(C═O)—O—, *—(C═O)—NR 5 —, *—NR 5 —(C═O)— (R 5 represents a hydrogen atom or a C1 to C10 organic group; and * denotes the position of bonding to the carbon atom to which R 1 is bonded in formula (2)), or a phenylene group; R 3 represents a direct bond or a C1 to C24 divalent organic group; and R 4 represents a C1 to C10 organic group.
6. The method for preventing a cell adhesion according to claim 1 , wherein the polymer further comprises a hydrophobic repeating unit.
7. The method for preventing a cell adhesion according to claim 6 , wherein the hydrophobic repeating unit is derived from at least one monomer selected from the group consisting of styrenes, (meth)acrylates, and (meth)acrylamides.
8. The method for preventing a cell adhesion according to claim 1 , wherein the repeating unit having a sulfinyl group in a side chain thereof is nonionic.
9. The method for preventing a cell adhesion according to claim 1 , wherein the polymer is water-soluble.
10. The method for preventing a cell adhesion according to claim 1 , wherein the polymer has an HLB of 10 to 22.