IP Library Granted Patent US 10,386,367
Granted Patent B2
US 10,386,367 · App. 14/370,217 · Granted Aug 20, 2019

Method for producing an examination reagent and kit for analysing a T-cell frequency

Inventors: Sebastian Hartmut Springer (Bremen, DE); Sunil Kumar Saini (Kerala, IN)
Assignee: JACOBS UNIVERSITY BREMEN GGMBH
G01N33/566C07K14/70539G01N33/56977G01N2333/70539
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Quick Facts
Patent No.
US 10,386,367
App. No.
14/370,217
Granted
Aug 20, 2019
Kind
B2
Abstract

A method for producing an examination reagent includes adding a helper ligand to an unfolded receptor protein in an initial solution so as to provide a pre-solution of the examination reagent with a folded receptor protein. The folded receptor protein comprises a bonded helper ligand which can be exchanged with an examination peptide.

Claims (2)

1. A murine MHC class I protein H-2K b in complex with human beta-2-microglobulin (the H-2K b /β 2 m complex), the H-2K b /β 2 m complex comprising:

a glycyl-leucine (GL) dipeptide bound thereto in the dipeptide peptide binding groove of the H-2K b /β 2 m complex.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 2, 2014
From: SPRINGER, SEBASTIAN HARTMUT, MR.; SAINI, SUNIL KUMAR, MR.
To: JACOBS UNIVERSITY BREMEN GGMBH
Reel/Frame 033227/0054 →
Priority Claims (2)
DE 20 2012 100 019 U · Jan 4, 2012 · national
DE 10 2012 101 028 · Feb 8, 2012 · national
Continuity (1)
Related Publication 20140370524A1 · Dec 18, 2014