IP Library › Granted Patent US 9,611,305
Granted Patent B2
US 9,611,305 · App. 14/370,554 · Granted Apr 4, 2017

Treating cardiovascular or renal diseases

Inventors: Yasuhiro Ikeda (Rochester, MN); Stephen James Russell (Rochester, MN); Alessandro Cataliotti (Rochester, MN); John C. Burnett, Jr. (Rochester, MN); Jason M. Tonne (Rochester, MN)
Assignee: Mayo Foundation for Medical Education and Research
C07K14/4705C07K14/58C12N7/00C12N15/86C07K2319/02C12N2750/14143C12N2750/14171
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Quick Facts
Patent No.
US 9,611,305
App. No.
14/370,554
Granted
Apr 4, 2017
Kind
B2
Abstract

This document provides methods and materials for treating cardiovascular and/or renal diseases. For example, AAV9 vectors designed to express natriuretic polypeptides, nucleic acid molecules encoding natriuretic polypeptides, methods for making AAV9 vectors, and methods for using such vectors or molecules to treat cardiovascular and/or renal diseases are provided.

Claims (4)

1. A method for improving cardiac function in a mammal with polycystic kidney disease, wherein said method comprises administering an AAV9 vector to said mammal with polycystic kidney disease,

wherein said AAV9 vector comprises a nucleic acid sequence encoding a natriuretic polypeptide, and

wherein cardiac function is improved at least two months following said administration when said AAV9 vector is administered to said mammal with polycystic kidney disease.

2. The method of claim 1 , wherein said mammal is a human.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 29, 2015
From: IKEDA, YASUHIRO; RUSSELL, STEPHEN JAMES; CATALIOTTI, ALESSANDRO; BURNETT, JOHN C., JR.; TONNE, JASON M..
To: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
Reel/Frame 035738/0702 →
CONFIRMATORY LICENSE Recorded Dec 22, 2014
From: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 034692/0875 →
Continuity (2)
Provisional Application 61584006 · Jan 6, 2012
Related Publication 20150005371A1 · Jan 1, 2015