Substituted pyrano and furanoquinolines, their preparation and use as medicaments

1. A compound of the following general formula:

wherein

R 1 is a saturated C 4-9 cycloalkyl optionally at least monosubstituted, optionally containing one heteroatom as a ring member selected from N, O or S, which may be condensed with an optionally at least monosubstituted mono polycyclic ring system;

R 2 is selected from the group consisting of hydrogen; a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted, aliphatic radical C 1-10 or —CH 2 R 5 ;

R 3 and R 4 are independently selected from the group consisting of hydrogen; —NO 2 ; —CF 3 ; —OH; —SH; —NR 5 R 6 ; —CN; a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted, aliphatic radical C 1-10 ; a saturated or unsaturated C 3-9 cycloalkyl optionally at least rnoriosubstituted, optionally at least containing one heteroatom as a ring member selected from N, O or S which may be condensed with an optionally at least monosubstituted mono or polycyclic ring system; a substituted or unsubstituted aryl; —NHC(O)NHR 7 ; —NHC(S)NHR 7 ; —C(O)OR 8 ; —OR 9 ; —NR 10 C(O)R 11 ; —SR 12 ; —C(O)NR 13 R 14 ; —SO 2 NR 15 R 16 , or halogen;

R 5 to R 12 are independently selected from hydrogen; a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted, aliphatic radical C 1-10 ; substituted or unsubstituted aryl; substituted or unsubstituted C 3-9 cycloalkyl optionally at least containing one heteroatom as a ring member selected from N, O or S which may be condensed with an optionally at least monosubstituted mono or polycyclic ring system; or substituted or unsubstituted heteroaryl which may be condensed with an optionally at least monosubstituted mono or polycyclic ring system;

R 13 to R 16 are independently selected from hydrogen; a branched or unbranched, saturated or unsaturated, optionally at least mono-substituted, aliphatic radical C 1-10 ; substituted or unsubstituted aryl; substituted or unsubstituted C 3-9 cycloalkyl optionally at least containing one heteroatom as a ring member selected from N, O or S which may be condensed with an optionally at least monosubstituted mono or polycyclic ring system; substituted or unsubstituted heteroaryl which may be condensed with an optionally at least monosubstituted mono or polycyclic ring system;

or R 13 to R 16 together with a bridging nitrogen form a C 3-9 cycloalkyl optionally containing at least one additional heteroatom as a ring member selected from N, O or S;

n is 0 or 1;

with the proviso that at least one of R 3 or R 4 is always different from hydrogen and with the proviso that when R 1 is cyclohexyl, unsubstituted tetrahydrofurane or substituted pyrrolidine, if R 3 or R 4 are in position 8 when n=0 or in position 9 when n=1, they are not tert-butyl, or a pharmaceutically acceptable salt or stereoisomer thereof.

2. A compound according to claim 1 , wherein R 1 is adamantly or the following group:

where X represents a —CH 2 —, —O—, —NR 17 —or —S— and m=0 or 1 being R 17 a C 1-6 alkyl, a benzyl or a hydrogen.

3. A compound according to claim 1 , wherein R 2 is hydrogen or C 1-5 alkyl.

4. A compound according to claim 1 , wherein R 3 and R 4 are independently selected from the group consisting of hydrogen; halogen; —NO 2 ; —CF 3 ;—OH; —SH; —NR 5 R 6 ; —CN; a substituted or unsubstituted, branched or unbranched C 1-6 alkyl; —NHC(O)NHR 7 ; —C(O)OR 8 ; —OR 9 ; —SR 12 ; —SO 2 NR 15 R 16 or a group selected from:

wherein R independently represents e hydrogen; substituted or unsubstituted, branched or unbranched C 1-6 alkyl, an OH or a halogen and wherein m=0 or 1 and p=3 or 4.

5. A compound according to claim 1 , wherein R 1 is adamantlyl or the following group:

wherein X represents a —CH 2 —, —O—, —NR 17 — or —S— and m=0 or 1 being R 17 a C 1-6 alkyl or a hydrogen;

R 2 is hydrogen or C 1-6 alkyl;

R 3 and R 4 are independently selected from the group consisting of hydrogen; halogen; —NO 2 ; —CF 3 ; —OH; —SH; —NR 5 R 8 ; —CN; a substituted or unsubstituted, branched or unbranched C 1-6 alkyl; —NHC(O)NHR 7 ; —C(O)O R 8 ; —OR 9 ; —SR 12 ; —SO 2 NR 15 R 16 or a group selected from:

wherein R 5 , R 6 , R 7 , R 8 , R 11 , R 14 , R 15 and R 16 ; are as defined in claim 1 and R independently represents a hydrogen; substituted or unsubstituted, branched or unbranched C 1-6 alkyl; an —OH; or a halogen and wherein m=0 or 1 and p=3 or 4.

6. A compound according, to claim 1 , in the trans-isomer form:

7. A compound according to claim 1 , in the cis-isomer form:

8. A compound according to claim 1 , selected from the group consisting of:

(4aSR*, 5RS*,10bSR*)-9-(3-chlorophenoxy)-5-cyclohexyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline hydrochloride;

(4aSR*,5SR*,10bSR*)-9-(3-chlorophenoxy)-5-cyclohexyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline hydrochloride;

1-(3-chloro-2-methylpheny)-3((4aSR*,5SR*, 10bSR*)-5-cyclohexyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-9-yl)urea hydrochloride;

N-((4aSR*,5SR*,10bSR*)-5-cyclohexyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-9-yl)pentanamide hydrochloride;

(4aSR*,5SR*,10bSR*)-5-cyclohexyl-N-cyclopropyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline-9-carboxamide hydrochloride;

(4aSR*,5RS*,10bSR*)-5-(1-benzylpiperidin-4-yl)-9-(isopentyloxy)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline hydrochloride;

(4aSR*,5RS*,10bSR*)-5-cycohexyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-10-amine;

(4aSR*,5RS*,10bSR*)-5-cyclohexyl-9-(trifluoromethoxy)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline;

(4aSR*,5SR*,10bSR*)-5-cyclohexyl-8-ethyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline;

(4aSR*,5SR*,10bSR*)-ethyl 5-cyclohexyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline-9-carboxylate hydrochloride;

(4aSR*,5RS*,10bSR*)-5-cyclohexyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-9ol;

(4aSR*,5RS*,10bSR*)-5-cyclohexyl-10-nitro-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline;

(4aSR*,5RS*,10bSR*)-9-tert-butyl-5-cyclohexyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline;

(4aSR*,5RS*,10bSR*)-5-cyclohexyl-9-methoxy-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline;

(4aSR*,5RS*,10bSR*)-9-butoxy-5-cyclohexyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline hydrochloride;

(4aSR*,5SR*,10bSR*)-9-butoxy-5-cyclohexyl 3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline hydrochloride;

(4aSR*,5RS*,10bSR*)-5-cyclopentyl-9-(trifluoromethoxy)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline hydrochloride;

(4aSR*,5RS*,10bSR*)-5-cyclohexyl-9-(trifluoromethylthio)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline hydrochloride;

(4aSR*,5RS*,10bSR*)-5-cyclohexyl-9-methyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline hydrochloride;

(4aSR*,5RS*,10bSR*)-5-cyclohexyl-9-fluoro-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline hydrochloride;

(4aSR*,5RS*,10bSR*)-5-cyclohexyl-9-isopropyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline hydrochloride;

(4aSR*,5RS*,10bSR*)-5-cyclohexyl-7-(trifluoromethoxy)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline hydrochloride;

(4aSR*,5RS*,10bSR*)-9-butyl-5-cyclohexyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline hydrochloride:

(4aSR*,5RS*,10bSR*)-5,9-dicyclohexyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline hydrochloride;

(4aSR*,5RS*,10bSR*)-5-cyclohexyl-9-phenoxy-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline hydrochloride;

(4aSR*,5RS*,10bSR*)-5-cyclohexyl-9-(isopentyloxy)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline hydrochloride;

(4aSR*,5SR*,10bSR*)-5-cyclohexyl-9-(isopentyloxy)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline hydrochloride;

(3aSR*,4RS*,9bSR*)-8-butoxy-4-cyclohexyl-2,3,3a,4,5,9b-hexahydrofuro[3,2-c]quinoline hydrochloride;

(4aSR*,5RS*,10bSR*)-5-cyclohexyl-9-propoxy-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline hydrochloride;

(3aSR*,4RS*,9bSR*)-4-cyclohexyl-8-propoxy-2,3,3a,4,5,9b-hexahydrofuro[3,2-c]quinoline hydrochloride;

(3aSR*,4RS*,9bSR*)-4-cyclohexyl-8-(isopentyloxy)-2,3,3a,4,5,9b-hexahydrofuro[3,2-c]quinoline hydrochloride;

(3aSR*,4RS*,9bSR*)-propyl 4-cyclohexyl-2,3,3a,4,5,9b-hexahydrofuro[3,2-c]quinoline-8-carboxylate hydrochloride;

(3aSR*,4SR*,9bSR*)-propyl 4-cyclohexyl-2,3,3a,4,5,9b-hexahydrofuro[3,2-c]quinoline-8-carboxylate hydrochloride;

(4aSR*,5RS*,10bSR*)-5-cyclohexyl-9-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline hydrochloride;

(3aSR*,4RS*,9bSR*)-4-cyclohexyl-8-(trifluoromethoxy)-2,3,3a,4,5,9b-hexahydrofuro[3,2-c]quinoline hydrochloride;

N-((4aSR*,5RS*,10bSR*)-5-cyclohexyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-9-yl)acetamide hydrochloride;

N-((3aSR*,4RS*,9bSR*)-4-cyclohexyl-2,3,3a,4,5,9b-hexahydrofuro[3,2-c]quinolin-8-yl)acetemide hydrochloride;

(4aSR*,5RS*,10bSR*)-propyl 5-cyclohexyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline-9-carboxylate hydrochloride;

(3aSR*,4RS*,9bSR*)-8-butoxy-4-cyclohexyl-6-fluoro-2,3,3a,4,5,9b-hexahydrofuro[3,2-c]quinoline hydrochloride;

(3aSR*,4RS*,9bSR*)-4-cyclohexyl-8-(2-morpholinoethoxy)-2,3,3a,4,5,9b-hexahydrofuro[3,2-c]quinoline hydrochloride;

(3aSR*,4RS*,9bSR*)-8-butoxy-4-cyclohexyl-7-fluoro-2,3,3a,4,5,9b-hexahydrofuro[3,2-c]quinoline hydrochloride;

(3aSR*,4RS*,9bSR*)-4-cyclohexyl-8-phenyl-2,3,3a,4,5,9b-hexahydrofuro[3,2-c]quinoline hydrochloride;

(4aSR*,4RS*,10bSR*)-9-butoxy-5-cyclohexyl-8-fluoro-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline hydrochloride;

(3aSR*,4RS*,9bSR*)-4-cyclohexyl-8-nitro-2,3,3a,4,5,9b-hexahydrofuro[3,2-c]quinoline hydrochloride;

(4aSR*,5RS*,10-bSR*)-5-cyclohexyl-9-iodo-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline hydrochloride;

(4aSR*,5RS*,10bSR*)-ethyl 5-cyclohexyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline-8-carboxylate hydrochloride;

(4aSR*,5RS*,10bSR*)-ethyl 5-cyclohexyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline-10-carboxylate hydrochloride;

(4aSR*,5RS*,10bSR*)-9-butoxy-5-(piperidin-4-yl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline;

N-((4aSR*,5RS*,10bSR*)-5-cyclohexyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-9-yl)benzamide hydrochloride;

(3aSR*,4RS*,9bSR*)-4-cyclohexyl-8-phenoxy-2,3,3a,4,5,9b-hexahydrofuro[3,2-c]quinoline hydrochloride;

(4aSR*,5RS*,10bSR*)-5-cyclohexyl-9-ethyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline hydrochloride;

(4aSR*,5RS*,10bSR*)-9-phenoxy-5-(tetrahydro-2H-pyran-4-yl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline hydrochloride;

(4aSR*,5RS*,10bSR*)-methyl 5-cyclohexyl-3,4,4a,5,6,10b-hexahydro-2H-pyran[3,2-c]quinoline-9-carboxylate hydrochloride;

(4aSR*,5RS*,10bSR*)-9-(4-chlorophenoxy)-5-cyclohexyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline hydrochloride;

(4aSR*,5RS*,10bSR*)-5-cyclopentyl-9-phenoxy-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline hydrochloride;

(4aSR*,5RS*,10bSR*)-5-cyclohexyl-9-p-tolyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline hydrochloride;

4-((4aSR*,5RS*,10bSR*)-5-cyclohexyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-9-yl)phenol hydrochloride;

(4aSR*,5RS*,10bSR*)-5-cyclohexyl-9-pentyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline;

(4aSR*,5RS*,10bSR*)-5-cyclohexyl-9-pentyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline hydrochloride;

(4aSR*,5SR*,10bSR*)-5-cyclohexyl-9-pentyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline hydrochloride;

(4aSR*,5RS*,10bSR*)-5-cyclohexyl-9-(piperidin-1-ylsulfonyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline hydrochloride;

(4aSR*,5RS*,10bSR*)-9-pentyl-5-(tetrahydro-2H-pyran-4-yl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline hydrochloride;

(4aSR*,5RS*,10bSR*)-5-cyclohexyl-9-morpholino-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline hydrochloride;

(4aSR*,5RS*,10bSR*)-5-adamantyl-9-phenoxy-3,4,4a,5,6,10b-hexehydro-2H-pyrano[3,2-c]quinoline hydrochloride;

(4aSR*5RS*,10bSR*)-9-(2-chlorophenoxy)-5-cyclohexyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline hydrochloride;

(4aSR*,5RS*,10bSR*)-5-cyclohexyl-9-(2-morpholinoethoxy)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline;

(4aSR*,5RS*,10bSR*)-propyl 5-adamantyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline-9-carboxylate hydrochloride;

(4aSR*,5RS*,10bSR*)-methyl 5-cyclohexyl-7-methyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline-8-carboxylate hydrochloride;

(4aSR*,5RS*,10bSR*)-ethyl 5-cyclohexyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline-7-carboxylate hydrochloride;

(4aSR*,5RS*,10bSR*)-9-phenoxy-5-(tetrahydro-2H-thiopyran-4-yl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline hydrochloride;

(4aSR*,5RS*,10bSR*)-methyl 5-cyclopentyl-7-methyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline-8-carboxylate hydrochloride;

(4aSR*,5RS*,10bSR*)-ethyl 5-cyclopentyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline-8-carboxylate hydrochloride;

(4aSR*,5RS*,10bSR*)-ethyl 5-cyclopentyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline-10-carboxylate hydrochloride;

(3aSR*,4RS*,9bSR*)-ethyl 4-cyclopentyl-2,3,3a,4,5,9b-hexahydrofuro[3,2-c]quinoine-7-carboxylate hydrochloride;

(3aSR*,4RS*,9bSR*)-ethyl 4-cyclopentyl-2,3,3a,4,5,9b-hexahydrofuro[3,2-c]quinoline-9-carboxylate hydrochloride;

1-((4aSR*,5RS*,10bSR*)-5-cyclohexyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-9-yl)-3-cyclopropylthiourea hydrochloride;

(4aSR*,5RS*,10bSR*)-5-cyclopentyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline-9-carbonitrile hydrochloride;

(4aSR*,5RS*,10bSR*)-5-cyclopentyl-9-(piperidin-1-ylsulfonyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline hydrochloride;

(3aSR*,4RS*,9bSR*)-4-cyclopentyl-8-(piperidin-1-ylsulfonyl)-2,3,3a,4,5,9b-hexahydrofuro[3,2-c]quinoline;

(4aSR*,5RS*,10bSR*)-5-cyclopentyl-N,N-dimethyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline-9-sulfonamide hydrochloride;

(4aSR*5RS*,10bSR*)-5-cyclopentyl-N,N-diethyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline-9-sulfonamide hydrochloride;

(3aSR*,4RS*,9bSR*)-4-cyclohexyl-2,3,3a,4,5,9b-hexahydrofuro[3,2-c]quinolin-8-ol hydrochloride;

(3aSR*,4RS*,9bSR*)-4-cyclohexyl-8-pentyl-2,3,3a,4,5,9b-hexahydrofuro[3,2-c]quinoline hydrochloride;

(3aSR*,4RS*,9bSR*)-8-pentyl-4-(tetrahydro-2H-pyran-4-yl)-2,3,3a,4,5,9b-hexahydrofuro[3,2-c]quinoline hydrochloride;

(3aSR*,4RS*,9bSR*)-8-(4-chlorophenoxy)-4-cyclohexyl-2,3,3a,4,5,9b-hexahydrofuro[3,2-c]quinoline;

(3aSR*,4RS*,9bSR*)-8-(4-chlorophenoxy)-4-cyclohexyl-2,3,3a4,5,9b-hexahydrofuro[3,2-c]quinoline hydrochloride;

(3aSR*,4RS*,9bSR*)-8-(benzyloxy)-4-cyclohexyl-2,3,3a,4,5,9b-hexahydrofuro[3,2-c]quinoline hydrochloride;

(4aSR*,5RS*,10bSR*)-5-cyclohexyl-N-propyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline-9-sulfonamide;

(4aSR*,5RS*,10bSR*)-5-cyclohexyl-9-(4-fluorobenzyloxy)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline hydrochloride;

(3aSR*,4RS*,9bSR*)-4-cyclohexyl-8-(4-fluorobenzyloxy)-2,3,3a,4,5,9b-hexahydrofuro[3,2-c]quinoline hydrochloride;

(3aSR*,4RS*,9bSR*)-4-cyclohexyl-8-(3,4-dichlorophenoxy)-2,3,3a,4,5,9b-hexahydrofuro[3,2-c]quinoline hydrochloride;

(4aSR*,5RS*,10bSR*)-5-cyclohexyl-9-(3,4-dichlorophenoxy)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline hydrochloride;

(3aSR*,4RS*,9bSR*)-ethyl 4-cyclohexyl-2,3,3a,4,5,9b-hexahydrofuro[3,2-c]quinoline-8-carboxylate hydrochloride;

(3aSR*,4RS*,9bSR*)-8-pentyl-4-(tetrahydro-2H-thiopyran-4-yl)-2,3,3a,4,5,9b-hexahydrofuro[3,2-c]quinoline hydrochloride;

(3aSR*,4RS*,9bSR*)-8-(2-chlorophenoxy)-4-cyclohexyl-2,3,3a,4,5,9b-hexahydrofuro[3,2-c]quinoline hydrochloride;

(3aSR*,4RS*,9bSR*)-4-cyclohexyl-N-phenyl-2,3,3a,4,5,9b-hexahydrofuro[3,2-c]quinolin-8-amine hydrochloride;

(4aSR*,5RS*,10bSR*)-5-cyclohexyl-9-ethoxy-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline hydrochloride;

N-((3aSR*,4RS*,9bSR*)-4-cyclohexyl-2,3,3a,4,5,9b-hexahydrofuro[3,2-c]quinolin-8-yl)benzamide hydrochloride;

(4aSR*,5RS*,10bSR*)-9-(isopentyloxy)-5-(piperidin-4-yl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline hydrochloride;

(4aSR*,5RS*,10bSR*)-9-(isopentyloxy)-5-(tetrahydro-2H-pyran-4-yl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline hydrochloride;

(3aSR*,4RS*,9bSR*)-4-cyclohexyl-6-(isopentyloxy)-2,3,3a,4,5,9b-hexahydrofuro[3,2-c]quinoline;

(3aSR*,4RS*,9bSR*)-4-cyclohexyl-8-morpholino-2,3,3a,4,5,9b-hexahydrofuro[3,2-c]quinoline hydrochloride;

(4aSR*,5RS*,10bSR*)-9-methoxy-5-(piperidin-4-yl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline hydrochloride;

(4aSR*,5RS*,10bSR*)-5-cyclopentyl-9-(isopentyloxy)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline hydrochloride;

3-((3aSR*,4RS*,9bSR*)-4-cyclohexyl-2,3,3a,4,5,9b-hexahydrofuro[3,2-c]quinolin-8-yloxy)propan-1-amine hydrochloride;

1-((4aSR*,5RS*,10bSR*)-5-cyclohexyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-9-yl)-3-(2,3-dichlorophenyl)urea hydrochloride;

(4aSR*,5RS*,10bSR*)-9-methoxy-5-(1-phenethylpiperidin-4-yl)-3,4,4a5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline hydrochloride;

(4aSR*,5RS*,10bSR*)-5-(1-(4-chlorobenzyl)piperidin-4-yl)-9-methoxy-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline hydrochloride;

(4aSR*,5RS*,10bSR*)-5-(1-ethylpiperidin-4-yl)-9-(isopentyloxy)-3,4,4a5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline hydrochloride;

4-((4aSR*,5RS*,10bSR*)-5-cyclohexyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-9-yloxy)butan-1-amine hydrochloride;

3((4aSR*,5RS*,10bSR*)-5-cyclohexyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-9-yloxy)propan-1-amine hydrochloride;

(4aSR*,5RS*,10bSR*)-5-cyclohexyl-9-(methylthio)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline hydrochloride;

(4aS,5R,10bS)-9-(isopentyloxy)-5-(tetrahydro-2H-pyran-4-yl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline hydrochloride;

(4SR*,5RS*,10bSR*)-5-cyclohexyl-9-(isopentyloxy)-6-methyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline.

9. A process for the preparation of a compound of general formula (Ia) and/or (Ib):

where R 1 , R 3 , R 4 and n have the same meaning as in claim 1 , the process comprising the multicomponent reaction in an organic solvent and in the presence of a protic or Lewis acid between compounds of general formula (II), (III) and (IV):

10. A pharmaceutical composition comprising a compound of claim 1 or a pharmaceutically acceptable salt thereof, and at least a pharmaceutically acceptable carrier, additive, adjuvant or vehicle.