Gastroretentive tablets
The present invention relates to a gastroretentive tablet comprising pregabalin, at least one swellable polymer, and other pharmaceutically acceptable excipients. It further relates to a process for the preparation of same.
1. A gastroretentive tablet comprising pregabalin, at least one swellable polymer, and other pharmaceutically acceptable excipients.
2. The gastroretentive tablet according to claim 1 , wherein the tablet further comprises a gas generating agent.
3. The gastroretentive tablet according to claim 1 , wherein the other pharmaceutically acceptable excipients are selected from diluents, binders, disintegrants, glidants, lubricants, and coloring agents.
4. The gastroretentive tablet according to claim 1 , wherein the swellable polymer is selected from cellulose polymers, gums, polyethylene oxide, carbomer, superdisintegrant polymers, and combinations thereof.
5. The gastroretentive tablets according to claim 2 , wherein the gas generating agent is selected from carbonates, bicarbonates, sufites, and mixtures thereof.
6. The gastroretentive tablet according to claim 5 , wherein the gas generating agent additionally comprises an acid source.
7. The gastroretentive tablet according to claim 1 , wherein the tablet additionally comprises a matrix forming agent.
8. The gastroretentive tablet according to claim 7 , wherein the matrix forming agent is a formulated mixture of polyvinyl acetate and polyvinylpyrrolidone.
9. A process for the preparation of a gastroretentive tablet comprising pregabalin, at least one swellable polymer, and other pharmaceutically acceptable excipients selected from diluents, binders, disintegrants, glidants, lubricants, and coloring agents, wherein the process comprises the conventional methods of dry granulation, wet granulation, and direct compression.
10. The process according to claim 9 , wherein the process includes using a gas generating agent.