Treating human immunodeficiency virus infections
View Patent ↗Methods and compositions for determining a prognosis for a subject infected with HIV, reducing a risk of an HIV infection, and treating or reducing a risk of developing AIDS are described.
1. A method of treating AIDS in a subject or reducing a risk of developing AIDS in a HIV-infected subject, the method comprising administering to the subject a therapeutically effective amount of step loop binding protein (SLBP), thereby treating AIDS in the subject, or reducing the risk of developing AIDS in the HIV-infected subject.
2. The method of claim 1 , the method further comprising selecting the subject for administration of a therapeutically effective amount of SLBP, wherein selecting the subject comprises:
providing a sample from the subject;
assaying the sample to determine a level of SLBP in the sample to obtain a test value;
comparing the test value to a reference value; and
selecting the subject if the test value is less than or about the same as the reference value.
3. The method of claim 1 , wherein the SLBP is administered to the patient intraperitoneally, intramusclularly, by infusion, vaginally, rectally, or orally.
4. The method of claim 1 , the method further comprising treating the subject with an anti-retroviral therapy.
5. The method of claim 4 , wherein the anti-retroviral therapy is selected from the group consisting of an entry inhibitor, a CCR5 receptor antagonist, a reverse-transcriptase inhibitor, a protease inhibitor, an integrase inhibitor, and a maturation inhibitor.
6. The method of claim 2 , wherein the sample comprises serum, plasma, or blood.