Inhibitors of histone demethylases

1. A compound of the Formula (I)

wherein

Q is selected from —CH═NR 12 , —W, —CH 2 NHR 13 , and —CH═O;

A is selected from —CH 2 C(O)—, C 1-8 alkylene, and C 2-8 alkenylene, which C 1-8 alkylene and C 2-8 alkenylene may optionally be substituted with one or more R 3 ;

Y is selected from —NR 6 R 7 , —OR 7 , C 1-8 alkyl, C 3-10 cycloalkyl, heterocyclyl, and aryl, which C 1-8 alkyl, C 3-10 cycloalkyl, heterocyclyl, and aryl may optionally be substituted with one or more R 3 ;

R 1 is selected from —H and C 1-8 alkyl;

each R 3 is independently selected from C 1-6 alkyl, C 1-4 hydroxyalkyl, C 3-10 cycloalkyl, —Z-heterocyclyl, —Z-aryl, NR 6 R 7 , —Z—OR 7 , halogen, and —Z—SR 7 , wherein any aryl may be substituted with one or more R 5 ;

each Z is independently selected from a single bond and C 1-4 alkylene;

each R 5 is independently selected from C 1-6 alkyl and C 1-4 alkoxy;

each of R 6 and R 7 is independently selected from —H, C 1-8 alkyl, C 1-4 fluoroalkyl, C 1-4 perfluoroalkyl, C 2-8 alkynyl, C 3-10 cycloalkyl, —Z-heterocyclyl, and —Z-aryl, which C 1-8 alkyl, heterocyclyl, and aryl may optionally be substituted with one or more independently selected R 8 ; or, alternatively, R 6 and R 7 may together with the N-atom to which they are attached form an N-heterocyclic ring optionally substituted with one or more independently selected R 8 ;

each R 8 is independently selected from C 1-6 alkyl, C 3-10 cycloalkyl, —Z-heterocyclyl, —Z-aryl, —Z—NR 10 R 11 , halogen, and —CN, which C 3-10 cycloalkyl, heterocyclyl, and aryl may optionally be substituted with one or more selected from C 1-4 alkyl, —Z—NR 10 R 11 , —Z—OR 9 , halogen, and —Z—SOR 9 ;

each R 9 is independently selected C 1-8 alkyl; and

each of R 10 and R 11 is independently selected C 1-6 alkyl, or, alternatively, R 10 and R 11 may together with the N-atom to which they are attached form an N-heterocyclic ring;

with the proviso that Y is not H when A is —CH 2 —;

when Q is —CH═NR 12 , R 12 is selected from C 1-10 alkyl, C 3-10 cycloalkyl, —Z-aryl, —Z—NR 6 R 7 , and —Z—OR 7 , which C 1-10 alkyl, C 3-10 cycloalkyl, and aryl may optionally be substituted with one or more R 3 ;

when Q is —CH 2 NHR 13 , R 13 is selected from hydrogen, —C(O)R 7 , —C(O)C(O)OR 7 , C 1-8 alkyl, and C 3-10 cycloalkyl, which C 1-8 alkyl may optionally be substituted with one or more independently selected R 8 , with the proviso that C 1-8 alkyl is not substituted with —Z-aryl;

when Q is W, W is selected from an 1,3-diaza-C 5-7 -cycloalk-2-yl group which is N-substituted with R 16 and optionally further substituted with one or more R 3 ; a 1,3-thiaza-C 5-7 -cycloalk-2-yl group which is N-substituted with R 16 and optionally further substituted with one or more R 3 ; and an 1,3-oxaza-C 5-7 -cycloalk-2-yl group which is N-substituted with R 16 and optionally further substituted with one or more R 3 wherein in all three instances two R 3 's on the same carbon atom may together form a spiro group;

R 16 is selected from hydrogen and —C(O)R 7 ; and

each aryl is phenyl and each heterocyclyl comprises 1 or 2 nitrogen atoms and 4 or 5 total ring atoms;

or an isomer or a mixture of isomers thereof, or a pharmaceutically acceptable salt, or solvate thereof.

2. A compound according to claim 1 , wherein A is selected from —CHR 2 C(O)— and C 1-8 alkylene.

3. A compound according to claim 1 , wherein Y is —NR 6 R 7 .

4. A compound according to claim 3 , wherein A is —CHR 2 C(O)—.

5. A compound according to claim 4 , wherein A is —CH 2 C(O)—.

6. A compound according to claim 2 , wherein Y is

wherein n is from 1 to 3 and each of R 6 , R 10 and R 11 independently is as defined in claim 1 .

7. A compound according to claim 6 , wherein Y is

wherein n is from 1 to 3 and each of R 10 and R 11 independently is as defined in claim 1 .

8. A compound according to claim 6 , wherein Y is

wherein n is from 1 to 3 and each m independently is from 0 to 2.

9. A compound according to claim 1 , wherein Y is selected from heterocyclyl and aryl, each of which may be optionally substituted with one or more R 3 .

10. A compound according to claim 1 , wherein R 13 is H.

11. A compound according to claim 1 , wherein Q is of the formula

wherein R 18 and R 19 are hydrogen, or together form a 1,3-diaza-C 5-7 -cycloalk-2-yl group which is N-substituted with R 16 and optionally further substituted with one or more R 3 ; a 1,3-thiaza-C 5-7 -cycloalk-2-yl group which is N-substituted with R 16 and optionally further substituted with one or more R 3 ; an 1,3-oxaza-C 5-7 -cycloalk-2-yl group which is N-substituted with R 16 and optionally further substituted with one or more R 3 , wherein in all three instances two R 3 's on the same carbon atom may together form a spiro group.

12. A compound selected from

N-{[2-({[4-(diethylamino)butyl]amino}methyl)pyridin-4-yl]methyl}-2,2,2-trifluoroacetamide;

[2-({[4-(dimethylamino)butyl]amino}methyl)pyridin-4-yl]methanamine;

[2-({[3-(dimethylamino)propyl]amino}methyl)pyridin-4-yl]methanamine;

2-({[4-(aminomethyl)pyridin-2-yl]methyl}amino)-N-[2-(dimethylamino)ethyl]-N-ethylacetamide;

[2-({[4-(diethylamino)butyl]amino}methyl)pyridin-4-yl]methanamine;

N-[4-(diethylamino)butyl]-2,2,2-trifluoro-N-({4-[(trifluoroacetamido)methyl]pyridin-2-yl}methyl)acetamide;

[2-({[4-(azetidin-1-yl)butyl]amino}methyl)pyridin-4-yl]methanamine;

[2-({[5-(dimethylamino)pentyl]amino}methyl)pyridin-4-yl]methanamine;

2-({[4-(aminomethyl)pyridin-2-yl]methyl}amino)-N-{1-[(2-methoxyphenyl)methyl]piperidin-4-yl}acetamide;

N-{[2-({[4-(dimethylamino)butyl]amino}methyl)pyridin-4-yl]methyl}cyclopropanamine;

N-{[2-({[3-(2-methylpiperidin-1-yl)propyl]amino}methyl)pyridin-4-yl]methyl}cyclopropanamine;

N-({2-[(propylamino)methyl]pyridin-4-yl}methyl)cyclopropanamine;

2-{[(4-{[(cyanomethyl)amino]methyl}pyridin-2-yl)methyl]amino}-N,N-dimethylacetamide;

2-{[(4-{[(2-fluoroethyl)amino]methyl}pyridin-2-yl)methyl]amino}-N,N-dimethylacetamide;

2-({[4-({[2-(dimethylamino)ethyl]amino}methyl)pyridin-2-yl]methyl}amino)-N,N-dimethylacetamide;

{[(2S)-1-benzylpyrrolidin-2-yl]methyl}[(4-{[(cyclopropylmethyl)amino]methyl}pyridin-2-yl)methyl]amine;

benzyl(methyl) {3-[({4-[(methylamino)methyl]pyridin-2-yl}methyl)amino]propyl}amine;

benzyl[3-({[4-({[2-(dimethylamino)ethyl]amino}methyl)pyridin-2-yl]methyl}amino)propyl]methylamine;

benzyl(3-{[(4-{[(2-methoxyethyl)amino]methyl}pyridin-2-yl)methyl]amino}propyl)methylamine;

2-[({4-[(cyclopropylamino)methyl]pyridin-2-yl}methyl)amino]-N-{1-[(2-methoxyphenyl)methyl]piperidin-4-yl}acetamide;

2-cyclopropyl-2-({[2-({[2-(dimethylamino)ethyl]amino}methyl)pyridin-4-yl]methyl}amino)acetonitrile;

2-({[2-({[3-(dimethylamino)propyl]amino}methyl)pyridin-4-yl]methyl}amino)propanenitrile;

2-[({2-[({4-[benzyl(cyclopropyl)amino]butyl}amino)methyl]pyridin-4-yl}methyl)amino]acetonitrile;

2-[2-({[3-(dimethylamino)propyl]amino}methyl)pyridin-4-yl]-2-(methylamino)acetonitrile;

N-[(2-{[({[2-(dimethylamino)ethyl](ethyl)carbamoyl}methyl)amino]methyl}pyridin-4-yl)methyl]-2,2,2-trifluoroacetamide;

N-[(2-{[N-({[2-(dimethylamino)ethyl](ethyl)carbamoyl}methyl)-2,2,2-trifluoroacetamido]methyl}pyridin-4-yl)methyl]-2,2,2-trifluoroacetamide;

({[2-({[4-(diethylamino)butyl]amino}methyl)pyridin-4-yl]methyl}carbamoyl)formic acid;

tert-butyl ({[2-({[4-(diethylamino)butyl]amino}methyl)pyridin-4-yl]methyl}carbamoyl)formate;

ethyl 2-({[(2-{[({[2-(dimethylamino)ethyl](ethyl)carbamoyl}methyl)amino]methyl}pyridin-4-yl)methyl]carbamoyl}oxy)benzoate;

N-[(2-{[({[2-(azetidin-1-yl)ethyl](ethyl)carbamoyl}methyl)amino]methyl}pyridin-4-yl)methyl]-2,2,2-trifluoroacetamide;

N-[(2-{[({[2-(dimethylamino)ethyl](ethyl)carbamoyl}methyl)amino]methyl}pyridin-4-yl)methyl]-2,2,3,3,4,4,4-heptafluorobutanamide;

N-[(2-{[({[2-(dimethylamino)ethyl](ethyl)carbamoyl}methyl)amino]methyl}pyridin-4-yl)methyl]-2,2-difluorobutanamide;

2-[({4-[(N-cyclopropylcarboximidoyl]pyridin-2-yl}methyl)amino]-N,N-dimethylacetamide;

N,N-dimethyl-2-[({4-[[(3-phenylpropyl)imino]methyl]pyridin-2-yl}methyl)amino]acetamide;

N,N-dimethyl-2-[({4-[N-(2-methylcyclopropyl)carboximidoyl]pyridin-2-yl}methyl)amino]acetamide;

2-[({4-[[(2-cyclohexylethyl)imino]methyl]pyridin-2-yl}methyl)amino]-N,N-dimethylacetamide;

[3-(dimethylamino)propyl]({4-[{[3-(dimethylamino)propyl]imino}methyl]pyridin-2-yl}methyl)amine;

({4-[{[2-(dimethylamino)ethyl]imino}methyl]pyridin-2-yl}methyl) [3-(dimethylamino)propyl]amine;

N-{[2-({[2-(ethylsulfanyl)ethyl]amino}methyl)pyridin-4-yl]methylidene}cyclopropanamine;

N-{[2-({[2-(1-methylpyrrolidin-2-yl)ethyl]amino}methyl)pyridin-4-yl]methylidene}cyclopropanamine;

N-({2-[({3-[benzyl(methyl)amino]propyl}amino)methyl]pyridin-4-yl}methylidene)cyclopropanamine;

N-{[2-({[3-(pyrrolidin-1-yl)propyl]amino}methyl)pyridin-4-yl]methylidene}cyclopropanamine;

N-{[2-({[(2E)-4-(dimethylamino)but-2-en-1-yl]amino}methyl)pyridin-4-yl]methylidene}cyclopropanamine;

N-{[2-({[4-(azetidin-1-yl)butyl]amino}methyl)pyridin-4-yl]methylidene}cyclopropanamine;

N-{[2-({[4-(dimethylamino)butyl]amino}methyl)pyridin-4-yl]methylidene}cyclopropanamine;

N-[(2-{[({4-[(dimethylamino)methyl]cyclohexyl}methyl)amino]methyl}pyridin-4-yl)methylidene]cyclopropanamine;

N-{[2-({[5-(dimethylamino)pentyl]amino}methyl)pyridin-4-yl]methylidene}cyclopropanamine;

2-[({4-[N-cyclopropylcarboximidoyl]pyridin-2-yl}methyl)amino]-N-[4-(diethylamino)butyl]acetamide;

2-[({4-[N-cyclopropylcarboximidoyl]pyridin-2-yl}methyl)amino]-1-[(2R)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]ethan-1-one;

N-(2-cyanoethyl)-2-[({4-[N-cyclopropylcarboximidoyl]pyridin-2-yl}methyl)amino]-N-ethylacetamide;

2-[({4-[N-cyclopropylcarboximidoyl]pyridin-2-yl}methyl)amino]-N-[(1-ethylpyrrolidin-2-yl)methyl]acetamide;

2-[({4-[N-cyclopropylcarboximidoyl]pyridin-2-yl}methyl)amino]-N-methyl-N-[3-(1H-pyrazol-1-yl)propyl]acetamide;

N-(1-benzylpyrrolidin-3-yl)-2-[({4-[N-cyclopropylcarboximidoyl]pyridin-2-yl}methyl)amino]acetamide;

2-[({4-[N-cyclopropylcarboximidoyl]pyridin-2-yl}methyl)amino]-1-(4-methylpiperazin-1-yl)ethan-1-one;

1-(4-benzylpiperidin-1-yl)-2-[({4-[N-cyclopropylcarboximidoyl]pyridin-2-yl}methyl)amino]ethan-1-one;

2-[({4-[N-cyclopropylcarboximidoyl]pyridin-2-yl}methyl)amino]-N-methyl-N-(prop-2-yn-1-yl)acetamide;

2-[({4-[[(2-cyclohexylethyl)imino]methyl]pyridin-2-yl}methyl)amino]-N,N-diethylacetamide;

N,N-diethyl-2-[({4-[(octylimino)methyl]pyridin-2-yl}methyl)amino]acetamide methyl

2-[({4-[N-cyclopropylcarboximidoyl]pyridin-2-yl}methyl)amino]acetate;

[4-(diethylamino)butyl]({4-[[(2-methoxyethyl)imino]methyl]pyridin-2-yl}methyl)amine;

2-[{[2-({[4-(diethylamino)butyl]amino}methyl)pyridin-4-yl]methylidene}amino]ethan-1-ol;

{[2-({[4-(diethylamino)butyl]amino}methyl)pyridin-4-yl]methylidene}(2,2,3,3,3-pentafluoropropyl)amine;

2-[({4-[[(2-cyclohexylethyl)imino]methyl]pyridin-2-yl}methyl)amino]-N-[2-(dimethylamino)ethyl]-N-ethylacetamide;

[3-(dimethylamino)propyl]({4-[(methoxyimino)methyl]pyridin-2-yl}methyl)amine;

[4-(diethylamino)butyl]({[4-(1-methylimidazolidin-2-yl)pyridin-2-yl]methyl})amine;

N-[2-(dimethylamino)ethyl]-N-ethyl-2-[({4-[([(2-hydroxyethyl)imino]methyl]pyridin-2-yl}methyl)amino]acetamide;

(2-cyclohexylethyl)({[2-({[4-(diethylamino)butyl]amino}methyl)pyridin-4-yl]methylidene})amine;

[4-(diethylamino)butyl]({[4-(1-methyl-1,3-diazinan-2-yl)pyridin-2-yl]methyl})amine;

N,N-diethyl-2-[({4-[{[2-(4-methylphenyl)ethyl]imino}methyl]pyridin-2-yl}methyl)amino]acetamide;

4-[2-{[2-({[4-(diethylamino)butyl]amino}methyl)pyridin-4-yl]methylidene}hydrazin-1-yl]benzonitrile;

3-[{[2-({[4-(diethylamino)butyl]amino}methyl)pyridin-4-yl]methylidene}amino]propan-1-ol;

[4-(diethylamino)butyl][(4-{7-oxa-9-azaspiro[4.5]decan-8-yl}pyridin-2-yl)methyl]amine;

2-[{[2-({[4-(diethylamino)butyl]amino}methyl)pyridin-4-yl]methylidene}amino]propan-1-ol;

1-[{[2-({[4-(diethylamino)butyl]amino}methyl)pyridin-4-yl]methylidene}amino]propan-2-ol;

2-[{[2-({[4-(diethylamino)butyl]amino}methyl)pyridin-4-yl]methylidene}amino]-2-phenylethan-1-ol;

3-[{[2-({[4-(diethylamino)butyl]amino}methyl)pyridin-4-yl]methylidene}amino]-2,2-dimethylpropan-1-ol;

(1-{[{[2-({[4-(diethylamino)butyl]amino}methyl)pyridin-4-yl]methylidene}amino]methyl}cyclopropyl)methanol;

N-[2-(dimethylamino)ethyl]-N-ethyl-2-[({4-[[(3-hydroxypropyl)imino]methyl]pyridin-2-yl}methyl)amino]acetamide;

N-ethyl-2-[({4-[[(2-hydroxyethyl)imino]methyl]pyridin-2-yl}methyl)amino]-N-[(1-methylpyrrolidin-2-yl)methyl]acetamide;

2-{[{[2-({[4-(diethylamino)butyl]amino}methyl)pyridin-4-yl]methylidene}amino]methyl}-3-phenylpropan-1-ol;

2-[({4-[[(2-cyclohexyl-3-hydroxypropyl)imino]methyl]pyridin-2-yl}methyl)amino]-N-[2-(dimethylamino)ethyl]-N-ethylacetamide;

N-[3-(dimethylamino)propyl]-N-ethyl-2-[({4-[[(2-hydroxyethyl)imino]methyl]pyridin-2-yl}methyl)amino]acetamide;

N-[2-(dimethylamino)propyl]-N-ethyl-2-[({4-[[(2-hydroxyethyl)imino]methyl]pyridin-2-yl}methyl)amino]acetamide;

1-[{[2-({[4-(diethylamino)butyl]amino}methyl)pyridin-4-yl]methylidene}amino]-3-phenylpropan-2-ol;

N-{[(1S,2S)-2-(dimethylamino)cyclopentyl]methyl}-N-ethyl-2-[({4-[[(2-hydroxyethyl)imino]methyl]pyridin-2-yl}methyl)amino]acetamide;

2-[({4-[{[3-(dimethylamino)-2-hydroxypropyl]imino}methyl]pyridin-2-yl}methyl)amino]-N-[2-(dimethylamino)ethyl]-N-ethylacetamide;

2-({[4-(5,5-dimethyl-1,3-oxazinan-2-yl)pyridin-2-yl]methyl}amino)-N-[2-(dimethylamino)ethyl]-N-ethylacetamide;

N-[2-(dimethylamino)ethyl]-N-ethyl-2-[({4-[({[1-(hydroxymethyl)cyclopropyl]methyl}imino)methyl]pyridin-2-yl}methyl)amino]acetamide;

2-[({4-[[(2-benzyl-3-hydroxypropyl)imino]methyl]pyridin-2-yl}methyl)amino]-N-[2-(dimethylamino)ethyl]-N-ethylacetamide;

2-[({4-[5-benzyl-3-(trifluoroacetyl)-1,3-oxazinan-2-yl]pyridin-2-yl}methyl)amino]-N-[2-(dimethylamino)ethyl]-N-ethylacetamide;

N-[2-(dimethylamino)ethyl]-N-ethyl-2-[({4-[7-(trifluoroacetyl)-5-oxa-7-azaspiro[2.5]octan-6-yl]pyridin-2-yl}methyl)amino]acetamide;

N-[(2-fluorophenyl)methyl]-2-[({4-[[(2-hydroxyethyl)imino]methyl]pyridin-2-yl}methyl)amino]-N-methylacetamide;

2-[({2-[({2-[2-(benzyloxy)phenyl]ethyl}amino)methyl]pyridin-4-yl}methylidene)amino]ethan-1-ol;

N-(2-cyanoethyl)-N-ethyl-2-[({4-[[(2-hydroxyethyl)imino]methyl]pyridin-2-yl}methyl)amino]acetamide;

(2 S)-2-[({4-[[(2-hydroxyethyl)imino]methyl]pyridin-2-yl}methyl)amino]-4-methyl-1-(piperidin-1-yl)pentan-1-one;

2-[{4-[([(2-hydroxyethyl)imino]methyl]pyridin-2-yl}methyl)amino]-N-methyl-N-(2-phenylethyl)acetamide;

2-{[({4-[(dimethylamino)methyl]cyclohexyl}methyl)amino]methyl}pyridine-4-carbaldehyde;

2-({[(2E)-4-(dimethylamino)but-2-en-1-yl]amino}methyl)pyridine-4-carbaldehyde;

2-({[(2Z)-4-(dimethylamino)but-2-en-1-yl]amino}methyl)pyridine-4-carbaldehyde;

2-({[(1-methylpiperidin-4-yl)methyl]amino}methyl)pyridine-4-carbaldehyde;

N-[2-(dimethylamino)ethyl]-N-ethyl-2-{[(4-formylpyridin-2-yl)methyl]amino}acetamide;

2-[({2-oxo-2-[(2R)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]ethyl}amino)methyl]pyridine-4-carbaldehyde;

2-({[2-(4-methylpiperazin-1-yl)-2-oxoethyl]amino}methyl)pyridine-4-carbaldehyde;

N-[(1-ethylpyrrolidin-2-yl)methyl]-2-{[(4-formylpyridin-2-yl)methyl]amino}acetamide;

N,N-diethyl-2-{[(4-formylpyridin-2-yl)methyl]amino}acetamide;

2-({[2-(4-benzylpiperidin-1-yl)-2-oxoethyl]amino}methyl)pyridine-4-carbaldehyde;

2-({[4-(diethylamino)butyl]amino}methyl)pyridine-4-carbaldehyde;

2-({[4-(dimethylamino)butyl]amino}methyl)pyridine-4-carbaldehyde;

2-[({4-[benzyl(cyclopropyl)amino]butyl}amino)methyl]pyridine-4-carbaldehyde;

2-({[2-(dimethylamino)ethyl]amino}methyl)pyridine-4-carbaldehyde;

2-({[3-(pyrrolidin-1-yl)propyl]amino}methyl)pyridine-4-carbaldehyde;

N-[4-(diethylamino)butyl]-2-{[(4-formylpyridin-2-yl)methyl]amino}acetamide;

N-(1-benzylpyrrolidin-3-yl)-2-{[(4-formylpyridin-2-yl)methyl]amino}acetamide;

2-({[5-(dimethylamino)pentyl]amino}methyl)pyridine-4-carbaldehyde;

N-[4-(diethylamino)butyl]-2,2,2-trifluoro-N-[(4-formylpyridin-2-yl)methyl]acetamide;

N-[2-(diethylamino)ethyl]-N-ethyl-2-{[(4-formylpyridin-2-yl)methyl]amino}acetamide;

2-[({[3-(dimethylamino)cyclopentyl]methyl}amino)methyl]pyridine-4-carbaldehyde;

N-[2-(dimethylamino)-2-methylpropyl]-N-ethyl-2-{[(4-formylpyridin-2-yl)methyl]amino}acetamide;

N-ethyl-2-{[(4-formylpyridin-2-yl)methyl]amino}-N-[(1-methylpyrrolidin-2-yl)methyl]acetamide;

2-({methyl[2-oxo-2-(piperidin-1-yl)ethyl]amino}methyl)pyridine-4-carbaldehyde;

and pharmaceutically acceptable salts thereof.

13. A compound according to claim 12 , in the form of an oxalate salt.

14. A compound according to claim 12 , in the form of a citrate salt.

15. A compound according to claim 12 , in the form of a fumarate salt.

16. A compound according to claim 12 , in the form of an ascorbate salt.

17. A pharmaceutical composition comprising at least one compound of claim 1 and one or more pharmaceutically acceptable excipients, diluents or carriers.

18. A pharmaceutical composition according to claim 17 , which comprises one or more further active substances.

19. A method of treating cancer in a subject, comprising administering to said subject a therapeutically effective amount of at least one compound of claim 1 , wherein the cancer is squamous cell carcinoma.

20. The method of claim 19 , wherein the squamous cell carcinoma is located in the skin, lips, mouth, esophagus, urinary bladder, prostate, lungs, vagina, or cervix.

21. A method of treating cancer in a subject, comprising administering to said subject a therapeutically effective amount of at least one compound of claim 12 , wherein the cancer is squamous cell carcinoma.

22. The method of claim 21 , wherein the squamous cell carcinoma is located in the skin, lips, mouth, esophagus, urinary bladder, prostate, lungs, vagina, or cervix.

23. A method of treating cancer in a subject, comprising administering to said subject a therapeutically effective amount of at least one compound of claim 1 , wherein the cancer is selected from the group consisting of leukemia, lymphoma, oral cancer, laryngeal cancer, esophageal cancer, prostate cancer, bladder cancer, renal cancer, uterine cancer, ovarian cancer, testicular cancer, rectal cancer, colon cancer, lung cancer, brain cancer, breast cancer, pancreatic cancer, stomach cancer, liver cancer, thyroid cancer, melanoma, and multiple myeloma.

24. A method of treating cancer in a subject, comprising administering to said subject a therapeutically effective amount of at least one compound of claim 12 , wherein the cancer is selected from the group consisting of leukemia, lymphoma, oral cancer, laryngeal cancer, esophageal cancer, prostate cancer, bladder cancer, renal cancer, uterine cancer, ovarian cancer, testicular cancer, rectal cancer, colon cancer, lung cancer, brain cancer, breast cancer, pancreatic cancer, stomach cancer, liver cancer, thyroid cancer, melanoma, and multiple myeloma.

25. A method for inhibiting a histone demethylase, comprising contacting a cell with a compound of claim 1 in an amount effective to produce a concentration sufficient to inhibit the demethylation of a histone in a cell.

26. The method of claim 25 , wherein the histone demethylase is a member of the KDM6 family, KDM5 family, KDM4 family, KDM3 family, or KDM2 family.

27. A method for inhibiting a histone demethylase, comprising contacting a cell with a compound of claim 12 in an amount effective to produce a concentration sufficient to inhibit the demethylation of a histone in a cell.

28. The method of claim 27 , wherein the histone demethylase is a member of the KDM6 family, KDM5 family, KDM4 family, KDM3 family, or KDM2 family.