Method for predicting the risk of a subject for contracting diabetes mellitus and/or metabolic syndrome or for diagnosing metabolic syndrome in a subject
Subject matter of the present invention is a method for predicting the risk of a subject for contracting diabetes mellitus and/or metabolic syndrome or for diagnosing metabolic syndrome in a subject wherein said subject is non-diabetic, comprising the following steps determining the level of pro-neurotensin or fragments thereof of at least 5 amino acids in a bodily fluid obtained from said subject; and correlating said level of pro-neurotensin or fragments thereof with the risk of said subject for contracting diabetes mellitus and/or metabolic syndrome, wherein an elevated level is predictive for an enhanced risk of getting diabetes mellitus and/or metabolic syndrome, or wherein an elevated level correlates to the diagnosis of metabolic syndrome in a subject wherein said subject is non-diabetic.
1. A method comprising
contacting a sample of a bodily fluid from a fasting non-diabetic subject with a level pro-neurotensin 1-117 of 78 pmol/1 or above with an antibody that binds to pro-neurotensin 1-117 and administering a dietary measure to reduce the fat uptake of said fasting non-diabetic subject to lower the risk of contracting diabetes mellitus and/or metabolic syndrome.
2. A method of claim 1 wherein the sample of bodily fluid is selected from the group consisting of a blood sample a plasma sample, a cerebrospinal fluid sample, a serum sample, a urine sample or an extract of the aforementioned samples.
3. A method according to claim 1 , wherein the sample of bodily fluid is from a subject which is a fasting non-diabetic and non-prediabetic (non-IFG) subject.
4. A method according to claim 1 , wherein the blood sample has a blood glucose level of less than 6.1 mmol/l but more than 5.4 mmol/l.
5. A method according to claim 1 , wherein the blood sample has a blood glucose level of less than 5.4 mmol/l.
6. A method according to claim 1 wherein said antibody is full-length immunoglobulin, or fragments therein containing at least the F-variable domain of heavy and/or light chain.
7. A method according to claim 1 wherein the level of pro-neurotensin 1-117 in the bodily fluid is between 78-150 pmol/l.
8. A method according to claim 1 wherein the level of pro-neurotensin 1-117 in the bodily fluid is 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94 95, 96 97 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149 or 150 pmol/l.