IP Library Granted Patent US 10,139,423
Granted Patent B2
US 10,139,423 · App. 14/383,749 · Granted Nov 27, 2018

Medical analysis method

Inventors: Jean-Michel Brisebat (Villers, FR); Sébastien Bernay (Ecoche, FR); Cédric Gagnepain (Riorges, FR); Daniel Seydoux (Le Mesnil Saint Denis, FR)
Assignees: BIO-RAD INNOVATIONS; DiaMed GmbH
G01N35/0099G01N35/1081G01N35/109Y10S901/31Y10T436/114165
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Quick Facts
Patent No.
US 10,139,423
App. No.
14/383,749
Filed
Sep 8, 2014
Granted
Nov 27, 2018
Kind
B2
Art Unit
1798
USPC
422/65
Abstract

A medical analysis method uses a medical analysis machine provided with a poly-articulated robot ( 70 ) comprising joints defining at least six axes of rotation (A 1 , A 2 , A 3 , A 4 , A 5 , A 6 ) and adapted for spacing and/or orienting a terminal member ( 66 ) according to six degrees of freedom, the terminal member bearing a grasping member ( 78 ) adapted for grasping a container ( 16 ). The medical analysis method comprises at least the succession of steps consisting of providing a container ( 16 ) containing a sample to be treated stemming from a human being or an animal, transferring said container ( 16 ) towards at least one treatment station of the medical analysis machine ( 100 ) by means of the poly-articulated robot, treating the sample in a treatment station, transferring the container towards a station for capturing images, and displaying the treatment results through a user interface.

Claims (30)

1. A medical analysis method using a medical analysis machine provided with a poly-articulated robot comprising joints defining at least six axes of rotation and adapted for displacing and/or orienting a terminal member according to six degrees of freedom, the terminal member bearing a grasping member adapted for grasping a container, said medical analysis method comprising at least the succession of the following steps:

providing a container filled beforehand with a sample to be treated stemming from a human being or an animal, said sample is one of a type comprising a liquid, biological tissue, or organ tissue from a human being or an animal, said container being a gel card including a body in which are formed several adjacent reaction wells positioned along a single row, the wells containing a gel and being initially obturated with a lid, the grasping member of the poly-articulated robot being configured to grasp and displace such a gel card,

transferring said container, by means of the poly-articulated robot moving at a first speed, to at least one treatment station of the medical analysis machine,

treating the sample in the treatment station while maintaining the sample within the container, and

transferring the container, by means of the poly-articulated robot moving at a second speed, to a station for capturing images of the treated sample and determine the type of sample in said container, wherein the first speed and the second speed are controlled based on the type of the sample disposed within the container so as to avoid overflow or stirring of the liquid, and determining, automatically with the medical analysis machine and based at least in part on the images, whether treating the sample resulted in a positive reaction within the container or a negative reaction within the container,

the method further comprising a prior parameterization step including:

sensing respective coordinates of different stations of the medical analysis machine using a piezo-electric sensing device of the terminal member, and wherein the coordinates are stored in a memory associated

with the medical analysis machine, and

defining, based at least in part on the respective coordinates, first and second areas of the medical analysis machine, wherein

the first areas comprise areas, including the at least one treatment station and the station for capturing images, where the poly-articulated robot is allowed to move, and

the second areas comprise areas different from the first areas, the at least one treatment station, and the station for capturing images, the poly-articulated robot being prohibited from passing horizontally over the second areas of the medical analysis machine.

2. The medical analysis method according to claim 1 , wherein the step for treating the sample comprises the introduction into the container of a reagent adapted to react with the sample to be treated.

3. The medical analysis method according to claim 1 , comprising a prior step during which the sample is extracted from a storage receptacle and introduced into the container by means of the poly-articulated robot.

4. The method according to claim 1 , wherein the poly-articulated robot is secured to a fixed base and exclusively comprises rotoidal joints.

5. The analysis method according to claim 1 , wherein the medical analysis performed belongs to any of the fields from among immune-hematology, virology, microbiology, bacteriology, mycology, parasitology, quality control for an in vitro diagnostic laboratory, detection of auto-immune diseases, monitoring diabetes, detecting genetic diseases, toxicology and the monitoring of a physiological or pathological condition, subsequent to therapeutic treatment.

6. The method according to claim 1 , wherein the container is brought to the station for capturing images of the treatment results by means of the poly-articulated robot.

7. The method according to claim 1 , during the transfer step, the container is brought by means of the poly-articulated robot to a control station of the medical analysis machine.

8. The method according to claim 7 , wherein the station for capturing images of the treatment results and the control station are a single and same station.

9. The medical analysis method according to claim 1 , wherein:

the container filled beforehand with the sample to be treated by means of the poly-articulated robot is brought to an area for pipetting said container in order to introduce a reagent therein,

the reagent is introduced into the container,

the container is brought to an incubator by means of the poly-articulated robot,

the container is incubated,

the container is brought by means of the poly-articulated robot from the incubator to a centrifuge,

the container is centrifuged,

the container is transferred to the station for capturing images.

10. The method according to claim 9 , wherein, before the step of introducing the reagent into the container, a reagent flask is turned upside down and/or shaken by means of the poly-articulated robot, the reagent being thereby resuspended.

11. The analysis method according to claims 9 , wherein before the centrifugation step, the container is brought, by means of the poly-articulated robot, to a control station where the container is viewed in order to check the air gaps.

12. The method according to claim 1 , wherein the container is brought, by means of the poly-articulated robot, to a collecting container intended for recovering the waste.

13. The method according to claim 1 , wherein the machine comprises a plurality of treatment stations which are distributed over 360° around the poly-articulated robot.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 22, 2021
From: BIO-RAD INNOVATIONS
To: BIO-RAD EUROPE GMBH
Reel/Frame 056019/0624 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 20, 2019
From: DIAMED GMBH
To: BIO-RAD EUROPE GMBH
Reel/Frame 050108/0806 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 25, 2016
From: BRISEBRAT, JEAN-MICHEL; BERNAY, SEBASTIEN; GAGNEPAIN, CEDRIC; SEYDOUX, DANIEL
To: DIAMED GMBH; BIO-RAD INNOVATIONS
Reel/Frame 037825/0702 →
Priority Claims (1)
FR 12 52116 · Mar 8, 2012 · national
Continuity (1)
Related Publication 20150111198A1 · Apr 23, 2015
Cited By (2)
US 12,370,125 US 12,414,899