IP Library › Granted Patent US 12,370,125
Granted Patent B2
US 12,370,125 · App. 18/424,187 · Granted Jul 29, 2025

Fluid transfer station in a robotic pharmaceutical preparation system

Inventors: Eric Shem-Tov (Ramat Hasharon, IL); Marino Kriheli (Savion, IL); Boaz Slav (Haifa, IL); Raanan Tavor (Yuvalim, IL); Gonen Daskal (Akersberga, SE)
Assignee: EQUASHIELD MEDICAL LTD
A61J1/2055A61J1/1406A61J1/2089A61J1/2096B25J13/08B65B3/003A61J2200/70
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Quick Facts
Patent No.
US 12,370,125
App. No.
18/424,187
Granted
Jul 29, 2025
Kind
B2
Abstract

A robotic system and method are provided for transfer of fluid between a container accessible via a container-septum and a fluid transfer assembly accessible via a fluid transfer connector septum. The robotic system includes a controller and a manipulator controllable by the controller to manipulate at least one of the container and the fluid transfer assembly. The controller is configured to operate the manipulator to secure contact between the container-septum and the fluid transfer connector septum during at least a portion of the transfer of the fluid.

Claims (44)

1. A fluid transfer connector, comprising:

a body member couplable to a fluid transfer unit at a unit coupling portion, the body member being shaped to define a body lumen;

a fluid transfer conduit extending axially from the unit coupling portion into the body lumen, the fluid transfer conduit being configured to establish fluid communication with the fluid transfer unit when the fluid transfer unit is coupled to the unit coupling portion;

a sleeve arranged coaxially relative to the body member;

a fluid transfer connector septum mounted at a distal end of the sleeve,

the sleeve and the body member being configured to move relative to each other between an extended position and a collapsed position; and

a locking mechanism configured to switch between a locked state and an unlocked state for selectively enabling and preventing the relative movement of the sleeve and the body member; and

an actuator,

wherein the locking mechanism is configured to enable the relative movement between the sleeve and the body member from the extended position to the collapsed position upon activation of the actuator accessible through an external wall of the fluid transfer connector.

2. The fluid transfer connector according to claim 1 , wherein the actuator comprises an internal portion, disposed at least partially within one of the sleeve and the body member, and an actuation portion which is accessible via an opening formed on the other one of the sleeve and the body member, and

wherein application of a radial force on the actuation portion induces actuation of the locking mechanism at least from the locked state to the unlocked state for

facilitating the movement of the body member with respect to the sleeve at least from the extended position to the collapsed position.

3. The fluid transfer connector according to claim 1 , wherein the external wall of the fluid transfer connector comprises a protective surface configured to prevent manual access to the actuator.

4. The fluid transfer connector according to claim 2 , wherein the external wall of the fluid transfer connector comprises a protective surface configured to prevent manual access to the actuator, the protective surface comprising one or more protection elements surrounding the opening.

5. The fluid transfer connector according to claim 1 , wherein a fluid transfer connector inner surface is configured for axial, slidable movement of the actuator therealong for facilitating the movement between the extended position and the collapsed position.

6. The fluid transfer connector according to claim 5 , wherein the actuator is configured:

to be pressable by a radial force, thereby switching from the locked state to the unlocked state at the extended position; and

for subsequent slidable axial movement along the inner surface for transitioning from the extended position to the collapsed position.

7. The fluid transfer connector according to claim 1 , wherein the fluid transfer connector septum comprises a throughgoing bore extending from a septum proximal surface to a septum distal surface and dimensioned for receiving the fluid transfer conduit.

8. The fluid transfer connector according to claim 1 , wherein the external wall of the fluid transfer connector comprises a peripheral wall of the sleeve and terminates at a distal edge of the peripheral wall, said peripheral wall distal edge being axially spaced away from a mounting portion of the sleeve forming a gap therebetween, said sleeve mounting portion configured to mount the fluid transfer connector septum thereon.

9. The fluid transfer connector according to claim 8 , wherein the peripheral wall is connected to the mounting portion via one or more beams.

10. The fluid transfer connector according to claim 9 , wherein the fluid transfer connector has a longitudinal axis and the one or more beams comprise two oppositely facing beams such that the septum mounting portion extends along a plane perpendicular to the longitudinal axis in between the two oppositely facing beams.

11. A fluid transfer connector, comprising:

a body member couplable to a fluid transfer unit at a unit coupling portion, the body member being shaped to define a body lumen comprising a longitudinal axis of the fluid transfer connector;

a fluid transfer conduit extending axially from the unit coupling portion into the body lumen, the fluid transfer unit being configured to establish fluid communication with the fluid transfer unit when the fluid transfer unit is coupled to the unit coupling portion;

a sleeve arranged coaxially relative to the body member and comprising a fluid transfer connector septum mounted at a distal end of the sleeve, the sleeve and the body member being configured to move relative to each other between an extended position and a collapsed position; and

a locking mechanism configured to switch between a locked state and an unlocked state for selectively enabling and preventing the relative movement of the sleeve and the body member,

wherein the locking mechanism in its locked state is configured to prevent the relative movement between the sleeve and the body member from the extended position to the collapsed position by an axial force applied on at least one of the body member and the sleeve in a direction parallel to the longitudinal axis.

12. The fluid transfer connector according to claim 11 , wherein the locking mechanism is configured to switch from the locked state to the unlocked state upon application of a radial force applied thereon in a direction perpendicular to the longitudinal axis, and to enable in its unlocked state the relative movement of the sleeve and the body member.

13. The fluid transfer connector according to claim 11 , wherein the locking mechanism comprises an actuator configured to prevent the locking mechanism from switching into its unlocked state from the locked state in response to said axial force.

14. The fluid transfer connector according to claim 13 , wherein the actuator is configured to switch the locking mechanism from the locked state into the unlocked state in response to a radial force being applied thereon.

15. The fluid transfer connector according to claim 13 , wherein the actuator comprises a lockable member and one of the sleeve and the body member comprises a locking member configured to selectively engage the lockable member in the locked state of the locking mechanism, said lockable member being at least one of: configured to prevent its release from the locking member by said axial force; and configured to be releasable from the locking member in response to said radial force.

16. The fluid transfer connector according to claim 13 , wherein the actuator comprises a lockable member and the sleeve comprises a locking member configured to selectively engage the lockable member in the locked state of the locking mechanism, said lockable member being at least one of: configured to prevent its release from the locking member by said axial force; and configured to be releasable from the locking member in response to said radial force.

17. The fluid transfer connector according to claim 13 , wherein the actuator comprises a lockable member and the body member comprises a locking member configured to selectively engage the lockable member in the locked state of the locking mechanism, said lockable member being at least one of: configured to prevent its release from the locking member by said axial force; and configured to be releasable from the locking member in response to said radial force.

18. The fluid transfer connector according to claim 13 , wherein the actuator comprises a lockable member and the sleeve or the body member comprises a locking member configured to selectively engage the lockable member in the locked state of the locking mechanism, said lockable member being configured to prevent its release from the locking member by said axial force.

19. The fluid transfer connector according to claim 13 , wherein the actuator comprises a lockable member and the sleeve or the body member comprises a locking member configured to selectively engage the lockable member in the locked state of the locking mechanism, said lockable member being configured to be releasable from the locking member in response to said radial force.

20. A fluid transfer connector, comprising:

a body member couplable to a fluid transfer unit at a unit coupling portion, the body member being shaped to define a body lumen;

a fluid transfer conduit extending axially from the unit coupling portion into the body lumen, the fluid transfer conduit being configured to establish fluid communication with the fluid transfer unit when the fluid transfer unit is coupled to the unit coupling portion;

a sleeve arranged coaxially relative to the body member;

a fluid transfer connector septum mounted at a distal end of the sleeve,

the sleeve and the body member being configured to move relative to each other between an extended position and a collapsed position; and

a locking mechanism configured to switch between a locked state and an unlocked state for selectively enabling and preventing the relative movement of the sleeve and the body member,

wherein the locking mechanism is configured to enable the relative movement between the sleeve and the body member from the extended position to the collapsed position upon activation of an actuator accessible through an external wall of the fluid transfer connector.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 15, 2025
From: KRIHELI, MARINO
To: EQUASHIELD MEDICAL LTD
Reel/Frame 070842/0596 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 29, 2024
From: SHEM-TOV, ERIC; SLAV, BOAZ; DASKAL, GONEN; TAVOR, RAANAN
To: EQUASHIELD MEDICAL LTD
Reel/Frame 066277/0314 →
Continuity (6)
Continuation 18132045 · Apr 7, 2023
Continuation 18118999 · Mar 8, 2023
Provisional Application 63429340 · Dec 1, 2022
Provisional Application 63382014 · Nov 2, 2022
Provisional Application 63269004 · Mar 8, 2022
Related Publication 20240164988A1 · May 23, 2024
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