IP Library › Granted Patent US 9,480,673
Granted Patent B2
US 9,480,673 · App. 14/388,929 · Granted Nov 1, 2016

Composition and method for treating neurodegenerative disease

Inventors: Curt R. Freed (Denver, CO); Wenbo Zhou (Denver, CO)
Assignee: The Regents of the University of Colorado, a body corporate
A61K31/216A61K31/19A61K31/192A61K31/21
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 9,480,673
App. No.
14/388,929
Granted
Nov 1, 2016
Kind
B2
Abstract

The present invention provides a method and composition for treating a neurodegenerative disease. In particular, the present invention provides a method and composition to increase DJ-1 gene expression or DJ-1 protein activity to treat a neurodegenerative disease.

Claims (4)

1. A method for treating a neurodegenerative disease in a subject in need thereof, said method comprising administering to the subject a composition comprising glycerol phenylbutyrate, wherein the neurodegenerative disease is Parkinson's disease.

2. The method of claim 1 , wherein administration of said composition increases DJ-1 protein expression by at least 50%.

3. The method of claim 1 , wherein administration of said composition increases DJ-1 protein expression by at least 100%.

4. A method for treating a neurodegenerative disease in a subject in need of such a treatment, said method comprising increasing DJ-1 expression in said subject by administering a therapeutically effective amount of glycerol phenylbutyrate, wherein increasing DJ-1 expression reduces neuron death.

Assignments (2)
CORRECTIVE ASSIGNMENT TO CORRECT THE ASSIGNEE NAME PREVIOUSLY RECORDED AT REEL: 034902 FRAME: 0221. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Apr 25, 2017
From: FREED, CURT R.; ZHOU, WENBO
To: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
Reel/Frame 042328/0858 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 6, 2015
From: FREED, CURT R.; ZHOU, WENBO
To: THE REGENTS OF THE UNIVERSITY OF COLORADO
Reel/Frame 034902/0221 →
Continuity (2)
Provisional Application 61617055 · Mar 29, 2012
Related Publication 20150087703A1 · Mar 26, 2015