Method and composition for preventing stem cell disruption and aggregation
View Patent ↗There is provided a method for preventing disruption and aggregation of stem cells. In addition, there is provided a stem cell composition for intravascular administration, in which stem cells are suspended in a solution containing aspirin. Further, there is provided a composition for preventing disruption or aggregation of stem cells, in which stem cells are suspended in a solution containing aspirin. According to the present invention, disruption and aggregation of cells may be prevented during transport or storage, such that the administered stem cells may stably reach the target tissue and exhibit the activity thereof in a more efficient manner, thereby remarkably increasing the effect of cell therapy using stem cells.
1. A method for inhibiting disruption and aggregation of stem cells, the method comprising: suspending stem cells in a solution containing aspirin in an amount effective to inhibit said disruption and aggregation.
2. The method of claim 1 , wherein said solution containing aspirin further comprises normal saline, Hartman-D solution or phosphate buffered saline (PBS).
3. The method of claim 1 , wherein the aspirin is an amount of 0.0001 to 0.01 mg/ml.
4. The method of claim 1 , wherein said stem cells are adult stem cells.
5. The method of claim 4 , wherein said stem cells are adipose tissue-derived mesenchymal stem cells (AdMSCs).