Agents and methods for treating and preventing seborrheic keratosis
Provided herein are methods and assays for isolating and culturing seborrheic keratosis cells ex vivo. Also provided herein are screening assays using cultured seborrheic keratosis cells and methods for treating seborrheic keratosis in a subject.
1. A method for treating a seborrheic keratosis in a subject, the method comprising administering a therapeutically effective amount of an ATP-competitive Akt inhibitor to a subject having a seborrheic keratosis.
2. The method of claim 1 , wherein the composition is applied topically or administered systemically.
3. The method of claim 1 , further comprising a step of diagnosing the subject with a seborrheic keratosis.
4. The method of claim 1 , wherein the therapeutically effective amount of the composition does not substantially affect the survival of normal keratinocytes.
5. The method of claim 1 , wherein the composition further comprises a pharmaceutically acceptable carrier.
6. The method of claim 1 , wherein the ATP-competitive Akt inhibitor is selected from the group consisting of: A-443654, AT7867, and GSK690693.