Wound dressings
View Patent ↗A solid wound dressing material comprising: at least about 5 wt % collagen; from about 6 wt % to about 9 wt % polyvinylpyrrolidone triiodide (PVP-I); and from 0 wt % to about 20 wt % water; wherein the weight percentages are based on the dry weight of the composition. Also provided are methods of making such materials, and wound dressings comprising such materials. In another aspect the invention provides a solid wound dressing material comprising: at least about 5 wt % collagen; from about 10 wt % to about 90 wt % Cadexomer iodine; and from 0 wt % to about 20 wt % water, wherein the weight percentages are based on the dry weight of the composition. Also provided are wound dressings comprising the materials.
1. A solid wound dressing material comprising:
at least 5 wt % collagen;
from 6 wt % to 9 wt % polyvinylpyrrolidone triiodide (PVP-I); and
from 0 wt % to 20 wt % water;
wherein the PVP-I and collagen are present in a weight ratio of 0.48:1 to 0.95:1 PVP-I:collagen, and
wherein the weight percentages are based on dry weight.
2. A solid wound dressing material according to claim 1 , comprising:
from 7 wt % to 15 wt. % collagen;
from 6 wt % to 9 wt % polyvinylpyrrolidone triiodide (PVP-I); and
from 0 wt % to 10 wt % water;
wherein the weight percentages are based on dry weight.
3. A solid wound dressing material according to claim 1 , comprising:
from 5 wt % to 15 wt. % collagen;
from 6.3 wt % to 8.5 wt % polyvinylpyrrolidone triiodide (PVP-I); and
from 0 wt % to 10 wt % water;
wherein the weight percentages are based on dry weight.
4. The wound dressing material of claim 1 , further comprising from 5 wt. % to 85 wt. % of one or more plasticisers, based on dry weight.
5. The wound dressing material according to claim 1 , wherein the material is in the form of a plasticized film.
6. The wound dressing material of claim 1 , wherein the PVP-I and collagen are present in a weight ratio of 0.8:1 to 0.95:1 PVP-I:collagen.
7. The wound dressing material of claim 1 , further comprising at least 53 wt. % of one or more plasticisers, based on dry weight.
8. A wound dressing comprising:
a solid wound dressing material, comprising:
at least 5 wt % collagen,
from 6 wt % to 9 wt % polyvinylpyrrolidone triiodide (PVP-I), and
from 0 wt % to 20 wt % water,
wherein the PVP-I and collagen are present in a weight ratio of 0.48:1 to 0.95:1 PVP-I:collagen, and
wherein the weight percentages are based on dry weight; and
a backing layer.
9. A wound dressing according to claim 8 , wherein the wound dressing is sterile and packaged in a microorganism-impermeable container.
10. The wound dressing of claim 8 , wherein the solid wound dressing material further comprises at least 53 wt. % of one or more plasticisers, based on dry weight.
11. A method of making a wound dressing material having PVP-I and collagen present in a weight ratio of 0.48:1 to 0.95:1 PVP-I:collagen, said method comprising:
(a) forming a slurry comprising:
a solvent;
collagen dispersed in said solvent; and
PVP-I dispersed in said solvent; followed by
(b) removing the solvent from the slurry.
12. A method according to claim 11 , wherein said solvent is an aqueous solvent having pH less than 6.
13. The method of claim 11 , wherein the solid wound dressing material further comprises at least 53 wt. % of one or more plasticisers, based on dry weight.