Wound contact layer and dressing for iodine delivery
Disclosed embodiments relate to a wound contact layer in the form of a perforated film, possessing one or more of the following functions: speed of kill, sustained kill, broad-spectrum kill against microorganisms, one-piece removal, conformability with a wound surface, compatibility with negative pressure wound treatment, exudate management, autolytic debridement, and self-indicating of changes. The wound contact layer comprises a biocompatible polymeric matrix and, embedded in the matrix, fluid-absorbent particles loaded with therapeutics. The matrix comprises a mixture of an elastomeric composition and a hydrophilic polymer. The film is perforated with an array of holes. A desired loading of therapeutics in the wound contact layer may be tuned by varying the amount of therapeutics loaded within the fluid-absorbent particles, the density of the fluid-absorbent particles within the wound contact layer, the perforation size, and the thickness of the wound contact layer.
1 . A therapeutic composition, comprising:
a single layer matrix, the matrix comprising:
an elastomeric composition comprising a room temperature vulcanizing silicone; and
a hydrophilic polymer;
a plurality of fluid-absorbent particles embedded in the matrix, individual fluid-absorbent particles configured to swell upon contact with fluid and comprising a crosslinked polymer loaded with an iodine-based antimicrobial agent-powder;
wherein the hydrophilic polymer is configured to form a hydrophilic phase in the matrix, the hydrophilic phase configured to provide a pathway for fluid to travel to the fluid-absorbent particles.
2 . The therapeutic composition of claim 1 , wherein the elastomeric composition comprises between about 10% and about 90% by weight of the composition.
3 . The therapeutic composition of claim 1 , wherein the elastomeric composition comprises one or more silicones.
4 . The therapeutic composition of claim 1 , wherein the elastomeric composition comprises an addition curing room temperature vulcanizing (RTV) silicone made from a mixture of at least one elastomeric composition base and at least one curing agent.
5 . The therapeutic composition of claim 1 , wherein the hydrophilic polymer comprises a polyethylene glycol (PEG).
6 . The therapeutic composition of claim 1 , wherein the PEG comprises an average molecular weight in the range from about 200 to about 1,000 g/mole.
7 . The therapeutic composition of claim 5 , wherein the PEG comprises 20% or less by weight of the composition.
8 . The therapeutic composition of claim 1 , wherein the crosslinked polymer comprises a crosslinked polysaccharide.
9 . The therapeutic composition of claim 1 , wherein the fluid-absorbent particles comprise spherical beads.
10 . The therapeutic composition of claim 1 , wherein the fluid-absorbent particles comprise a diameter of less than 1 mm.
11 . The therapeutic composition of claim 1 , wherein the fluid-absorbent particles comprise between about 30% and about 90% by weight of the composition.
12 . The therapeutic composition of claim 1 , wherein the fluid-absorbent particles comprise preferably between about 50% and about 63% by volume of the composition.
13 . The therapeutic composition of claim 1 , wherein the fluid-absorbent particles comprise cadexomer iodine.
14 . The therapeutic composition of claim 1 , wherein the iodine-based antimicrobial agent comprises less than 2% by weight of the fluid-absorbent particles.
15 . A wound contact layer made from the therapeutic composition of claim 1 .
16 . A wound dressing comprising a layer made from the therapeutic composition of claim 1 .
17 . A multi-care wound contact layer, comprising: a flexible, biocompatible layer having an upper surface and a lower surface defining a thickness there between and an array of holes extending at least partially through the thickness, wherein the flexible, biocompatible layer comprises openings, individual openings adjacent to a plurality of individual internal walls, the layer comprising a single layer matrix, the matrix comprising: a room temperature vulcanizing silicone elastomeric composition and a hydrophilic polymer, wherein the hydrophilic polymer is configured to form a hydrophilic phase in the matrix, the hydrophilic phase configured to provide a pathway for fluid to travel to the fluid-absorbent particles; and a plurality of fluid-absorbent particles embedded in the matrix that are configured to swell upon contact with fluid, individual fluid-absorbent particles comprising a crosslinked polymer loaded with an iodine-based antimicrobial agent powder.
18 . The multi-care wound contact layer of claim 17 , wherein the hydrophilic polymer comprises polyethylene glycol (PEG).
19 . The multi-care wound contact layer of claim 17 , wherein the flexible, biocompatible layer comprises, by weight:
10-90% elastomeric composition;
1-20% hydrophilic polymer; and
30-90% fluid-absorbent particles.
20 . The multi-care wound contact layer of claim 17 , wherein the iodine-based antimicrobial agent comprises less than 2% by weight of the fluid-absorbent particles.