Pyridine CGRP receptor antagonists
View Patent ↗The present invention is directed to pyridine derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
1. A compound which is:
(6S)—N-[(5S,6S,9R)-5-Amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl]-2′-oxo-1′,2′,5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3′-pyrrolo[2,3-b]pyridine]-3-carboxamide;
(6S)—N-[(5S,6S,9S)-5-Amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl]-2′-oxo-1′,2′,5,7-tetrahydrospiro [cyclopenta[b]pyridine-6,3′-pyrrolo [2,3 -b]pyridine]-3 -carboxamide;
(6S)—N-[(5R,6S,9R)-5-Amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta [b]pyridin-9-yl]-2′-oxo-1′,2′,5,7-tetrahydrospiro [cyclopenta[b]pyridine-6,3′-pyrrolo [2,3 -b]pyridine]-3-carboxamide; or
(6S)—N-[(5R,6S,9S)—-5-Amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl]-2′-oxo-1′,2′,5,7-tetrahydro spiro [cyclopenta[b]pyridine-6,3′-pyrrolo [2,3 -b]pyridine]-3-carboxamide;
or a pharmaceutically acceptable salt of any thereof.
2. A compound of the Formula:
wherein, R A is —NH 2 , —F, or —H, and R B are both -F or both —H.
3. A pharmaceutical composition comprising a compound of claim 2 , or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.
4. A method of treating Migraine by providing an effective amount of a pharmaceutical formulation of claim 3 to a patient in need thereof.