IP Library Granted Patent US 10,045,752
Granted Patent B2
US 10,045,752 · App. 14/400,703 · Granted Aug 14, 2018

Method for coded-source phase contrast X-ray imaging

Inventors: Rajiv Gupta (Wayland, MA); Luis Fernando Velasquez-Garcia (Cambridge, MA); Richard Lanza (Cambridge, MA); Berthold K P Horn (Boston, MA); Akintunde Ibitayo Akinwande (Cambridge, MA)
Assignees: The General Hospital Corporation; Massachusetts Institute of Technology
A61B6/484A61B6/40A61B6/405A61B6/4007A61B6/4405G01N23/04G01V5/0016G01V5/0041H01J35/065H01J35/12G21K2207/005H01J2201/30449H01J2235/062H01J2235/068H01J2235/087H01J2235/186
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Quick Facts
Patent No.
US 10,045,752
App. No.
14/400,703
Granted
Aug 14, 2018
Kind
B2
Abstract

Described here is a method for performing phase contrast imaging using an array of independently controllable x-ray sources. The array of x-ray sources can be controlled to produce a distinct spatial pattern of x-ray radiation and thus can be used to encode phase contrast signals without the need for a coded aperture. The lack of coded aperture increases the flexibility of the imaging method. For instance, because a fixed, coded aperture is not required, the angular resolution of the imaging technique can be increased as compared to coded-aperture imaging. Moreover, the lack of a radioopaque coded aperture increases the photon flux that reaches the subject, thereby increasing the attainable signal-to-noise ratio.

Claims (13)

1. A method for phase contrast imaging using an array of independently controllable x-ray sources, the steps of the method comprising:

a) directing an array of independently controllable x-ray sources to produce x-ray radiation in a distinct spatial pattern by selectively energizing the independently controllable x-ray sources in the array;

b) detecting phase-contrast signals of the x-ray radiation after the x-ray radiation passes through a subject using an x-ray detector; and

c) reconstructing an image of the subject by performing a compressed sensing reconstruction technique on the detected phase-contrast signals, wherein the reconstructed image depicts an image contrast indicative of phase shifts in the x-ray radiation.

2. The method as recited in claim 1 , in which each x-ray source of the array of independently controllable x-ray sources has a focal spot sized less than twenty micrometers.

3. The method as recited in claim 1 , in which the x-ray detector is separated from the subject by at least one meter.

4. The method as recited in claim 1 , in which the x-ray detector has an effective detector pitch of less than ten micrometers.

5. The method as recited in claim 1 , in which the distinct spatial pattern is selected as at least one of a uniformly redundant array (URA) and a modified uniformly redundant array (MURA).

6. The method as recited in claim 1 , in which step c) includes determining a target image, X, that minimizes an objective function defined as, ∥ΨX∥ 1 ; wherein Ψ is a sparsifying transform that transforms the target image, X, into a sparse domain.

7. The method as recited in claim 6 , in which the sparsifying transform is a discrete gradient transform.

8. The method as recited in claim 1 , in which the subject is at least one of a human and an animal.

9. The method as recited in claim 1 , in which the subject is at least one of a piece of luggage and a cargo container.

10. The method as recited in claim 9 , in which the at least one of a piece of luggage and a cargo container includes an explosive, and the method further comprises identifying the explosive by analyzing the image reconstructed in step c).

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 5, 2016
From: GUPTA, RAJIV
To: THE GENERAL HOSPITAL CORPORATION
Reel/Frame 037406/0486 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 5, 2016
From: VELASQUEZ-GARCIA, LUIS FERNANDO; LANZA, RICHARD; HORN, BERTHOLD KP; AKINWANDE, AKINTUNDE IBITAYO
To: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Reel/Frame 037406/0568 →
Continuity (2)
Provisional Application 61646577 · May 14, 2012
Related Publication 20150146848A1 · May 28, 2015