IP Library › Granted Patent US 12,156,912
Granted Patent B2
US 12,156,912 · App. 14/401,428 · Granted Dec 3, 2024

Methods and compositions for inhibiting diseases of the central nervous system

Inventors: Howard E. Gendelman (Omaha, NE); R. Lee Mosley (Omaha, NE)
Assignee: Board of Regents of the University of Nebraska
A61K39/39A61K38/1709A61K38/193A61K38/2278A61K39/0005A61K2039/555
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,156,912
App. No.
14/401,428
Granted
Dec 3, 2024
Kind
B2
Abstract

Methods and compositions for treating central nervous system diseases and disorders are disclosed. In a particular embodiment, compositions comprising a nitrated alpha synuclein peptide are provided. The composition may further comprise an adjuvant that stimulates regulatory T cells and/or at least one pharmaceutically acceptable carrier.

Claims (2)

1. A composition comprising: a) an alpha-synuclein peptide, wherein said alpha-synuclein peptide consists of SEQ ID NO: 11, wherein said alpha-synuclein peptide is amidated or acetylated, and wherein said alpha-synuclein peptide comprises at least one nitrotyrosine; and b) a pharmaceutically acceptable carrier.

2. A composition comprising: a) an alpha-synuclein peptide, wherein said alpha-synuclein peptide consists of SEQ ID NO: 3, wherein said alpha-synuclein peptide is amidated or acetylated, and wherein said alpha-synuclein peptide comprises at least one nitrotyrosine; and b) a pharmaceutically acceptable carrier.

Assignments (2)
CONFIRMATORY LICENSE Recorded Dec 29, 2014
From: UNIVERSITY OF NEBRASKA MEDICAL CENTER
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 034709/0593 →
CONFIRMATORY LICENSE Recorded Dec 1, 2014
From: UNIVERSITY OF NEBRASKA MEDICAL CENTER
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 034498/0744 →
Continuity (2)
Provisional Application 61649056 · May 18, 2012
Related Publication 20150139937A1 · May 21, 2015