Macrocycles
The invention provides macrocycles useful in chelating metal ions, particularly radionuclides, to provide metal ion complexes. The invention also provides methods of using the compounds and complexes of the invention, such as in therapeutic and diagnostic applications.
1. A macrocycle having the structure:
wherein A p1 and A p2 are independently selected from
wherein R s comprises a solubilizing group; and
R 11 is methyl or ethyl; and
each n is an integer independently selected from 2 and 3.
2. The macrocycle according to claim 1 , wherein A p1 and A p2 are each
3. The macrocycle according to claim 2 , having a structure selected from
4. A complex comprising a macrocycle according to any one of the preceding claims and a metal ion.
5. The complex according to claim 4 , wherein said metal is a radionuclide.
6. The complex according to claim 5 , wherein said radionuclide is Thorium (Th).
7. The complex according to claim 5 , wherein said radionuclide is Cerium (Ce).