Granted Patent
B2
US 9,730,941 · App. 14/406,401 · Granted Aug 15, 2017
Methods and compositions for the inhibition of Pin1
Inventors:
Kun Ping Lu (Newton, MA); Matthew Brian Boxer (Rockville, MD); Mindy Irene Emily Davis (Rockville, MD); Rajan Pragani (Rockville, MD); Min Shen (Rockville, MD); Anton Momtchilov Simeonov (Rockville, MD); Shuo Wei (Chestnut Hill, MA); Xiao Zhen Zhou (Newton, MA)
Assignees:
Beth Israel Deaconess Medical Center, Inc.; The United States of America as represented by the Secretary, Department of Health and Human Services
A61K31/5377A61K31/185A61K31/341A61K31/357A61K31/365A61K31/381A61K31/382A61K31/402A61K31/404A61K31/405A61K31/4025A61K31/427A61K31/428A61K31/4245A61K31/473A61K31/4704A61K31/496A61K45/06
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Abstract
The invention features compositions and methods for inhibiting the Pin1 protein, and the treatment of disorders characterized by elevated Pin1 levels.
Claims (4)
1. A method of inhibiting Pin1 by contacting Pin1 with a compound having the structure selected from Compound 48 and Compound 49:
wherein said compound is a Pin1 inhibitor.
2. The method of claim 1 , wherein said Pin1 is in a cell.
3. The method of claim 2 , wherein said cell is a human cell.
Assignments (3)
CONFIRMATORY LICENSE
Recorded Jun 17, 2016
From: BETH ISRAEL DEACONESS MEDICAL CENTER
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 039072/0081 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Apr 6, 2015
From: LU, KUN PING; WEI, SHUO; ZHOU, XIAO ZHEN
To: BETH ISRAEL DEACONESS MEDICAL CENTER, INC.
Reel/Frame 035341/0479 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Apr 6, 2015
From: BOXER, MATTHEW BRIAN; DAVIS, MINDY IRENE EMILY; PRAGANI, RAJAN; SHEN, MIN; SIMEONOV, ANTON MOMTCHILOV
To: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
Reel/Frame 035341/0541 →
Continuity (2)
Provisional Application
61656806
· Jun 7, 2012