IP Library › Granted Patent US 10,286,064
Granted Patent B2
US 10,286,064 · App. 14/407,419 · Granted May 14, 2019

Cationic lipid vaccine compositions and methods of use

Inventors: Kenya Johnson (Mason, OH); Eric Jacobson (Cincinnati, OH); Frank Bedu-Addo (Bethel, CT); Mikayel Mkrtichyan (Rockville, MD); Samir N. Khleif (Silver Spring, MD)
Assignees: PDS Biotechnology Corporation; THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SEC. OF THE DEPT. OF HEALTH AND HUMAN SERVICES
A61K39/39A61K39/0005A61K39/0011A61K39/12A61K2039/55511A61K2039/55516A61K2039/55522A61K2039/55555A61K2039/55566A61K2039/585C12N2710/20034
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Quick Facts
Patent No.
US 10,286,064
App. No.
14/407,419
Granted
May 14, 2019
Kind
B2
Abstract

The present disclosure provides vaccine compositions comprising at least one adjuvant and at least one therapeutic factor. The disclosure also provides methods of reducing an immune suppressor cell population in a mammal, methods of augmenting an immune response in a mammal, and methods of treating a disease in a mammal utilizing the vaccine compositions.

Claims (3)

1. A composition consisting essentially of a cationic lipid and GM-CSF, wherein the cationic lipid consists of DOTAP, wherein the composition is in a dosage sufficient to reduce a myeloid-derived suppressor cell population in a tumor microenvironment of a subject.

2. The composition of claim 1 , wherein the cationic lipid is an enantiomer of the cationic lipid.

3. The composition of claim 2 , wherein the enantiomer is R-DOTAP.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 27, 2016
From: JOHNSON, KENYA; BEDU-ADDO, FRANK
To: PDS BIOTECHNOLOGY CORPORATION
Reel/Frame 037597/0835 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 27, 2016
From: JACOBSON, ERIC
To: PDS BIOTECHNOLOGY CORPORATION
Reel/Frame 037597/0890 →
Continuity (2)
Provisional Application 61660172 · Jun 15, 2012
Related Publication 20150132340A1 · May 14, 2015
Cited By (2)
US 12,201,685 US 12,551,460