Microbicidal composite material
A composite material having inherent microbicidal activity is herewith described. The microbicidal composite material comprises of a first layer having a first predefined thickness and a first predefined stitch/thread density; a second layer having a second predefined thickness and a second predefined stitch/thread density; an intermediate layer having a third predefined thickness and a third predefined stitch/thread density, wherein the intermediate layer is sandwiched between the first layer and the second layer, and where the intermediate layer is connected to the first layer and the second layer to form a three dimensional structure, and where each layer in the three dimensional structure has a plurality of apertures. Further, at least one layer in the three dimensional structure comprises at least one of microfibers and nanofibers having augmented surface moieties, wherein the augmented surface moieties allow for binding of a microbicidal agent to impart the inherent microbicidal activity.
1. A microbicidal composite material comprising:
a first layer having a first pre-defined thickness and a first predefined stitch/thread density;
a second layer having a second pre-defined thickness and a second predefined stitch/thread density; and
an intermediate layer having a third pre-defined thickness and a third predefined stitch/thread density wherein the intermediate layer is sandwiched between and connected to the first layer and the second layer to form a three dimensional structure by one of knitting and weaving, wherein each layer in the three dimensional structure has plurality of apertures to allow for circulation of air through the microbicidal composite material;
wherein each of the plurality of apertures is associated with a pre-determined size and wherein the pre-determined size of the apertures is controlled by course per inch and wales per inch of the one of knitting and weaving process;
wherein the third pre-defined stitch/thread density is less than the first pre-defined stitch/thread density and the second pre-defined stitch/thread density, to allow for wicking of a fluid on contact of at least one of the first layer and the second layer with the fluid; and
wherein each layer of the three-dimensional structure comprises surface moieties cross linked to a microbicidal agent in a non-eluting manner.
2. The microbicidal composite material of claim 1 , wherein the first pre-defined thickness is in the range of 100 micron to 1000 micron.
3. The microbicidal composite material of claim 1 , wherein the second pre-defined thickness is in the range of 100 micron to 1000 micron.
4. The microbicidal composite material of claim 1 , wherein the third pre-defined thickness is in the range of 600 micron to 6000 micron.
5. The microbicidal composite material of claim 1 , wherein the fluid is a bio fluid.
6. The microbicidal composite material of claim 1 , wherein each layer in the three dimensional structure is permeable to fluids and gases.
7. The microbicidal composite material of claim 1 , wherein each layer in the three dimensional structure comprises at least one material selected from a group consisting of natural fibers, synthetic fibers, and regenerated fibers selected from the group consisting of polyester, acrylic, polyamide, polyurethane, regenerated cellulose, poly acylonitriles, polytriphenylene terephthalate, polybutylene terephthalate, polylactic acid, aramides, metaramides, nylon6, nylon 6.6, polypropylene, polyethylene, poly-p-phenyleneteraphthalamid, poly-m-phenyleneteraphthalamide, natural rubber, wool, cotton, flax, rayon, jute, and linen.
8. The microbicidal composite material of claim 7 , wherein at least one layer in the three dimensional structure is composed of an elastomeric material selected from the group consisting of textured yarns/fibers, multi component yarns/fibers, polyurethane and natural rubber to impart resilient property.
9. The microbicidal composite material of claim 1 , wherein the microbicidal agent cross linked to surface moieties is a compound of Formula I
wherein:
R 1 is independently selected from hydrogen or C 1 to C 4 alkyl;
R 2 is a divalent hydrocarbon radical with C 1 to C 8 carbon atoms;
R 3 is independently selected from hydrogen or C 1 to C 4 alkyl;
R 4 is independently selected from hydrogen or C 1 to C 10 alkyl;
R 5 is a C 8 to C 22 saturated or unsaturated hydrocarbon radical; and
X is counter anion selected from the group consisting of Cl − , Br − , I − , OH − , HCO 3 − , CO 3 2− .
10. The microbicidal composite material of claim 9 , wherein the microbicidal agent is one selected from the group consisting of 3-(trimethoxysilyl)propyl-N-octadecyl-N,N-dimethyl ammonium chloride, 3-(trimethoxysilyl)propyl-N-tetradecyl-N,N-dimethyl ammonium chloride, 3-(trimethoxysilyl) propyl-N,N-didecyl-N-methyl ammonium chloride, and 3-(trihydroxysilyl) propyl-N-octadecyl-N,N-dimethyl ammonium chloride.
11. The microbicidal composite material of claim 1 , wherein the microbial composite material is used in whole or part of wound dressing.
12. The microbicidal composite material of claim 1 , wherein the microbial composite material is used to treat a wound caused by one or more of a gram positive bacteria, gram negative bacteria, virus and fungi, or a combination thereof.
13. The microbicidal composite material of claim 1 , wherein the microbial composite material is used as a filter for sterilizing at least one of fluid of air, water, and milk, or a combination thereof.
14. The microbicidal composite material of claim 1 , wherein the microbial composite material is for use in whole or part of, one or more of a sanitary pad, tampons, toilet accessories, diaper, sanitary wipe, surgical gown, surgical glove, surgical scrub, mattress covers, beddings, bedding sheets and pillow covers, operation theatre covers, hospital examination table covers, hospital bio waste disposable bags, hospital curtains, air conditioning filters, face mask, meat storage, and packing materials.
15. The microbicidal composite material of claim 1 , wherein each layer in the three dimensional structure comprises at least one of a microfiber and a nanofiber for augmentation of available surface moieties, wherein the augmented surface moieties allow for a greater concentration of the bound microbicidal agent as compared to a surface without the surface augmentation.
16. The microbicidal composite material of claim 1 , wherein the knitting is spacer knitting and the weaving is spacer weaving.
17. A wound dressing comprising the microbicidal composite material of claim 1 , in part or in whole.
18. The wound dressing of claim 17 , wherein the first pre-defined thickness is in the range of 100 micron to 1000 micron.
19. The wound dressing of claim 17 , wherein the second pre-defined thickness is in the range of 100 micron to 1000 micron.
20. The wound dressing of claim 17 , wherein the third pre-defined thickness is in the range of 600 micron to 6000 micron.
21. The wound dressing of claim 17 , wherein each layer in the three dimensional structure is selectively permeable to body fluids and gases from the wound.
22. The wound dressing of claim 17 ,
wherein each layer in the three dimensional structure is composed of at least one material selected from the group consisting of natural fibers, synthetic fibers, regenerated fibers, and a combination thereof,
wherein the regenerated fibers are selected from the group consisting of polyester, acrylic, polyamide, polyurethane, regenerated cellulose, poly acylonitriles, textured polyethylene terephthalate, polytriphenylene terephthalate, polybutylene terephthalate, polylactic acid, aramides, metaramides, nylon6, nylon 6.6, polypropylene, polyethylene, poly-p-phenyleneteraphthalamid, poly-m-phenyleneteraphthalamide, natural rubber, wool, cotton, flax, rayon, jute and linen, and a combination thereof.
23. The wound dressing of claim 17 , wherein at least one layer in the three dimensional structure is composed of a biopolymer, and wherein the biopolymer includes at least one material selected from the group consisting of poly lactic acid, poly glycolic acid, and caprolactum.
24. The wound dressing of claim 23 , wherein at least one layer in the three dimensional structure comprises bioactive agents to impart sustained and time release of the bioactive agents, and wherein the bioactive agents include at least one bioactive agent selected from the group consisting of vitamins, minerals, anti inflammatory agents, antibiotics, antiseptic, haemostatic agents and analgesics.
25. The wound dressing of claim 17 , wherein at least one layer in the three dimensional structure comprises an elastomeric material, and wherein the elastomeric material is selected from the group consisting of a textured yarns/fibers, multi component yarns/fibers, polyurethane and natural rubber to impart resilient property.
26. The wound dressing of claim 17 , wherein the microbicidal agent cross linked to the augmented surface moieties is a compound of Formula I
wherein:
R 1 =hydrogen and/or C 1 to C 4 alkyl;
R 2 =divalent hydrocarbon radical with C 1 to C 8 carbon atoms;
R 3 =hydrogen or C 1 to C 4 alkyl;
R 4 =hydrogen or C 1 to C 10 alkyl;
R 5 =C 8 to C 22 saturated or unsaturated hydrocarbon radical; and
X=alkyl halide.
27. The wound dressing material of claim 26 , wherein the microbicidal agent is one selected from the group consisting of 3-(trimethoxysilyl)propyl-N-octadecyl-N, N-dimethyl ammonium chloride, 3-(trimethoxysilyl)propyl-N-tetradecyl-N,N-dimethyl ammonium chloride, 3-(trimethoxysilyl) propyl-N,N-didecyl-N-methyl ammonium chloride, and 3-(trihydroxysilyl) propyl-N-octadecyl-N,N-dimethyl ammonium chloride.
28. The wound dressing of claim 17 , wherein each layer in the three dimensional structure comprises at least one of a microfiber and a nanofiber for augmentation of available surface moieties, wherein the augmented surface moieties allow for a greater concentration of the bound microbicidal agent.
29. The wound dressing of claim 17 , wherein the knitting is spacer knitting and the weaving is spacer weaving.