Compositions, methods and/or devices for prevention and/or treatment of dry eye disorders
The present disclosure relates to compositions, methods and devices for treating, reducing or preventing one or more eye disorders, particularly dry eye disorders, in a subject by administering an amount of one or more fatty acids and/or fatty acid esters therapeutically effective to inhibit lipase activity while permitting bacterial growth or without substantially altering the dynamic microbial community of the eye. Typically, the fatty acids and/or fatty acid esters are C 8 to C 16 fatty acids and/or fatty acid esters.
1. A method for treating a dry eye disorder in a subject by administering to the subject's eye a composition with an amount of lauric acid or a combination of lauric acid and glycerol monolaurate therapeutically effective to inhibit lipase activity by about 35% to 75% without substantially altering the dynamic microbial community of the subject's eye to which the composition has been administered;
wherein the amount of lauric acid or a combination of lauric acid and glycerol monolaurate is in a concentration of between 2.5 μg/ml to 15 μg/ml in the composition.
2. A method according to claim 1 , wherein the topical administration is in the form of an ointment, cream, eye drops or released from an ophthalmic device.
3. The method of claim 2 , wherein the composition is released from the ophthalmic device and the ophthalmic device is a contact lens.
4. The method of claim 2 , wherein the concentration of lauric acid or a combination of lauric acid and glycerol monolaurate is 2.5 μg/ml to 15 μg/ml in the eye drops administered to the eye.
5. The method of claim 2 , wherein the concentration of lauric acid or a combination of lauric acid and glycerol monolaurate is 2.5 μg/ml to 15 μg/ml in a composition associated with a contact lens.
6. The method according to claim 1 , wherein the amount of lauric acid or a combination of lauric acid and glycerol monolaurate is therapeutically effective to inhibit lipase activity in the subject's eye while permitting bacterial growth in the subject's eye.