Modulation of the immune response
Described herein are compositions and methods for the modulation of T-cell tolerance, which can be upregulated or down regulated by concurrent enhancement or inhibition of CEACAM1/TIM3 interactions. As described herein, the discovery that CEACAM1 is a direct ligand of TIM3 and vice versa has been shown in cis and in trans. In addition, as demonstrated herein, CEACAM1 and TIM3 are co-regulated during the course of T-cell activation.
1. A composition comprising a proteo-mimetic agent comprising SEQ ID NO: 31.
2. The composition of claim 1 , wherein the proteo-mimetic agent is fused to a heterologous polypeptide, or portion thereof.
3. The composition of claim 2 , wherein the heterologous polypeptide is selected from the group consisting of transferrin, serum albumin, or an immunoglobulin heavy chain constant region (Fc).
4. The composition of claim 1 , wherein the proteo-mimetic agent is conjugated to a polymer.
5. The composition of claim 4 , wherein the polymer is polyethylene glycol (PEG).
6. A composition comprising a fusion polypeptide comprising
(a) a proteo-mimetic agent consisting of SEQ ID NO: 30; and
(b) a heterologous polypeptide, or portion thereof.
7. The composition of claim 6 , wherein the heterologous polypeptide is selected from the group consisting of transferrin, serum albumin, or an immunoglobulin heavy chain constant region (Fc).
8. A composition comprising a conjugate molecule comprising
(a) a proteo-mimetic agent consisting of SEQ ID NO: 30; and
(b) a polymer, wherein the polymer is polyethylene glycol (PEG).