Methods and Compositions For Treating Hepatocellular Carcinoma

1 . A method of treating a subject having a tumor comprising administering an effective amount of the prodrug G-202 to said subject.

2 . The method of claim 1 , wherein said effective amount of said prodrug is administered for at least one day of a 28-day cycle.

3 . The method of claim 2 , wherein said effective amount of said prodrug comprises administering at least about 40 mg/m 2 of said prodrug.

4 . The method of claim 3 , wherein said effective amount of said prodrug comprises administering at least about 60 mg/m 2 of said prodrug.

5 . The method of claim 4 , wherein said effective amount of said prodrug comprises administering at least about 80 mg/m 2 of said prodrug.

6 . The method of claim 2 , wherein said effective amount of said prodrug is administered for at least two consecutive days.

7 . The method of claim 6 , wherein said at least two consecutive days occurs at the beginning of a 28-day cycle.

8 . The method of claim 7 , wherein said effective amount of said prodrug comprises administering about 40 mg/m 2 of said prodrug on day 1, and about 66.8 mg/m 2 of said prodrug on day 2.

9 . The method of claim 7 , wherein said effective amount of said prodrug comprises administering about 40 mg/m 2 of said prodrug on days 1 and 2.

10 . The method of claim 6 , wherein said effective amount of said prodrug is administered for at least three consecutive days.

11 . The method of claim 10 , wherein said at least three consecutive days occurs at the beginning of a 28-day cycle.

12 . The method of claim 11 , wherein said effective amount of said prodrug comprises administering about 40 mg/m 2 of said prodrug on day 1, and about 66.8 mg/m 2 of said prodrug on each of days 2 and 3.

13 . The method of claim 11 , wherein said effective amount of said prodrug comprises administering about 40 mg/m 2 of said prodrug on days 1, 2 and 3.

14 . The method of claim 1 , wherein said tumor is selected from the group consisting of prostate cancer, hepatocellular carcinoma and glioblastoma.

15 . The method of claim 2 , wherein said 28-day cycle is repeated at least once.

16 . The method of claim 2 , wherein administration is selected from the group consisting of intravenous, intramuscular, subcutaneous, implantable pump, continuous infusion, liposomal and oral administration.

17 . The method of claim 16 , wherein said prodrug is administered via infusion.

18 . The method of claim 16 , wherein said prodrug is administered via injection.

19 . The method of claim 16 , wherein said prodrug is administered in combination with chemotherapy, surgery, other procedure, other anti-cancer agent(s) or other therapeutic methods.

20 . The method of claim 19 , wherein said prodrug is administered prior to surgery.

21 . The method of claim 20 , wherein said prodrug is administered for at least two 28-day cycles.

22 . A method of preventing the spread of, stabilizing or reducing a tumor comprising administering and effective amount of the prodrug G-202 to a subject having a tumor.

23 . The method of claim 22 , wherein said effective amount of said prodrug is administered for at least one day of a 28-day cycle.

24 . The method of claim 23 , wherein said effective amount of said prodrug comprises administering at least about 40 mg/m 2 of said prodrug.

25 . The method of claim 24 , wherein said effective amount of said prodrug comprises administering at least about 60 mg/m 2 of said prodrug.

26 . The method of claim 25 , wherein said effective amount of said prodrug comprises administering at least about 80 mg/m 2 of said prodrug.

27 . The method of claim 22 , wherein said effective amount of said prodrug is administered for at least two consecutive days.

28 . The method of claim 27 , wherein said at least two consecutive days occurs at the beginning of a 28-day cycle.

29 . The method of claim 28 , wherein said effective amount of said prodrug comprises administering about 40 mg/m 2 of said prodrug on day 1, and about 66.8 mg/m 2 of said prodrug on day 2.

30 . The method of claim 28 , wherein said effective amount of said prodrug comprises administering about 40 mg/m 2 of said prodrug on days 1 and 2.

31 . The method of claim 27 , wherein said effective of said prodrug amount is administered for at least three consecutive days.

32 . The method of claim 31 , wherein said at least three consecutive days occurs at the beginning of a 28-day cycle.

33 . The method of claim 32 , wherein said effective amount of said prodrug comprises administering about 40 mg/m 2 of said prodrug on day 1, and about 66.8 mg/m 2 of said prodrug on each of days 2 and 3.

34 . The method of claim 32 , wherein said effective amount of said prodrug comprises administering about 40 mg/m 2 of said prodrug on days 1, 2 and 3.

35 . The method of claim 22 , wherein said tumor is selected from the group consisting of prostate cancer, hepatocellular carcinoma and glioblastoma.

36 . The method of claim 23 , wherein said 28-day cycle is repeated at least once.

37 . The method of claim 23 , wherein administration is selected from the group consisting of intravenous, intramuscular, subcutaneous, implantable pump, continuous infusion, liposomal and oral administration.

38 . The method of claim 37 , wherein said prodrug is administered via infusion.

39 . The method of claim 37 , wherein said prodrug is administered via injection.

40 . The method of claim 37 , wherein said prodrug is administered in combination with chemotherapy, surgery, other procedure, other anti-cancer agent(s) or other therapeutic methods.

41 . The method of claim 40 , wherein said prodrug is administered prior to surgery.

42 . The method of claim 41 , wherein said prodrug is administered for at least two 28-day cycles.

43 . A method for treating prostate cancer, hepatocellular carcinoma or glioblastoma in a patient comprising administering an effective amount of the prodrug G-202 to said patient.

44 . The method of claim 43 , wherein said effective amount of said prodrug is administered for at least one day of a 28-day cycle.

45 . The method of claim 44 , wherein said effective amount of said prodrug comprises administering at least about 40 mg/m 2 of said prodrug.

46 . The method of claim 45 , wherein said effective amount of said prodrug comprises administering at least 60 about mg/m 2 of said prodrug.

47 . The method of claim 46 , wherein said effective amount of said prodrug comprises administering at least 80 about mg/m 2 of said prodrug.

48 . The method of claim 44 , wherein said effective amount of said prodrug is administered for at least two consecutive days.

49 . The method of claim 48 , wherein said at least two consecutive days occurs at the beginning of a 28-day cycle.

50 . The method of claim 49 , wherein said effective amount of said prodrug comprises administering about 40 mg/m 2 of said prodrug on day 1, and about 66.8 mg/m 2 of said prodrug on day 2.

51 . The method of claim 49 , wherein said effective amount of said prodrug comprises administering about 40 mg/m 2 of said prodrug on days 1 and 2.

52 . The method of claim 44 , wherein said effective amount of said prodrug is administered for at least three consecutive days.

53 . The method of claim 52 , wherein said at least three consecutive days occurs at the beginning of a 28-day cycle.

54 . The method of claim 53 , wherein said effective amount of said prodrug comprises administering about 40 mg/m 2 of said prodrug on day 1, and about 66.8 mg/m 2 of said prodrug on each of days 2 and 3.

55 . The method of claim 53 , wherein said effective amount of said prodrug comprises administering about 40 mg/m 2 of said prodrug on days 1, 2 and 3.

56 . The method of claim 44 , wherein said 28-day cycle is repeated at least once.

57 . The method of claim 44 , wherein administration is selected from the group consisting of intravenous, intramuscular, subcutaneous, implantable pump, continuous infusion, liposomal and oral administration.

58 . The method of claim 57 , wherein said prodrug is administered via infusion.

59 . The method of claim 57 , wherein said prodrug is administered via injection.

60 . The method of claim 57 , wherein said prodrug is administered in combination with chemotherapy, surgery, other procedure, other anti-cancer agent(s) or other therapeutic methods.

61 . The method of claim 60 , wherein said prodrug is administered prior to surgery.

62 . The method of claim 61 , wherein said prodrug is administered for at least two 28-day cycles.

63 . A kit comprising an effective amount of G-202.

64 . The kit of claim 63 wherein G-202 is lyophilized.