IP Library › Granted Patent US 9,545,393
Granted Patent B2
US 9,545,393 · App. 14/423,674 · Granted Jan 17, 2017

Methods and compositions for treating pain

Inventors: Vanessa Zambelli (Sao Paulo, BR); Che-Hong Chen (Fremont, CA); Daria Mochly-Rosen (Menlo Park, CA)
Assignee: The Board of Trustees of the Leland Stanford Junior University
A61K31/36A01K67/0278A61K31/357C12N9/0008C12N15/8509C12Y102/01003A01K2217/077A01K2227/105A01K2267/0356
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Quick Facts
Patent No.
US 9,545,393
App. No.
14/423,674
Granted
Jan 17, 2017
Kind
B2
Abstract

Methods and compositions are provided for treating pain in an individual. Aspects of the methods include administering to the individual an agent that promotes ALDH activity. These methods find many uses, for example in treating and preventing nociceptive pain, inflammatory pain, and neuropathic pain.

Claims (11)

1. A method of treating hyperalgesia in an individual, comprising:

administering to the individual an effective amount of an ALDH2 agonist, wherein the ALDH2 agonist is Alda-1 or ALDA-44.

2. The method according to claim 1 , wherein the ALDH2 agonist is administered after the onset of pain.

3. The method according to claim 1 , wherein the individual is a human.

4. The method according to claim 3 , wherein the individual has a hypomorphic mutation in ALDH2.

5. The method according to claim 4 , wherein the mutation is ALDH2*2.

6. A method of decreasing hyperalgesia in an individual, comprising:

administering to the individual an effective amount of an ALDH2 agonist, wherein the ALDH2 agonist is Alda-1 or ALDA-44.

7. The method according to claim 6 , wherein the ALDH2 agonist is administered prior to the onset of pain.

8. The method according to claim 6 , wherein the individual has a hypomorphic mutation in ALDH2.

9. The method according to claim 8 , wherein the mutation is ALDH2*2.

Assignments (2)
CONFIRMATORY LICENSE Recorded Jul 7, 2015
From: STANFORD UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 036073/0980 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 3, 2015
From: ZAMBELLI, VANESSA; CHEN, CHE-HONG; MOCHLY-ROSEN, DARIA
To: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
Reel/Frame 035778/0448 →
Continuity (2)
Provisional Application 61693188 · Aug 24, 2012
Related Publication 20150182495A1 · Jul 2, 2015