No-releasing polymers and uses thereof
The present invention provides stable, photosensitive polymers that release NO response to intensity and wavelength of light, methods of making such polymers and methods using such polymers.
1. A compound of Formula (II):
and racemates, enantiomers and diastereomers thereof;
wherein:
R* is a polysiloxane;
each R 3 is independently selected from H and aminocarbonyl, at least one R 3 is an aminocarbonyl;
each R 4 is independently selected from C 1-4 alkyl;
each R 5 is H;
and
n is 1 to 6.
2. The compound according to claim 1 , wherein n is 3.
3. The compound according to claim 1 , wherein one R 3 is —NHC(O)CH 3 .
4. The compound according to claim 3 , wherein the other R 3 is H.
5. The compound according to claim 1 , wherein both R 4 are methyl.
6. A medical device comprising a composition comprising the compound according to claim 1 .
7. The medical device of claim 6 , wherein at least a portion of the medical device is fabricated from the composition.
8. The medical device of claim 7 , wherein the portion defines an outer surface of the medical device.
9. The medical device of claim 8 , wherein the medical device is coated with the composition.
10. A method for improving the biocompatibility of a medical device, comprising, coating the medical device with a composition comprising the compound according to claim 1 .