IP Library Granted Patent US 9,919,140
Granted Patent B2
US 9,919,140 · App. 14/433,583 · Granted Mar 20, 2018

Implantable oxygenator with self-contained electrolyte

Inventors: Mark S. Humayun (Glendale, CA); Karthik Murali (Los Angeles, CA); Ramiro Magalhaes Ribeiro (South Pasadena, CA); Yu-chong Tai (Pasadena, CA); Nicholas Scianmarello (Pasadena, CA)
Assignee: University of Southern California
A61M37/00A61F9/0017A61M5/14276C25B1/02C25B9/08A61M2005/14204A61M2205/3334A61M2210/0612
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Quick Facts
Patent No.
US 9,919,140
App. No.
14/433,583
Granted
Mar 20, 2018
Kind
B2
Abstract

An implantable oxygenator may have a configuration that is suitable for implantation within a human body be implanted within a human body, such as within a human eye. The implantable oxygenator may include an electrolyte reservoir having a configuration suitable for storing electrolyte and an electrolysis system having a configuration that performs electrolysis on a portion of the electrolyte, thereby producing oxygen in the region of the electrolysis system.

Claims (22)

1. An oxygenator implanted within a human body, the human body having an eye that includes a pupil, a sclera surrounding a volume of the eye, and a macula, the oxygenator comprising: an electrolyte reservoir containing electrolyte, the electrolyte reservoir being within the human body and outside of the volume of the eye surrounded by the sclera; an electrolysis system that is separate from and not part of the electrolyte reservoir having an electrolysis bag containing electrodes and that performs electrolysis on electrolyte, thereby producing oxygen in the region of the electrolysis bag, the electrolysis bag being within the volume surrounded by the sclera and straddling the macula, but not substantially within the pathway of light traveling though the pupil to the; and a cannula that delivers electrolyte from the electrolyte reservoir to the electrolysis system.

2. The implantable oxygenator of claim 1 further comprising an internal control system having a configuration that controls the concentration of oxygen produced by the electrolysis system.

3. The implantable oxygenator of claim 2 wherein the internal control system has a configuration that wirelessly receives control information indicative of a desired concentration of oxygen to be produced by the electrolysis system and controls the concentration of oxygen produced by the electrolysis system in accordance with this received information.

4. The implantable oxygenator of claim 2 wherein the internal control system includes an oxygen sensor having a configuration that senses the concentration of oxygen produced by the electrolysis system.

5. The implantable oxygenator of claim 1 further comprising an internal control system having a configuration that controls when oxygen is produced by the electrolysis system.

6. The implantable oxygenator of claim 5 wherein the internal control system has a configuration that wirelessly receives control information indicative of when oxygen should be produced by the electrolysis system and controls the production of oxygen produced by the electrolysis system in accordance with this received information.

7. The implantable oxygenator of claim 1 further comprising a tack having a configuration suitable for tacking the electrolysis system to a retina of the eye.

8. The implantable oxygenator of claim 1 further comprising an electric light having a configuration suitable for controllably casting light on a retina in the eye.

9. The implantable oxygenator of claim 1 further comprising a solar cell having a configuration that receives light entering the eye and that converts the received light into electricity for use by the implantable oxygenator.

10. The implantable oxygenator of claim 1 wherein the electrolyte reservoir has a refill port.

11. The implantable oxygenator of claim 1 wherein the electrolyte reservoir includes a permeable surface that has a location that causes the permeable surface to be in contact with fluid within the eye after the electrolyte reservoir is implanted within the eye and that is permeable to the fluid so as to facilitate transfer of the fluid into the electrolyte reservoir via osmosis.

12. The implantable oxygenator of claim 1 wherein the electrolysis system uses two different types of material to form a compartment, one of the materials having a diffusivity to O 2 that is different than the diffusivity to O 2 of the other surface.

13. The implantable oxygenator of claim 1 wherein the electrolysis bag is U-shaped.

14. A method for oxygenating an area within a human eye within a human body, the human body having an eye that includes a pupil, a sclera surrounding a volume of the eye, and a macula, the method comprising: implanting an electrolyte reservoir within the human body outside of the volume of the eve surrounded by the sclera; implanting an electrolysis system that is separate from and not part of the electrolyte reservoir having an electrolysis bag containing electrodes and that performs electrolysis on electrolyte, thereby producing oxygen in the region of the electrolysis bag, in the volume surrounded by the sclera such that the electrolysis bag straddling the macula, but is not substantially within the pathway of light traveling though the pupil to the macula and transferring electrolyte from the electrolyte reservoir through a cannula to the electrolysis bag.

15. The method of claim 14 further comprising activating the electrolysis system so as to cause it to generate oxygen.

16. The method of claim 14 further including tacking the electrolysis system to a retina in the eye.

17. The method of claim 14 further comprising implanting the electrolyte reservoir under the conjunctiva of the eye and above the sclera.

18. The method of claim 14 wherein:

the electrolysis system uses two different types of material to form a compartment, one of the materials having a diffusivity to O 2 that is different than the diffusivity to O 2 of the other surface; and

the implanting of the electrolysis system orients the electrolysis system such that the material with the higher diffusivity to O 2 faces the retina of the eye, while the material with the lower diffusivity to O 2 faces the lens of the eye.

19. The method of claim 14 wherein the electrolysis bag is U-shaped.

20. An oxygenator implanted within a human body, the human body having an eye that includes a pupil, a sclera surrounding a volume of the eye, and a macula, the oxygenator comprising an electrolysis bag containing electrodes and that performs electrolysis on electrolyte, thereby producing oxygen in the region of the electrolysis bag, the electrolysis bag being within the volume surrounded by the sclera and straddling the macula, but not substantially within the pathway of light traveling though the pupil to the macula.

Assignments (5)
CONFIRMATORY LICENSE Recorded Nov 14, 2022
From: UNIVERSITY OF SOUTHERN CALIFORNIA
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 061933/0694 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 1, 2016
From: MURALI, KARTHIK
To: UNIVERSITY OF SOUTHERN CALIFORNIA
Reel/Frame 038170/0974 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 1, 2016
From: HUMAYUN, MARK S.
To: UNIVERSITY OF SOUTHERN CALIFORNIA; DOHENY EYE INSTITUTE
Reel/Frame 038171/0006 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 1, 2016
From: RIBEIRO, RAMIRO
To: DOHENY EYE INSTITUTE
Reel/Frame 038171/0030 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 1, 2016
From: TAI, YU-CHONG; SCIANMARELLO, NICHOLAS
To: CALIFORNIA INSTITUTE OF TECHNOLOGY
Reel/Frame 038171/0067 →
Continuity (2)
Provisional Application 61710233 · Oct 5, 2012
Related Publication 20150273197A1 · Oct 1, 2015