System with photonic biopsy device for obtaining pathological information
A biopsy device includes a tubular member, a hollow shaft and an elongated fiber body having at least one optical fiber. The hollow shaft has a laterally (sidewardly) facing notch in its distal portion. The tubular member is movable relative to the shaft, between a first position in which the notch is covered by the tubular member, and a second position in which the notch is not covered by the tubular member. The shaft is movable between a first position in which the distal end of the optical fiber is located at the distal end of the shaft with the elongated fiber body extending through the notch, and a second position in which the distal end of the at least one optical fiber is located proximally to the notch.
1. A method for obtaining pathological information regarding a tissue sample of a tissue using a biopsy device comprising a tubular member, a hollow shaft having a distal end, the hollow shaft having a sidewardly facing notch adjacent the distal end of the hollow shaft, wherein the hollow shaft is movably accommodated within the tubular member, and an elongated fiber body including at least one optical fiber, the at least one optical fiber having a distal end, wherein the fiber body is accommodated within the hollow shaft, the method comprising acts of:
positioning the at least one optical fiber at a distal tip of the distal end of the hollow shaft;
performing in-vivo tissue inspection by positioning the biopsy device within the tissue;
obtaining information from the in-vivo tissue inspection;
obtaining the tissue sample using the biopsy device by keeping the elongated fiber body at a same position adjacent to the tissue sample while initially moving the hollow shaft from a first position in which the sidewardly facing notch is covered by the tubular member and the distal end of the at least one optical fiber is located at a distal tip of the distal end of the hollow shaft with the elongated fiber body extending through the sidewardly facing notch, to a second position in which the notch is not covered by the tubular member and the distal end of the at least one optical fiber is located proximally to the sidewardly facing notch, and then moving the tubular member to a location in which the sidewardly facing notch is covered by the tubular member;
performing ex-vivo tissue inspection on the tissue sample obtained using the biopsy device;
obtaining information from the act of performing the ex-vivo tissue inspection using a tissue analyzer,
wherein the same tissue sample is subjected to the in-vivo tissue inspection and to the ex-vivo tissue inspection.
2. The method of claim 1 , wherein the in-vivo tissue inspection includes at least one out of the group consisting of diffuse reflectance spectroscopy, fluorescence spectroscopy, diffuse optical tomography, differential path length spectroscopy, and Raman spectroscopy.
3. The method of claim 1 , wherein the ex-vivo tissue inspection includes at least one of making tissue slices, staining by Hematoxylin and eosin and/or a specific biomarker, and optically scanning.
4. The method of claim 1 , further comprising an act of integrating the information obtained by the in-vivo tissue inspection and the information obtained by the ex-vivo tissue inspection.
5. The method of claim 1 , further comprising an act of storing the pathological information of the tissue sample in a memory of a storage container which is further configured to receive the tissue sample.