Cancer cell trap

1. A method for treating cancer metastasis comprising administering to a subject in need thereof an effective amount of a cancer cell trap, wherein the cancer cell trap comprises

i. microparticles;

ii. nanoparticles;

iii. a scaffold structure; or

iv. a hydrogel,

wherein circulating cancer cells are recruited to the cancer cell trap;

wherein the circulating cancer cells are selected from the group consisting of leukemia cells, melanoma cells, prostate cancer cells, and lung cancer cells,

wherein the cancer cell trap comprises erythropoietin (EPO) that is released from the cancer cell trap, wherein the EPO enables recruitment and accumulation of circulating cancer cells in the cancer cell trap, and

wherein the cancer cell trap further comprises a chemotherapeutic agent and/or the method further comprises subjecting the cancer cell trap to radiation.

2. The method of claim 1 , wherein the scaffold structure comprises a degradable polymer and polypeptides.

3. The method of claim 1 , wherein the cancer cell trap comprises PLGA, albumin, collagen, gelatin, immunoglobulins, extracellular matrix proteins, fibronectin and combinations thereof.

4. The method of claim 1 , wherein the cancer cell trap is implanted into the subject.

5. The method of claim 1 , wherein the cancer cell trap is injected into the subject.

6. The method of claim 1 , wherein the subject is a human.

7. The method of claim 1 , wherein the chemotherapeutic agent is a member selected from the group consisting of cytotoxic agents, DNA-alkylating agents, anti-tumor antibiotic agents, anti-metabolic agents, tubulin stabilizing agents, tubulin destabilizing agents, hormone antagonist agents, topoisomerase inhibitors, protein kinase inhibitors, HMG-CoA inhibitors, CDK inhibitors, cyclin inhibitors, caspase inhibitors, metalloproteinase inhibitors, antisense nucleic acids, triple-helix DNAs, nucleic acids aptamers, and molecularly-modified viral, bacterial, exotoxic agents, and combinations thereof.