Radiopaque marker for bioresorbable stents
The present patent application relates to a method of applying a radiopaque marker to a tubular stent. A radiopaque marker for a tubular stent is constructed of a radiopaque material and configured with a roof portion and a pair of wall portions extending approximately perpendicular to the roof portion. The radiopaque marker is applied to a tubular stent by a method including the steps of forming the tubular stent with a pair of openings through a wall of the tubular stent; inserting the wall portions of the radiopaque marker into the openings in the wall of the tubular stent; and heat treating the tubular stent to retain the wall portions of the radiopaque marker within the openings in the wall of the tubular stent. The heat treating step also embeds the roof portion of the radiopaque marker onto the wall of the tubular stent. The method of the invention is particularly adapted for applying a radiopaque marker to a bioresorbable polymeric vascular stent.
1. A method of applying a radiopaque marker to a bioresorbable polymeric tubular stent, the method comprising:
forming a tubular stent with at least one opening through a wall of the tubular stent, the wall of the tubular stent being constructed of a bioresorbable polymeric material and the at least one opening comprising a pair of slits;
inserting a portion of a radiopaque metal marker into the opening in the wall of the tubular stent wherein the radiopaque metal marker comprises a pair of wall portions sized and configured to fit within the slits and a roof portion joining together the pair of wall openings; and then
heat treating the tubular stent to retain the portion of the radiopaque marker within the opening in the wall of the tubular stent, wherein the heat treating step embeds the walls and the roof portion of the radiopaque marker into the wall of the tubular stent.
2. The method of claim 1 , wherein the tubular stent is formed from a polymer having a glass transition temperature and wherein the heat treating step comprises heating the tubular stent to a temperature at or above the glass transition temperature.
3. The method of claim 1 , further comprising after the heat treating step, cooling the tubular stent to a temperature below the glass transition temperature.
4. The method of claim 1 , wherein the tubular stent comprises a poly (lactic acid) polymer.
5. The method of claim 1 , further comprising prior to the heat treating step, placing an internal support rod into the tubular stent and placing the tubular stent into an outer mold.
6. The method of claim 5 , wherein the outer mold comprises a lower half having at least one semicylindrical channel and an upper half having at least one semicylindrical channel.
7. The method of claim 1 wherein the pair of slits is located at an X-shaped juncture between two adjacent cells of the stent.
8. A tubular stent directly obtained with a method according to claim 1 .