Modulators of resistant androgen receptor
The present invention provides compounds useful as modulators, agonists or antagonists of androgen receptor (AR), compositions thereof, and methods of making and using the same. Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful in medicine, and particularly for treating any of a variety of diseases, disorders or conditions.
1. A compound of formula IV:
or a pharmaceutically acceptable salt thereof, wherein:
X is CH or N;
each R b is independently a substituted or unsubstituted C 1-6 aliphatic; and
n is 0 to 4.
2. The compound according to claim 1 , wherein the compound is:
3. A pharmaceutical composition comprising a compound according to claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant, or vehicle.
4. The compound of claim 1 , wherein the compound is represented by the following structural formula:
5. The compound of claim 1 , wherein the compound is represented by the following structural formula: