Antibodies against chikungunya virus and uses thereof
Embodiments disclosed herein provide for antibodies, including neutralizing antibodies, against Chikungunya virus, uses thereof, and methods of identifying antibodies, including neutralizing antibodies, against Chikungunya virus. In some embodiments, antibodies that binds to a CHIKV antigen, wherein the antigen is the CHIKV E1, E2, E3 protein, or any heterocomplex thereof are provided. In some embodiments, the antibody is an isolated antibody, a neutralizing antibody, a recombinant antibody, or any combination thereof. In some embodiments, the antibodies described herein bind to an epitope of E2 Domain A, E2 Domain B, or E1 Domain II of the CHIKV antigen. In some embodiments, the antigen is E2 protein.
1. A recombinant antibody comprising a first amino acid sequence comprising the amino acid sequence of SEQ ID NO: 13 and a second amino acid sequence comprising the amino acid sequence of SEQ ID NO: 14.
2. A composition comprising the antibody of claim 1 and a buffer.
3. The composition of claim 2 , wherein the composition is a pharmaceutical composition further comprising a pharmaceutically acceptable excipient.