Heterocyclic substituted 2-amino quinazoline derivatives for the treatment of viral infections

1. A compound of formula (I)

or a pharmaceutically acceptable salt, tautomer(s), stereo-isomeric forms or polymorph thereof, wherein

R 1 is selected from the group consisting of:

R 2 is selected from the group consisting of hydrogen, —O—(C 1-3 )-alkyl, halogen, (C 1-3 )-alkyl, —O—(C 1-3 )-alkyl-O—(C 1-3 )-alkyl and CH 2 OH;

R 3 is selected from the group consisting of hydrogen, —O—(C 1-3 )-alkyl, halogen, (C 1-3 )-alkyl and —C(═O)—R 7 , wherein R 7 is —O—(C 1-3 )-alkyl, NH 2 , NH(CH 3 ), N(CH 3 ) 2 , N(CH 3 )(C 1-3 )-alkyl, N((C 1-3 )-alkyl) 2 or pyrolidine;

R 4 is hydrogen or fluorine;

R 5 is selected from the group consisting of (C 1-3 )-alkyl, (C 1-3 )-fluoro-alkyl, and CH 2 OH;

R 6 is selected from the group consisting of NH 2 , NH(CH 3 ), N(CH 3 ) 2 , and (hetero)-aniline, wherein said (hetero)-aniline- is optionally substituted with one or more of R 8 , R 9 , R 10 R 11 or R 12 or (hetero)-benzylamine, wherein the (hetero)-benzylamine is optionally substituted with one or more of R 8 , R 9 , R 10 R 11 or R 12 , wherein R 8 , R 9 , R 10 , R 11 and R 12 which are the same or different, are each independently selected from the group consisting of hydrogen, (C 1-3 )-alkyl, —O—(C 1-3 )-alkyl and halogen; and

R 13 is selected from the group consisting of hydrogen, (C 1-3 )-alkyl and (C 1-3 )-fluoro-alkyl.

2. A substituted 2-amino-4-hydroxyquinazoline having the following formula

3. A compound of claim 1 , wherein R 1 is

4. A compound as claimed in claim 1 , wherein R 9 is CH 3 .

5. A compound as claimed in claim 1 , wherein R 2 is OCH 3 or —O—(C 1-3 )-alkyl-O—(C 1-3 )-alkyl.

6. A compound as claimed in claim 1 , wherein

R 3 , R 4 , R 13 and R 8 are each H;

R 9 is CH 3 ;

R 2 is —O—(C 1-3 )-alkyl-O—(C 1-3 )-alkyl; and

R 1 is

7. A compound as claimed in claim 1 , wherein

R 3 , R 4 , R 13 and R 8 are each H;

R 9 is CH 3 ;

R 2 is OCH 3 ; and

R 1 is

8. A compound as claimed in claim 1 , said compound selected from the group consisting of

9. A pharmaceutical composition comprising a compound as claimed in claim 1 together with one or more pharmaceutically acceptable excipients, diluents or carriers.