Antimicrobial foaming compositions containing cationic active ingredients
The antimicrobial foaming composition of the present invention comprises a cationic active ingredient, a cationic compatible surfactant, a foam booster, a foam structure enhancing agent, dermal adjuvants, and a carrier. The present antimicrobial compositions are free of the antimicrobial agents triclosan (i.e., 2,4,4′-trichloro-2′hydroxy-diphenylether) and lower alcohols. They are also free of anionic surfactants. The foaming compositions have rapid cidal activity, provide stable, copious foam, and exhibit enhanced tissue (e.g. skin) compatibility.
1. A foaming antimicrobial dermal cleanser comprising:
a. a cationic active ingredient;
b. from about 10 wt. % to about 12.5 wt. % of a cationic compatible surfactant, wherein the cationic compatible surfactant is an alkyl amine oxide and/or an alkyl ether amine oxide;
c. from about 0.01 wt. % to about 1 wt. % of a foam boosting agent, wherein the foam boosting agent is selected from the group consisting of: glyceryl caprylate/caprate, sorbitan sesquicaprylate, phospholipids, polyethylene glycol dimethicone with methylesters, polyethylene glycol-7 glyceryl coco-ate, capris/caprylic monoglycerides, hydrophobically modified cationic polymers, and combinations thereof;
d. from about 5 wt. % to about 8 wt. % a foam structure enhancing agent;
e. a skin conditioning agent; and
f. a water;
wherein the cleanser is substantially free of anionic surfactants and triclosan.
2. The foaming antimicrobial dermal cleanser of claim 1 , wherein the cleanser comprises about 0.01 wt. % to about 10 wt. % of the cationic active ingredient.
3. The foaming antimicrobial dermal cleanser of claim 1 , wherein the cationic active ingredient is selected from the group consisting of: a salt of a biguanide, an organic salt of a quaternary ammonium containing compound or an inorganic salt of a quaternary ammonium containing compound, and an organic salt of chlorohexidine.
4. The foaming antimicrobial dermal cleanser of claim 1 , wherein the cationic compatible surfactant component includes about 12.5 wt. % of the alkyl amine oxide and/or alkyl ether amine oxide.
5. The foaming antimicrobial dermal cleanser of claim 1 , wherein the cationic compatible surfactant is lauryl dimethyl amine oxide.
6. The foaming antimicrobial dermal cleanser of claim 1 , wherein the foam boosting agent comprises glyceryl caprylate/caprate.
7. The foaming antimicrobial dermal cleanser of claim 1 , wherein the foam structure enhancing agent is selected from the group consisting of polyethylene glycol 8000, hexylene glycol, myristamide diisopropanolamide, phenoxyethanol, and combinations thereof.
8. The foaming antimicrobial dermal cleanser of claim 1 , wherein the skin conditioning agent is selected from the group consisting of glycerin, vitamin E acetate, methyl gluceth-20, hydroxypropyl guar hydroxypropyltrimonium chloride, and combinations thereof.
9. The foaming antimicrobial dermal cleanser of claim 7 , wherein the foam structure enhancing agent is present in an amount of about 7 wt. % of the cleanser.
10. The foaming antimicrobial cleanser of claim 1 , wherein the foam structure enhancing agent is hexylene glycol.
11. The foaming antimicrobial dermal cleanser of claim 1 , wherein the foam structure enhancing agent comprises phenoxyethanol.
12. A method of reducing bacterial, microbial, fungal or viral populations on a dermal tissue of a mammal comprising the step of:
contacting the dermal tissue of the mammal with the foaming antimicrobial dermal cleanser of claim 1 for a sufficient time to provide substantial bactericidal, microbicidal, fungicidal or virucidal reduction.
13. The method of claim 12 , wherein the sufficient contact time is between about 5 to about 60 seconds.
14. The method of claim 12 , wherein the foaming antimicrobial dermal cleanser is rinsed off of the dermal tissue after contact or remains on the dermal tissue after contact.
15. A foaming antimicrobial dermal cleanser comprising:
a. a cationic active ingredient;
b. from about 10 wt. % to about 12.5 wt. % of a cationic compatible surfactant;
wherein the cationic compatible surfactant is an alkyl amine oxide and/or an alkyl ether amine oxide;
c. from about 0.01 wt. % to about 1 wt. % of a foam boosting agent, wherein the foam boosting agent is selected from the group consisting of: glyceryl caprylate/caprate, sorbitan sesquicaprylate, phospholipids, polyethylene glycol dimethicone with methylesters, polyethylene glycol-7 glyceryl cocoate, capric/caprylic monoglycerides, hydrophobically modified cationic polymers, and combinations thereof;
d. from about 5 wt. % to about 8 wt. % of a foam structure enhancing agent;
e. a dermal adjuvant; and
f. water;
wherein the cleanser is substantially free of anionic surfactants, lower alcohols, and triclosan.
16. The foaming antimicrobial dermal cleanser of claim 15 , wherein the foam structure enhancing agent is selected from the group consisting of polyethylene glycol 8000, hexylene glycol, myristamide diisopropanolamide, phenoxyethanol and combinations thereof.
17. The foaming antimicrobial dermal cleanser of claim 15 , wherein the foam structure enhancing agent includes hexylene glycol.
18. The foaming antimicrobial dermal cleanser of claim 15 , wherein the cationic compatible surfactant is lauryl dimethyl amine oxide.
19. The foaming antimicrobial dermal cleanser of claim 15 , further comprising a preservative.