IP Library › Granted Patent US 10,034,936
Granted Patent B2
US 10,034,936 · App. 14/460,517 · Granted Jul 31, 2018

Method of inducing a cross-reactive HIV-1 immune response by administering a composition comprising the GBV-C E2 protein

Inventors: Jack T. Stapleton (Iowa City, IA); Jinhua Xiang (Iowa City, IA); Donna Klinzman (Coralville, IA); James H. McLinden (Coralville, IA)
Assignees: The University of Iowa Research Foundation; The United States of America as represented by the Secretary of the Department of Veterans Affairs
A61K39/29C07K14/05C07K16/109A61K2039/505C07K14/1841C07K2317/34C12N7/00C12N2770/24222C12N2770/24234
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Quick Facts
Patent No.
US 10,034,936
App. No.
14/460,517
Granted
Jul 31, 2018
Kind
B2
Abstract

GB virus C (GBV-C or hepatitis G virus) is a flavivirus that frequently leads to chronic viremia in humans. The invention provides compositions and methods involving an anti-GBV-C antibody or other GBV-C binding agent, or a GBV-C antigen, for inhibiting and treating HIV infections.

Claims (5)

1. A method of inducing a cross-reactive anti-HIV-1 immune response in a subject comprising contacting said subject with an immunogenic composition comprising a GBV-C E2 polypeptide or fragment thereof comprising an epitope defined by GGAGLTGGFYEPLVRRC (SEQ ID NO:7) dispersed in a pharmaceutical carrier, buffer or medium.

2. The method of claim 1 , wherein said immunogenic composition further comprises an adjuvant.

3. The method of claim 1 , wherein said immunogenic composition comprises a full length GBV-C E2 polypeptide.

4. The method of claim 1 , wherein said immunogenic composition comprises GBV-C E2 fragment.

5. The method of claim 1 , wherein the polypeptide or fragment is linked to a carrier molecule.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 26, 2018
From: STAPLETON, JACK T.; XIANG, JINHUA; KLINZMAN, DONNA; MCLINDEN, JAMES H.
To: THE UNIVERSITY OF IOWA RESEARCH FOUNDATION; THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF VETERANS AFFAIRS
Reel/Frame 044738/0897 →
CONFIRMATORY LICENSE Recorded Oct 15, 2014
From: UNIVERSITY OF IOWA
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 033991/0626 →
Continuity (4)
Division 12179399 · Jul 24, 2008
Division 10862061 · Jun 4, 2004
Provisional Application 60475987 · Jun 5, 2003
Related Publication 20140348866A1 · Nov 27, 2014