Inhibitors of hepatitis C virus replication

1. A compound having structural formula (I):

and/or a pharmaceutically acceptable salt thereof, wherein:

 is

 which is substituted by u substituents R 1 ,

each R 1 is independently chosen from the group consisting of hydrogen, halogen, —OR 3a , —CN, —(CH 2 ) 0-6 C(O)R 3 , —CO 2 R 3a , —C(O)N(R 3a ) 2 , —SR 3a , —S(O)R 3a , —S(O)R 3a , —(CH 2 ) 0-6 N(R 3a ) 2 , —N(R 3a )SO 2 R 3a , —N(R 3a )CO 2 R 3 a, —N(R 3a )C(O)R 3 , —N(R 3a )COR 3a , —N(R 3a )C(O)N(R 3a ), C 1-6 alkyl, C 3-8 carbocycle containing from 0 to 3 heteroatoms chosen from N, O and S, and phenyl, and the C 1-6 alkyl, C 3-8 carbocycle and phenyl are substituted by from 0 to 3 substitutents independently chosen from the group consisting of hydrogen, halogen, —OR 3a , —CN, —CO 2 R 3a , —C(O)N(R 3a ) 2 , —N(R 3a ) 2 , —N(R 3a )CO 2 R 3a , —SR 3a , —S(O)R 3a , —S(O 2 )R 3a , —N(R 3a )SO 2 R 3a , —N(R 3a )CO 2 R 3a , —N(R 3a )C(O)N(R 3a ), C 1-6 alkyl, —O—C 1-6 alkyl, —S—C 1-6 alkyl, and C 3-8 cycloalkyl,

u is from 0 to 4,

each R 3 is independently chosen from the group consisting of hydrogen, C 1-6 alkyl, —OH, —O—C 1-6 alkyl and C 3-8 cycloalkyl, and

each R 3a is independently chosen from the group consisting of hydrogen, C 1-6 alkyl and C 3-8 cycloalkyl;

 is phenyl, which is substituted by v substituents R 2 ,

each R 2 is independently chosen from the group consisting of hydrogen, halogen, —OR 4a , —CN, —CO 2 R 4a , —C(O)R 4a , —C(O)N(R 4a ) 2 —N(R 4a ) 2 , —N(R 4a )COR 4 , —N(R 4a )CO 2 R 4a , —N(R 4a )C(O)N(R 4a ), —N(R 4a )SO 2 R 4a , —SR 4a , —S(O)R 4a , —S(O 2 )R 4a , C 1-6 alkyl substituted by from 0 to 4 R 4 and C 3-8 cycloalkyl substituted by from 0 to 4 R 4 ,

v is from 0 to 4,

each R 4 is independently chosen from the group consisting of hydrogen, —OH, C 1-6 alkyl and C 3-8 cycloalkyl;

each R 4a is independently chosen from the group consisting of hydrogen, C 1-6 alkyl and C 3-8 cycloalkyl;

each D is independently a 5- or 6-membered aryl ring system D′ containing from 0 to 4 heteroatoms independently chosen from the group consisting of N, O and S, and substituted on C or N atoms by from 0 to 2 substituents R 5 ,

each R 5 is independently chosen from the group consisting of hydrogen, halogen, —OR 6 , —CN, —CO 2 R 6 , —C(O)N(R 6 ) 2 , —N(R 6 ) 2 , —N(R 6 )COR 6 , —SR 6 , —S(O)R 6 , —S(O 2 )R 6 , —N(R 6 )SO 2 R 6 , —NCO 2 R 6 , —NC(O)N(R 6 ) 2 , C 1-6 alkyl substituted by from 0 to 3 R 6 and C 3-8 cycloalkyl substituted by from 0 to 3 R 6 , and

each R 6 is independently chosen from the group consisting of hydrogen, C 1-6 alkyl and C 3-8 cycloalkyl;

each E is a pyrrolidinyl derivative chosen from the group consisting of:

I is a bivalent group chosen from —C(O)—, —CO 2 — and —C(O)N(R 7 )—,

J is a fused ring system chosen from the group consisting of 3- to 7-membered carbocycles and 5- or 6-membered aryl rings containing from 0 to 4 heteroatoms independently chosen from the group consisting of N, O and S, and substituted on C or N atoms by substituents R 9 ,

each R 8a is independently chosen from the group consisting of hydrogen, halogen, —OH, —OC 1-6 alkyl and C 1-6 alkyl, or two R 8a may be taken together to form oxo,

each R 8b is independently chosen from the group consisting of hydrogen, halogen, —OH, —OC 1-6 alkyl and C 1-6 alkyl, or two R 8b may be taken together to form oxo,

each R 8c is independently chosen from the group consisting of hydrogen and C 1-6 alkyl,

or any two groups selected from R 8a , R 8b and R 8c may be taken together to form a spiro-bicyclic or bridged bicyclic ring;

each R 9 is independently chosen from the group consisting of hydrogen, halogen, C 1-6 alkyl, —O—C 1-6 alkyl, —S—C 1-6 alkyl, —NH—C 1-6 alkyl and —NHC(O)—C 1-6 alkyl; and

each G is independently chosen from the group consisting of:

(a) hydrogen,

(b) —OR 10a ,

(c) —CN,

(d) —CO 2 R 10a ,

(e) —C(O)N(R 10 ) 2 ,

(f) —SR 10a ,

(g) —S(O)R 10a ,

(h) —S(O 2 )R 10a ,

(i) —N(R 10 ) 2 ,

(j) —N(R 10 )SO 2 R 10a ,

(k) —NCO 2 R 10a ,

(l) —NC(O)N(R 10 ) 2 ,

(m) C 1-6 alkyl having 0 to 4 substituents R 11 ,

each R 11 is independently chosen from the group consisting of:

(i) —OH,

(ii) —N(R 10 ) 2 ,

(iii) ═NR 10 ,

(iv) —O —C 1-6 alkyl,

(v) —C(O)R 10 ,

(vi) —S—C 1-6 alkyl,

(vii) —SO 2 —C 1-6 alkyl,

(viii) 3- to 8-membered carbocycles containing from 0 to 3 heteroatoms independently chosen from the group consisting of N, O and S, and having from 0 to 3 substitutents R 12 on N or C atoms, and each R 12 is independently selected from the group consisting of hydrogen, halogen, C 1-6 alkyl having from 0 to 3 substituents chosen from R 10 , —O—C 1-6 alkyl, —S—C 1-6 alkyl, —OR 10a , —CN, —C(O)R 10 , —CO 2 R 10a , —C(O)N(R 10 ) 2 , —SR 10a , —S(O)R 10a , —S(O 2 )R 10a , —N(R 10 )SO 2 R 10a , —NCO 2 R 10a , —NC(O)N(R 10 ) 2 and —N(R 10 ) 2 , or two R 12 are taken together to form oxo, and

(ix) 5- or 6-membered aryl containing from 0 to 3 heteroatoms independently chosen from the group consisting of N, O and S, and having from 0 to 3 substitutents R 13 on N or C atoms, and each R 13 is independently selected from the group consisting of hydrogen, halogen, C 1-6 alkyl, —O—C 1-6 alkyl and 3- to 8-membered carbocycles containing from 0 to 3 heteroatoms independently chosen from the group consisting of N, O and S,

(n) 3- to 8-membered carbocycles containing from 0 to 3 heteroatoms independently chosen from the group consisting of N, O and S, and having from 0 to 3 substitutents R 10 on N or C atoms; and

(o) aryl ring systems G′ chosen from the group consisting of:

(i) 5- to 7-membered monocyclic ring systems and

(ii) 8- to 10-membered bicyclic ring systems,

and the aryl ring systems G′ containing from 0 to 4 heteroatoms independently chosen from the group consisting of N, O and S, and substituted on C or N atoms by 0 to 3 substitutents R 10 ;

each R 10 is independently chosen from the group consisting of

(i) hydrogen,

(ii) —CN,

(iii) C 1-6 alkyl,

(iv) —O—C 0-6 alkyl,

(v) —S—C 0-6 alkyl,

(vi) C 1-6 alkyl-O—R 14 ,

(vii) —C(O)R 14 ,

(viii) —CO 2 R 14 ,

(ix) —SO 2 R 14 ,

(x) —N(R 14 ) 2 ,

(xi) —N(R 14 )SO 2 R 14 ,

(xii) —NCO 2 R 14 ,

(xiii) —NC(O)N(R 14 ) 2 , and

(xiv) 3- to 8-membered carbocycles containing from 0 to 3 heteroatoms independently chosen from the group consisting of N, O and S,

or two R 10 may be taken together to form oxo;

each R 10a is independently chosen from the group consisting of

(i) hydrogen,

(ii) —CN,

(iii) C 1-6 alkyl,

(iv) C 1-6 alkyl-O—R 14 ,

(v) —C(O)R 14 ,

(vi) —CO 2 R 14 ,

(vii) —SO 2 R 14 ,

(x) —N(R 14 ) 2 ,

(xi) —N(R 14 )SO 2 R 14 ,

(xii) —NCO 2 R 14 ,

(xiii) —NC(O)N(R 14 ) 2 , and

(xiv) 3- to 8-membered carbocycles containing from 0 to 3 heteroatoms independently chosen from the group consisting of N, O and S,

and two R 10 or R 10a groups can be taken together with the N to which they are attached to form a ring, which may be substituted by from 0 to 3 substituents R 14 , and

each R 14 is independently chosen from the group consisting of hydrogen, C 1-6 alkyl, C 3-8 cycloalkyl, —(CH 2 ) 0-3 C 3-8 cycloalkyl and phenyl.

2. The compound according to claim 1 , wherein each R 1 is chosen from the group consisting of hydrogen, fluorine and —CN.

3. The compound according to claim 1 , wherein

v is from 0 to 4,

each R 2 is independently chosen from the group consisting of hydrogen, halogen, —OR 4a , —CN, —CO 2 R 4a , —C(O)N(R 4a ) 2 , —N(R 4a ) 2 , —N(R 4a )CO 2 R 4a , —SR 4a , —S(O)R 4a , —S(O 2 )R 4a , —N(R 4a )SO 2 R 4a , —N(R 4a )CO 2 R 4a , —N(R 4a )C(O)N(R 4a ), C 1-6 alkyl substituted by from 0 to 4 R 4 and C 3-8 cycloalkyl substituted by from 0 to 4 R 4 ,

each R 4 is independently chosen from the group consisting of hydrogen, —OH, C 1-6 alkyl and C 3-8 cycloalkyl, and

each R 4a is independently chosen from the group consisting of hydrogen, C 1-6 alkyl and C 3-8 cycloalkyl.

4. The compound according to claim 1 , wherein each D is independently chosen from the group consisting of

5. The compound according to claim 1 , wherein each E is independently chosen from the group consisting of

where one of R 8a and R 8b is —OH or fluorine.

6. The compound according to claim 1 , wherein each G is independently chosen from the group consisting of

(a) hydrogen,

(b) —CN,

(c) C 1-5 alkyl having 1 to 3 substituents R 11 ,

each R 11 is independently chosen from the group consisting of —OH, —NH 2 , —NCH 3 H, —N(CH 3 ) 2 , —N(CH 2 CH 3 ) 2 , ═NH, ═NCH 3 , —C(O)H, —C(O)OH, —C(O)CH 3 , —C(O)OCH 3 , —NHC(O)H, —NHC(O)OH, —NHC(O)CH 3 , —NHC(O)OCH 3 , cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, pyranyl, pyrrolidinyl, piperidinyl, oxacyclopentyl, and oxacyclohexyl, phenyl, pyridinyl, pyrimidinyl and pyrrolyl, where

the cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, pyranyl, pyrrolidinyl, piperidinyl, oxacyclopentyl and oxacyclohexyl are substituted by from 0 to 2 substitutents R 12 on N or C atoms, and each R 12 is independently selected from the group consisting of hydrogen, halogen, carboxy, C 1-6 alkyl, —O—C 1-6 alkyl and —S—C 1-6 alkyl; and

the phenyl, pyridinyl, pyrimidinyl and pyrrolyl are substituted by from 0 to 3 substitutents R 13 on N or C atoms, and each R 13 is independently selected from the group consisting of hydrogen, halogen, C 1-6 alkyl and 3- to 8-membered cycloalkyl containing from 0 to 3 heteroatoms independently chosen from the group consisting of N, O and S,

(d) cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, pyranyl, pyrrolidinyl, piperidinyl, oxacyclopentyl and oxacyclohexyl having from 0 to 3 substitutents R 10 on N or C atoms, said R 10 independently selected from the group consisting of hydrogen, halogen, carboxy, C 1-6 alkyl, —O—C 1-6 alkyl, —S—C 1-6 alkyl, phenyl and benzyl, and

(e) aryl ring systems G′ chosen from the group consisting of: phenyl, pyridinyl and 9-membered bicyclic ring systems containing from 0 to 2 heteroatoms independently chosen from the group consisting of N and O.

7. The compound according to claim 1 , wherein

said

 is

 where said

 is substituted by from 0 to 3 additional R 1 ;

v is from 0 to 2;

each R 2 is independently chosen from the group consisting of fluorine, chlorine, —OH, —CH 3 , —OCH 3 and —CN;

each D is independently chosen from the group consisting of

each E is independently chosen from the group consisting of

 where one of R 8a and R 8b is —OH or fluorine; and

each G is independently chosen from the group consisting of C 1-4 alkyl having 1 to 2 substituents R 11 , wherein each R 11 is independently chosen from the group consisting of —OH, —NH 2 , —NCH 3 H, —N(CH 3 ) 2 , —N(CH 2 CH 3 ) 2 , —C(O)OCH 3 , cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, pyranyl, pyrrolidinyl, piperidinyl, oxacyclopentyl, oxacyclohexyl, phenyl, pyridinyl, pyrimidinyl and pyrrolyl.

8. The compound according to according to claim 1 , wherein the compound having structural formula (I) is a compound having structural formula (Ib):

or a pharmaceutically acceptable salt thereof, wherein said

 is substituted by u substituents R 1 , and Y is O.

9. The compound according to according to claim 8 , wherein said

is substituted by u substituents R 1 , Y is O, and both instances of G are

10. The compound according to according to claim 1 , wherein the compound having structural formula (I) is a compound having structural formula (Ib):

or a pharmaceutically acceptable salt thereof, wherein said

 is substituted by u substituents R 1 , Y is O, and both instances of G are

11. A compound according to claim 1 , chosen from the group consisting of:

propan-2-yl[(1R)-2-{(2S)-2-[(4-{3-bromo-5-[({(2S)-1-[(2R)-2-phenyl-2-{[(propan-2-yloxy)carbamonyl]amino}acetyl]pyrrolidin-2-yl}carbonyl)amino]-1-benzofuran-2-yl}phenyl)carbamoyl]pyrrolidin-1-yl}-2-oxo-1-phenylethyl]carbamate;

(2S)-N-(4-{3-bromo-5-[({(2S)-1-[(2R)-2-(dimethylamino)-2-phenylacetyl]pyrrolidin-2-yl}carbonyl)amino]-1-benzofuran-2-yl}phenyl)-1-[(2R)-2-(dimethylamino)-2-phenylacetyl]pyrrolidine-2-carboxamide;

methyl{(1R)-2-[(2S)-2-({4-[3-bromo-5-({[(2S)-1-{(2R)-2-[(methoxycarbonyl)amino]-2-phenylacetyl}pyrrolidin-2-yl]carbonyl}amino)-1-benzofuran-2-yl]phenyl}carbamoyl)pyrrolidin-1-yl]-2-oxo-1-phenylethyl}carbamate;

methyl{(2S)-1-[(2S)-2-({4-[3-fluoro-5-({[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidin-2-yl]carbonyl}amino)-1H-indol-2-yl]phenyl}carbamoyl)pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate;

N-{2-[4-(acetylamino)phenyl]-3-bromo-1-benzofuran-5-yl}-1-[(2R)-2-(dimethylamino)-2-phenylacetyl]-L-prolinamide;

tert-butyl {(1S)-2-[(2S)-2-({4-[3-bromo-5-({[(2S)-1-{(2S)-2-[(tert-butoxycarbonyl)amino]-2-phenylacetyl}pyrrolidin-2-yl]carbonyl}amino)-1-benzofuran-2-yl]phenyl}carbamoyl)pyrrolidin-1-yl]-2-oxo-1-phenylethyl}carbamate);

(2S)-N-{4-[3-bromo-5-({[(2S)-1-phenylacetyl)pyrrolidin-2-yl]carbonyl}amino)-1-benzofuran-2-yl]phenyl}-1-(phenylacetyl)pyrrolidine-2-carboxamide;

tert-butyl{(1R)-2-[(2S)-2-({4-[3-bromo-5-({[(2S)-1-{(2R)-2-[(tert-butoxycarbonyl)amino]-2-phenylacetyl}pyrrolidin-2-yl]carbonyl}amino)-1-benzofuran-2-yl]phenyl}carbamoyl)pyrrolidin-1-yl]-2-oxo-1-phenylethyl}carbamate;

methyl{(2S)-1-[(2S)-2-{5-[4-(5-{2-[(2S)-1-{(2S)-2-[(methoxy-carbonyl)amino]-3-methylbutanoyl}pyrrolidin-2-yl]-1H-imidazol-5-yl}-1-benzofuran-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate;

(2R)-2-(diethylamino)-1-[(2S)-2-(5-{4-[5-(2-{(2S)-1-[(2R)-2-(diethylamino)-2-phenylacetyl]pyrrolidin-2-yl}-1H-imidazol-5-yl)-1-benzofuran-2-yl]phenyl}-1H-imidazol-2-yl)pyrrolidin-1-yl]-2-phenylethanone;

methyl{(1S)-1-cyclopropyl-2-[(2S)-2-{5-[4-(5-{2-[(2S)-1-{(2S)-2-cyclopropyl-2-[(methoxycarbonyl)amino]acetyl}pyrrolidin-2-yl]-1H-imidazol-5-yl}-1-benzofuran-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-2-oxoethyl}carbamate;

methyl{(1R)-1-cyclopropyl-2-[(2S)-2-{5-[4-(5-{2-[(2S)-1-{(2R)-2-cyclopropyl-2-[(methoxycarbonyl)amino]acetyl}pyrrolidin-2-yl]-1H-imidazol-5-yl}-1-benzofuran-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-2-oxoethyl}carbamate;

methyl{(2R)-1[(2S)-2-{5-[2-(4-{2-[(2S)-1-{(2R)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidin-2-yl]-1H-imidazol-5-yl }phenyl)-1-benzofuran-5-yl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate;

methyl{(2S)-1-[(2S)-2-{5-[4-(5-{2-[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3,3-dimethylbutanoyl}pyrrolidin-2-yl]-1H-imidazol-5-yl}-1-benzofuran-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3 ,3-dimethyl-1-oxobutan-2-yl}carbamate;

methyl{(1R)-2-[(2S)-2-{5-[4-(5-{2-[(2S)-1-{(2R)-2-[(methoxycarbonyl)amino]-2-phenylacetyl}pyrrolidin-2-yl]-1H-imidazol-4-yl}-1-benzofuran-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-2-oxo-1-phenylethyl}carbamate;

methyl{(2S,3R)-1-[(2S)-2-(5-{2-[4-(2-{(2S)-1-[N-(methoxycarbonyl)-L-alloisoleucyl]pyrrolidin-2-yl}-1H-imidazol-5-yl)phenyl]-1-benzofuran-5-yl}-1H-imidazol-2-yl)pyrrolidin-1-yl]-3-methyl-1-oxopentan-2-yl}carbamate;

methyl{(2S)-3-hydroxy-1-[(2S)-2-{5-[4-(5-{2-[(2S)-1-{(2S)-3-hydroxy-2-[(methoxycarbonyl)amino]propanoyl}pyrrolidin-2-yl]-1H-imidazol-5-yl}-1-benzofuran-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-1-oxopropan-2-yl}carbamate;

methyl{(2S,3R)-3-hydroxy-1-[(2S)-2-{5-[4-(5-{2-[(2S)-1-{(2S,3R)-3-hydroxy-2-[(methoxycarbonyl)amino]butanoyl}pyrrolidin-2-yl]-1H-imidazol-5-yl}-1-benzofuran-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-1-oxobutan-2-yl}carbamate;

methyl{(2S)-1-[(2S)-2-{5-[4-(5-{2-[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]-4-methylpentanoyl}pyrrolidin-2-yl]-1H-imidazol-5-yl}-1-benzofuran-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-4-methyl-1-oxopentan-2-yl}carbamate;

methyl{(2S)-1-[(2S)-2-{5-[3-fluoro-4-(5-{2-[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidin-2-yl]-1H-imidazol-5-yl}-1-benzofuran-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate;

methyl{(1R)-2-[(2S)-2-{5-[3-fluoro-4-(5-{2-[(2S)-1-{(2R)-2-[(methoxycarbonyl)amino]-2-phenylacetyl}pyrrolidin-2-yl]-1H-imidazol-5-yl}-1-benzofuran-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-2-oxo-1-phenylethyl}carbamate;

methyl{(2S)-1-[(2S)-2-{5-[3-fluoro-4-(5-{2-[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidin-2-yl]-1H-imidazol-5-yl}-1-benzofuran-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate;

methyl{(2S)-1-[(2S)-2-{5-[2-(2,6-difluoro-4-{2-[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidin-2-yl]-1H-imidazol-5-yl}phenyl)-1-benzofuran-5-yl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate;

methyl{(1R)-2-[(2S)-2-{5-[3-methoxy-4-(5-{2-[(2S)-1-{(2R)-2-[(methoxycarbonyl)amino]-2-phenylacetyl}pyrrolidin-2-yl]-1H-imidazol-5-yl}-1-benzofuran-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-2-oxo-1-phenylethyl}carbamate;

methyl{(2S)-1-[(2S)-2-{5-[2-(2-chloro-4-{2-[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidin-2-yl]-1H-imidazol-4-yl}phenyl)-1-benzofuran-5-yl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate;

methyl{(1R)-2-[(2S)-2-{4-[3-cyano-4-(5-{2-[(2S)-1-{(2R)-2-[(methoxycarbonyl)amino]-2-phenylacetyl}pyrrolidin-2-yl]-1H-imidazol-5-yl}-1-benzofuran-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-2-oxo-1-phenylethyl}carbamate;

methyl{(2S)-1-[(2S)-2-{5-[2-(4-{2-[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidin-2-yl]-1H-imidazol-4-yl}-2-methylphenyl)-1-benzofuran-5-yl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate;

methyl[(1S)-2-[(2S)-2-(5-{3-fluoro-4-[5-(2-{(2S)-1-[(2S)-2-[(methoxycarbonyl)amino]-2-(tetrahydro-2H-pyran-4-yl)acetyl]pyrrolidin-2-yl}-1H-imidazol-5-yl) -1-benzofuran-2-yl]phenyl}-1H-imidazol-2-yl)pyrrolidin-1-yl]-2-oxo -1-(tetrahydro-2H-pyran-4-yl)ethyl]carbamate; and

methyl{(2S)-1-[(2S)-2-{4-[3-fluoro-4-(5-{2-[(2S)-1-{(2R)-2-[(methoxycarbonyl)amino]-2-phenylacetyl}pyrrolidin-2-yl]-1H-imidazol-5-yl}-1-benzofuran-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate.

12. A compound according to claim 1 , chosen from the group consisting of:

methyl{(2S)-1-[(2S)-2-{5-[4-(5-{2-[(2S)-1-{(2S)-2-[(methoxy-carbonyl)amino]-3-methylbutanoyl}pyrrolidin-2-yl]-1H-imidazol-5-yl}-1-benzofuran-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate;

methyl{(2R)-1-[(2S)-2-{5-[2-(4-{2-[(2S)-1-{(2R)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidin-2-yl]-1H-imidazol-5-yl}phenyl)-1-benzofuran-5-yl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate;

methyl{(2S)-1-[(2S)-2-{5-[4-(5-{2-[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]-4-methylpentanoyl}pyrrolidin-2-yl]-1H-imidazol-5-yl}-1-benzofuran-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-4-methyl-1-oxopentan-2-yl}carbamate;

methyl{(2S)-1-[(2S)-2-{5-[3-fluoro-4-(5-{2-[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidin-2-yl]-1H-imidazol-5-yl}-1-benzofuran-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate;

methyl{(2S)-1-[(2S)-2-{5-[3-fluoro-4-(5-{2-[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidin-2-yl]-1H-imidazol-5-yl}-1-benzofuran-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate;

methyl{(2S)-1-[(2S)-2-{5-[2-(2,6-difluoro-4-{2-[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidin-2-yl]-1H-imidazol-5-yl}phenyl)-1-benzofuran-5-yl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate;

methyl{(2S )-1-[(2S)-2-{5-[2-(2-chloro-4-{2-[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidin-2-yl]-1H-imidazol-4-yl}phenyl)-1-benzofuran-5-yl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate;

methyl{(1R)-2-[(2S)-2-{4-[3-cyano-4-(5-{2[(2S)-1-{(2R)-2-[(methoxycarbonyl)amino]-2-phenylacetyl}pyrrolidin-2-yl]-1H-imidazol-5-yl}-1-benzofuran-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-2-oxo-1-phenylethyl}carbamate; and

methyl{(2S)-1-[(2S)-2-{5-[2-(4-{2-[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidin-2-yl]-1H-imidazol-4-yl}-2-methylphenyl)-1-benzofuran-5-yl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate; and

pharmaceutically acceptable salts thereof.

13. A pharmaceutical composition comprising an effective amount of the compound according to claim 1 , and a pharmaceutically acceptable carrier.

14. The pharmaceutical composition according to claim 13 , further comprising a second therapeutic agent selected from the group consisting of HCV antiviral agents, immunomodulators, and anti-infective agents.

15. The pharmaceutical composition according to claim 13 , further comprising a second therapeutic agent selected from the group consisting of HCV protease inhibitors and HCV NSSB polymerase inhibitors.

16. A method of treating a patient infected with HCV comprising the step of administering an amount of the compound according to claim 1 effective to treat infection by HCV in a subject in need thereof.