COLLAGEN-BINDING SYNTHETIC PEPTIDOGLYCANS FOR USE IN VASCULAR INTERVENTION
This invention relates to collagen-binding synthetic peptidoglycans. More particularly, this invention relates to collagen-binding synthetic peptidoglycans for use in vascular intervention procedures. The invention also relates to kits comprising such collagen—binding synthetic peptidoglycans and catheters or stents.
1 - 46 . (canceled)
47 . A method of treating stenosis in a patient who has undergone a vascular intervention, comprising administering to a patient a peptidoglycan comprising a glycan and from 1 to 50 synthetic peptides comprising the amino acid sequence GELYKSILY (SEQ ID NO: 25).
48 . The method of claim 47 , wherein the peptide is a synthetic peptide of up to 40 amino acids.
49 . The method of claim 48 , wherein the peptide is a synthetic peptide of up to 40 amino acids comprising the amino acid sequence RRANAALKAGELYKSILY (SEQ ID NO: 17).
50 . The method of claim 47 , wherein the peptidoglycan comprises from about 1 to about 10 synthetic peptides.
51 . The method of claim 50 , wherein the glycan is heparin.
52 . The method of claim 47 , wherein the peptidoglycan comprises from about 15 to about 25 synthetic peptides.
53 . The method of claim 47 , wherein the peptidoglycan comprises from about 15 to about 20 synthetic peptides.
54 . The method of claim 47 , wherein the peptidoglycan comprises about 20 synthetic peptides.
55 . The method of claim 47 , wherein the peptidoglycan comprises about 18 synthetic peptides.
56 . The method of claim 53 , wherein the glycan is dermatan sulfate.
57 . The method of claim 47 , wherein the vascular intervention comprises grafting.
58 . The method of claim 57 , wherein the peptidoglycan is administered directly to a vessel in a patient which has been grafted.
59 . The method of claim 47 , wherein the peptidoglycan is administered to the patient in a composition comprising the peptidoglycan and one or more additional agent.
60 . The method of claim 59 , wherein each one or more additional agent is independently selected from the group consisting of a pH buffering agent, ionic strength modifying agent, viscosity modulating agent, and solubility-enhancing agent.