IP Library › Patent Application 14483175
Patent Application
App. No. 14/483,175

USE OF INTERLEUKIN-22 IN THE TREATMENT OF FATTY LIVER DISEASE

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Quick Facts
Patent No.
US None
App. No.
14/483,175
Abstract

The present invention relates to use of interleukin-22 (IL-22) for treating fatty liver disease by decreasing the levels of transaminases. The use of IL-22 in decreasing the levels of transaminases is also provided.

Claims (11)

1 . A method for treatment of fatty liver, wherein said method comprises administering to a subject in need of treatment a composition, said composition comprises a pharmaceutically effective amount of IL-22.

2 . The method according to claim 1 , wherein said composition reduces steatosis.

3 . The method according to claim 1 , wherein said composition decreases serum triglyceride level.

4 . The method according to claim 1 , wherein said composition decreases transaminase level.

5 . The method according to claim 1 , wherein said IL-22 is human IL-22.

6 . The method according to claim 1 , wherein said IL-22 is encoded by the polynucleotide of SEQ ID NO. 1.

7 . The method according to claim 1 , wherein said fatty liver disease is alcoholic fatty liver disease or non-alcoholic fatty liver disease.

8 . The method according to claim 1 , wherein said composition reduces body weight.

9 . The method according to claim 1 , wherein said composition reduces liver weight.

10 . The method according to claim 1 , wherein the pharmaceutically effective amount of IL-22 is 10 μg/kg/d-300 μg/kg/d in a mammal.

11 . The method according to claim 1 , wherein the pharmaceutically effective amount of IL-22 is 10 μg/kg/d-100 μg/kg/d in a mammal.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 29, 2014
From: HUANG, YU LIANG; HUANG, ZHI HUA; SUN, QI
To: GENERON (SHANGHAI) CORPORATION
Reel/Frame 034596/0456 →