5-substituted isoindoline compounds
This invention relates to 5-substituted isoindoline compounds, and pharmaceutically acceptable salts, solvates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.
1. A compound of formula (I):
and pharmaceutically acceptable salts, solvates, and stereoisomers thereof, wherein:
X is CH 2 or C═O;
Z is: (CH 2 ) m , wherein m is 0 or 1; or NH;
R 1 is halogen or (C 1 -C 6 )alkyl, itself optionally substituted with one or more halogen; and
R 2 is hydrogen; halogen; or (C 1 -C 6 )alkyl, itself optionally substituted with one or more halogen.
2. The compound of claim 1 , wherein X is CH 2 .
3. The compound of claim 1 , wherein X is C═O.
4. The compound of claim 1 , wherein Z is (CH 2 ) m and m is 0.
5. The compound of claim 1 , wherein Z is (CH 2 ) m and m is 1.
6. The compound of claim 1 , wherein Z is NH.
7. The compound of claim 1 , wherein R 1 is chloro, methyl, or tert-butyl.
8. The compound of claim 1 , wherein R 2 is hydrogen; chloro or trifluoromethyl.
9. The compound of claim 1 , having the structure:
or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof.
10. A pharmaceutical composition comprising a compound of claim 1 .
11. A single unit dosage form comprising a compound of claim 1 .
12. The single unit dosage form of claim 11 , which is suitable for oral or parenteral administration.