IP Library Granted Patent US 9,993,211
Granted Patent B2
US 9,993,211 · App. 14/491,872 · Granted Jun 12, 2018

System and method for automatic detection and registration of medical images

Inventors: Junichi Tokuda (Newton, MA); Sang-Eun Song (Chestnut Hill, MA); Nobuhiko Hata (Waban, MA)
Assignee: The Brigham and Women's Hospital, Inc.
A61B6/032A61B6/5211A61B34/10A61B90/37G06T3/0068G06T7/344A61B5/055A61B2090/3983A61B2576/00G06T2207/10072G06T2207/30081
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Quick Facts
Patent No.
US 9,993,211
App. No.
14/491,872
Granted
Jun 12, 2018
Kind
B2
Abstract

A system and method for automatic registration of medical images includes accessing image data of a subject and plurality of elongated fiducial markers arranged in an asymmetrical orientation and analyzing the image data to detect the elongated fiducial markers by applying a line filter to treat the elongated fiducial markers as lines within the image data. The system and method also includes matching the elongated fiducial markers within the image data to a model of the elongated fiducial markers, registering the image data with a coordinate system based on the matching, and generating a report indicating at least the registered image data.

Claims (42)

1. A system comprising:

a computer system including a non-transitive, computer-readable storage medium having stored thereon a program that causes the computer system to:

access image data illustrating a subject and plurality of elongated fiducial markers arranged in a rotationally asymmetric orientation;

analyze the image data to detect the elongated fiducial markers by applying a line filter to treat the elongated fiducial markers as lines within the image data;

enhance a contrast of the elongated fiducial markers within the image data;

match the enhanced contrast of the elongated fiducial markers within the image data to a model of the elongated fiducial markers;

register the image data with a coordinate system based on the matching of the enhanced contrast of the elongated fiducial markers to the model of the elongated fiducial markers; and

generate a report indicating at least the registered image data.

2. The system of claim 1 wherein the line filter includes a multi-scale line filter.

3. The system of claim 1 wherein the image data includes data from at least three asymmetrically oriented elongated fiducial markers.

4. The system of claim 1 wherein the image data includes three-dimensional (3D) image data.

5. The system of claim 1 wherein the computer system is further caused to iteratively determine a correspondence of the elongated fiducial markers to the model to perform the matching.

6. The system of claim 1 wherein the image data includes at least one of magnetic resonance image data and computed tomography image data.

7. The system of claim 1 wherein the report includes a plan for a therapeutic treatment of the subject.

8. A method for automatically registering medical images with an image coordinate system, the method comprising steps of:

a) positioning a fiducial frame having a plurality of elongated fiducial markers arranged rotationally asymmetric and proximate to a subject;

b) acquiring, with a medical imaging system, image data of the subject and fiducial frame;

c) applying a line filter that treats the elongated fiducial markers as lines within the image data;

d) distinguishing the elongated fiducial markers within the image data;

e) matching the elongated fiducial markers within the image data to a model of the elongated fiducial markers;

f) registering the image data with a coordinate system based on the matching of the elongated fiducial markers to the model of the elongated fiducial markers; and

g) generating a report indicating at least the registered image data.

9. The method of claim 8 further comprising registering the registered image with at least one of a surgical and a therapeutic plan using the report.

10. The method of claim 8 further comprising apply a multi-scale line filter in step c).

11. The method of claim 8 wherein step a) includes arranging at least three asymmetrically oriented elongated fiducial markers proximate to the subject.

12. The method of claim 8 wherein step b) includes acquiring three-dimensional (3D) image data.

13. The method of claim 8 wherein step e) includes iteratively determining a correspondence of the elongated fiducial markers to the model.

14. The method of claim 8 wherein the medical imaging system includes at least one of magnetic resonance system and a computed tomography system.

15. The method of claim 8 wherein steps c) through g) are performed automatically by a computer system that includes a non-transitive, computer-readable storage medium having stored thereon a program that causes the computer system to carry out steps c) through g) automatically.

16. The method of claim 8 wherein the fiducial frame is a free-standing system and the elongated fiducial markers are arranged to form opposing z-shapes connected by an elongated fiducial marker.

17. A system for automatically registering medical images with an image coordinate system, the system comprising:

a fiducial frame having a plurality of elongated fiducial markers arranged rotationally asymmetric within the fiducial frame;

an imaging system configured to acquire image data from the fiducial frame and a subject located proximate to the fiducial frame;

a computer system including a non-transitive, computer-readable storage medium having stored thereon a program that causes the computer system to:

access the image data of the subject and the fiducial frame;

analyze the image data to detect the elongated fiducial markers by applying a line filter to treat the elongated fiducial markers as lines within the image data;

match the elongated fiducial markers detected within the image data to a model of the elongated fiducial markers;

register the image data with a coordinate system based on the matching of the enhanced contrast of the elongated fiducial markers to the model of the elongated fiducial markers; and

generate a report indicating at least the registered image data.

18. The system of claim 17 wherein the line filter includes a multi-scale line filter.

19. The system of claim 17 wherein the medical imaging data includes three-dimensional (3D) image data.

20. The system of claim 17 wherein the computer system is further caused to iteratively determine a correspondence of the elongated fiducial markers to the model to perform the match.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 15, 2018
From: TOKUDA, JUNICHI; SONG, SANG-EUN; HATA, NOBUHIKO
To: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
Reel/Frame 045808/0372 →
CONFIRMATORY LICENSE Recorded Aug 31, 2015
From: BRIGHAM AND WOMEN'S HOSPITAL
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 036509/0666 →
Continuity (2)
Provisional Application 61880520 · Sep 20, 2013
Related Publication 20150087965A1 · Mar 26, 2015