IP Library › Granted Patent US 9,376,465
Granted Patent B2
US 9,376,465 · App. 14/492,753 · Granted Jun 28, 2016

Cyclin based inhibitors of CDK2 and CDK4

Inventors: Campbell McInnes (Irmo, SC); Shu Liu (West Columbia, SC)
Assignee: UNIVERSITY OF SOUTH CAROLINA
C07K5/1024A61K38/07C07K5/0202C07K5/06095C07K5/06139C07K5/0821C07K5/101C07K5/1016C07K5/1019C07K14/4738
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Quick Facts
Patent No.
US 9,376,465
App. No.
14/492,753
Granted
Jun 28, 2016
Kind
B2
Abstract

Structural and functional analysis of peptide inhibitor binding to the cyclin D and cyclin A groove has been investigated and used to design peptides that provide the basis for structure-activity relationships, have improved binding and have potential for development as chemical biology probes, as potential diagnostics and as therapeutics in the treatment of proliferative diseases including cancer and inflammation.

Claims (2)

1. A synthetic CDK/cyclin inhibitor that inhibits interaction of a complex formed between a first CDK protein and a first cyclin protein with a substrate of the complex, the synthetic CDK/cyclin inhibitor having the following structure:

wherein R1 is methyl and R2 has the following structure:

Assignments (2)
CONFIRMATORY LICENSE Recorded Feb 7, 2017
From: UNIVERSITY OF SOUTH CAROLINA
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 041647/0767 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 22, 2014
From: MCINNES, CAMPBELL; LIU, SHU
To: UNVERSITY OF SOUTH CAROLINA
Reel/Frame 033789/0298 →
Continuity (4)
Division 13940407 · Jul 12, 2013
Continuation In Part 13851661 · Mar 27, 2013
Provisional Application 61616154 · Mar 27, 2012
Related Publication 20150011730A1 · Jan 8, 2015