COLLAGEN-BINDING SYNTHETIC PEPTIDOGLYCANS FOR WOUND HEALING
Methods and compositions for promoting wound healing in a patient by administering a collagen-binding synthetic peptidoglycan to the patient are described. Additionally, methods and compositions are described for decreasing scar formation in a patient by administering a collagen-binding synthetic peptidoglycan to the patient.
1 - 54 . (canceled)
55 . A method of accelerating wound healing in a patient in need thereof, comprising administering to the patient a peptidoglycan comprising a glycan, and from 1 to 30 collagen-binding peptides having from 5 to 40 amino acids.
56 . The method of claim 55 , wherein the peptides comprise an amino acid sequence having 80% sequence identity to RRANAALKAGELYKSILYGC (SEQ ID NO: 1) and the amino acid sequence GELYKSILY (SEQ ID NO: 18).
57 . The method of claim 55 , wherein the glycan is selected from the group consisting of alginate, agarose, dextran, chondroitin, dermatan, dermatan sulfate, heparan, heparin, keratin and hyaluronan.
58 . The method of claim 55 , wherein the glycan is dermatan sulfate.
59 . The method of claim 55 , wherein the glycan is heparin.
60 . The method of claim 59 , wherein the peptidoglycan comprises about five collagen-binding peptides.
61 . The method of claim 55 , wherein the peptides are RRANAALKAGELYKSILYGS (SEQ ID NO: 19).
62 . The method of claim 55 , wherein the peptides are RRANAALKAGELYKSILYGC (SEQ ID NO: 1), and the glycine-cysteine is optional.
63 . The method of claim 55 , wherein the peptides are a synthetic peptide having 90% sequence identity to RRANAALKAGELYKSILYGC (SEQ ID NO: 1) and the amino acid sequence GELYKSILY (SEQ ID NO: 18).
64 . The method of claim 55 , wherein the peptides are a synthetic peptide having 95% sequence identity to RRANAALKAGELYKSILYGC (SEQ ID NO: 1) and the amino acid sequence GELYKSILY (SEQ ID NO: 18).
65 . The method of claim 55 , wherein the peptidoglycan is administered in a composition further comprising a pharmaceutically acceptable excipient or diluent, or a combination thereof.
66 . The method of claim 65 , wherein the composition is formulated for topical administration.
67 . A method of healing a wound to achieve enhanced wound strength in a patient in need thereof, comprising administering to the patient a peptidoglycan comprising a glycan, and from 1 to 30 collagen-binding peptides having from 5 to 40 amino acids.
68 . The method of claim 67 , wherein the peptides comprise an amino acid sequence having 80% sequence identity to RRANAALKAGELYKSILYGC (SEQ ID NO: 1) and the amino acid sequence GELYKSILY (SEQ ID NO: 18).
69 . The method of claim 67 , wherein the glycan is selected from the group consisting of alginate, agarose, dextran, chondroitin, dermatan, dermatan sulfate, heparan, heparin, keratin and hyaluronan.
70 . The method of claim 67 , wherein the glycan is dermatan sulfate.
71 . The method of claim 67 , wherein the glycan is heparin.
72 . The method of claim 71 , wherein the peptidoglycan comprises about five collagen-binding peptides.
73 . The method of claim 67 , wherein the peptide is RRANAALKAGELYKSILYGS (SEQ ID NO: 19).
74 . The method of claim 67 , wherein the peptide is RRANAALKAGELYKSILYGC (SEQ ID NO: 1), and the glycine-cysteine is optional.
75 . The method of claim 67 , wherein the peptide is a synthetic peptide having 90% sequence identity to RRANAALKAGELYKSILYGC (SEQ ID NO: 1) and the amino acid sequence GELYKSILY (SEQ ID NO: 18).
76 . The method of claim 67 , wherein the peptide is a synthetic peptide having 95% sequence identity to RRANAALKAGELYKSILYGC (SEQ ID NO: 1) and the amino acid sequence GELYKSILY (SEQ ID NO: 18).
77 . The method of claim 67 , wherein the peptidoglycan is administered in a composition further comprising a pharmaceutically acceptable excipient or diluent, or a combination thereof.
78 . The method of claim 77 , wherein the composition is formulated for topical administration.