IP Library › Granted Patent US 9,897,595
Granted Patent B2
US 9,897,595 · App. 14/503,914 · Granted Feb 20, 2018

Compositions and methods for the detection of zinc

Inventors: Emily L. Que (Chicago, IL); Thomas V. O'Halloran (Chicago, IL); Teresa K. Woodruff (Chicago, IL)
Assignee: Northwestern University
G01N33/52A61K31/40A61K31/435A61K31/69C07F5/022G01N31/22G01N33/5091G01N33/84
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 9,897,595
App. No.
14/503,914
Granted
Feb 20, 2018
Kind
B2
Abstract

The invention relates generally to compositions and methods for the detection of zinc. In particular, compositions and methods are provided to detect changes in cellular zinc concentration and to correlate them to cellular phenomena.

Claims (7)

1. A Zn-responsive probe which has the following chemical structure:

wherein each of said R 3 s are individually selected from: H, CH 3 , an alkyl group, an O-alkyl group, and an N-alkyl group;

wherein said R 1 is selected from: H, CH 3 , and an alkyl group; and

wherein said R 2 is a Zn binding group which has the following structure:

2. The Zn-responsive probe of claim 1 , wherein said chemical structure is as follows:

3. The Zn-responsive probe of claim 1 , wherein each of said R 3 s are CH 3 .

4. The Zn-responsive probe of claim 1 , wherein said R 1 is CH 3 .

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 2, 2014
From: QUE, EMILY L.; O'HALLORAN, THOMAS V.; WOODRUFF, TERESA K.
To: NORTHWESTERN UNIVERSITY
Reel/Frame 033874/0031 →
Continuity (4)
Continuation 14078743 · Nov 13, 2013
Continuation In Part 13442453 · Apr 9, 2012
Provisional Application 61726845 · Nov 15, 2012
Related Publication 20150080575A1 · Mar 19, 2015